Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 33-37

  Kim, Heeyeon ^a   Choi, Hyun Kyu ^b   Jeong, Tae Cheon ^b   Jahng, Yurngdong ^b   Kim, Dong Hyun ^c   Lee, Seung Ho ^b   Lee, Sangkyu ^a  

^a Kyungpook National University   (South Korea)

^b Yeungnam University   (South Korea)

^c Inje University College of Medicine   (South Korea)

Author keywords

Cytochrome P450; Herb drug interaction; Inhibition; Mollugin

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; MOLLUGIN; PHENACETIN; PHENACETIN O DEETHYLASE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEETHYLATION; DRUG STRUCTURE; ENZYME ACTIVITY; HERB DRUG INTERACTION; HUMAN; IC 50; LIVER MICROSOME; RUBIA CORDIFOLIA;

CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; HERB-DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; PYRANS; RECOMBINANT PROTEINS;

RUBIA CORDIFOLIA;

EID: 84867116544     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.09.013     Document Type: Article

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