Influence of poly(L-lactic acid) nanofibers and BMP-2-containing poly(L-lactic acid) nanofibers on growth and osteogenic differentiation of human mesenchymal stem cells

TheScientificWorldJournal

Volumn 8, Issue , 2008, Pages 1269-1279

  Schofer, Markus D ^a   Fuchs Winkelmann, Susanne ^a   Gräbedünkel, Christian ^a   Wack, Christina ^a   Dersch, Roland ^b   Rudisile, Markus ^b   Wendorff, Joachim H ^b   Greiner, Andreas ^b   Paletta, Jürgen R J ^a   Boudriot, Ulrich ^c  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c Sankt Elisabeth Hospital   (Germany)

Author keywords

BMP; Human mesenchymal stem cells; Nanofibers; PLLA; Tissue engineering

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; DEXAMETHASONE; GROWTH FACTOR; NANOFIBER; OSTEOCALCIN; POLYLACTIC ACID;

ARTICLE; BONE DEVELOPMENT; CELL DENSITY; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HUMANS; LACTIC ACID; MESENCHYMAL STEM CELLS; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; OSTEOCALCIN; OSTEOGENESIS; POLYMERS; STEM CELLS; TISSUE ENGINEERING;

EID: 58449111216     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2008.163     Document Type: Article

References (46)

1. Kneser, U., Schaefer, D.J., Polykandriotis, E., and Horch, R.E. (2006) Tissue engineering of bone: the reconstructive surgeon's point of view. J. Cell. Mol. Med. 10, 7-19.
2. Arrington, E.D., Smith, W.J., Chambers, H.G., Bucknell, A.L., and Davino, N.A. (1996) Complications of iliac crest bone graft harvesting. Clin. Orthop. Relat. Res. (329), 300-309.
3. Khan, Y., Yaszemski, M.J., Mikos, A.G., and Laurencin, C.T. (2008) Tissue engineering of bone: material and matrix considerations. J. Bone Joint Surg. Am. 90(Suppl 1), 36-42.
4. Meijer, G.J., de Bruijn, J.D., Koole, R., and van Blitterswijk, C.A. (2007) Cell-based bone tissue engineering. PLoS Med. 4, e9.
5. Damien, C.J. and Parsons, J.R. (1991) Bone graft and bone graft substitutes: a review of current technology and applications. J. Appl. Biomater. 2, 187-208.
6. Lane, J.M., Tomin, E., and Bostrom, M.P. (1999) Biosynthetic bone grafting. Clin. Orthop. Relat. Res. (367 Suppl), S107-117.
7. Ashammakhi, N., Ndreu, A., Yang, Y., Ylikauppila, H., and Nikkola, L. (2008) Nanofiber-based scaffolds for tissue engineering. Eur. J. Plast. Surg., online first.
8. Zhang, Y., Lim, C.T., Ramakrishna, S., and Huang, Z.M. (2005) Recent development of polymer nanofibers for biomedical and biotechnological applications. J. Mater. Sci. Mater. Med. 16, 933-946.
9. Li, W.J., Laurencin, C.T., Caterson, E.J., Tuan, R.S., and Ko, F.K. (2002) Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J. Biomed. Mater. Res. 60, 613-621.
10. Liao, S., Li, B., Ma, Z., Wei, H., Chan, C., and Ramakrishna, S. (2006) Biomimetic electrospun nanofibers for tissue regeneration. J. Biomed. Mater. 1, R45-53.
11. Greiner, A. and Wendorff, J.H. (2007) Electrospinning: a fascinating method for the preparation of ultrathin fibres. Angew. Chem. Int. Ed. 46, 5670-5703.
12. Jäger, M., Fischer, J., Dohrn, W., Li, X., Ayers, D.C., Czibere, A., Prall, W.C., Lensing-Höhn, S., and Krauspe, R. (2008) Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J. Orthop. Res. 26(11), 1440-1448.
13. Schmidmaier, G., Wildemann, B., Cromme, F., Kandziora, F., Haas, N.P., and Raschke, M. (2002) Bone morphogenetic protein-2 coating of titanium implants increases biomechanical strength and accelerates bone remodeling in fracture treatment: a biomechanical and histological study in rats. Bone 30, 816-822.
14. Schmidmaier, G., Lucke, M., Schwabe, P., Raschke, M., Haas, N.P., and Wildemann, B. (2006) Collective review: bioactive implants coated with poly(D,L-lactide) and growth factors IGF-I, TGF-beta1, or BMP-2 for stimulation of fracture healing. J. Long Term Eff. Med. Implants 16, 61-69.
15. Raschke, M., Wildemann, B., Inden, P., Bail, H., Flyvbjerg, A., Hoffmann, J., Haas, N.P., and Schmidmaier, G. (2002) Insulin-like growth factor-1 and transforming growth factor-beta1 accelerates osteotomy healing using polylactide-coated implants as a delivery system: a biomechanical and histological study in minipigs. Bone 30, 144-151.
16. Schmidmaier, G., Wildemann, B., Lubberstedt, M., Haas, N.P., and Raschke, M. (2003) IGF-I and TGF-beta 1 incorporated in a poly(D,L-lactide) implant coating stimulates osteoblast differentiation and collagen-1 production but reduces osteoblast proliferation in cell culture. J. Biomed. Mater. Res. B Appl. Biomater. 65, 157-162.
17. Boudriot, U., Dersch, R., Goetz, B., Griss, P., Greiner, A., and Wendorff, J.H. (2004) Elektrogesponnene Poly-L-Laktid-Nanofasern als resorbierbare Matrix fur Tissue-Engineering. Biomed. Tech. (Berl.) 49, 242-247.
18. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147.
19. Brendel, C., Kuklick, L., Hartmann, O., Kim, T.D., Boudriot, U., Schwell, D., and Neubauer, A. (2005) Distinct gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes. Gene Expr. 12, 245-257.
20. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., and Bruder, S.P. (1997) Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64, 295-312.
21. Fuchs, T.F., Petersen, W., Vordemvenne, T., Stange, R., Raschke, M., and Paletta, J.R. (2007) Influence of synovial fluid on human osteoblasts: an in vitro study. TheScientificWorldJOURNAL 7, 2012-2020.
22. Frank, O., Heim, M., Jakob, M., Barbero, A., Schafer, D., Bendik, I., Dick, W., Heberer, M., and Martin, I. (2002) Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. J. Cell. Biochem. 85, 737-746.
23. Martin, I., Jakob, M., Schafer, D., Dick, W., Spagnoli, G., and Heberer, M. (2001) Quantitative analysis of gene expression in human articular cartilage from normal and osteoarthritic joints. Osteoarthritis Cartilage 9, 112-118.
24. Waris, E., Ashammakhi, N., Kaarela, O., Raatikainen, T., and Vasenius, J. (2004) Use of bioabsorbable osteofixation devices in the hand. J. Hand Surg. [Br.] 29, 590-598.
25. Suuronen, R., Kallela, I., and Lindqvist, C. (2000) Bioabsorbable plates and screws: current state of the art in facial fracture repair. J. Craniomaxillofac. Trauma 6, 19-27; discussion 28-30.
26. Tanaka, N., Hirose, K., Sakahashi, H., Ishima, T., and Ishii, S. (2004) Usefulness of bioabsorbable thread pins after resection arthroplasty for rheumatoid forefoot reconstruction. Foot Ankle Int. 25, 496-502.
27. Giavaresi, G., Tschon, M., Borsari, V., Daly, J.H., Liggat, J.J., Fini, M., Bonazzi, V., Nicolini, A., Carpi, A., Morra, M., Cassinelli, C., and Giardino, R. (2004) New polymers for drug delivery systems in orthopaedics: in vivo biocompatibility evaluation. Biomed. Pharmacother. 58, 411-417.
28. Dersch, R., Liu, T., Schaper, A.K., Greiner, A., and Wendorff, J.H. (2003) Electrospun nanofibers: internal structure and intrinsic orientation. J Polymer Sci. A Polymer Chem. 41, 545-553.
29. Zeng, J., Hou, H., Schaper, A., Wendorff, J.H., and Greiner, A. (2003) Poly-L-lactide nanofibers by electrospinning - influence of solution viscosity and electrical conductivity on fiber diameter and fiber morphology. e-polymers, No 9.
30. Boudriot, U., Dersch, R., Greiner, A., and Wendorff, J.H. (2006) Electrospinning approaches toward scaffold engineering - a brief overview. Artif. Organs 30, 785-792.
31. Boudriot, U., Goetz, B., Dersch, R., Greiner, A., and Wendorff, H.J. (2005) Role of Electrospun Nanofibers in Stem Cell Technologies and Tissue Engineering. Macromolecular Symposia 225. pp. 9-16.
32. Jahno, V.D., Ribeiro, G.B., dos Santos, L.A., Ligabue, R., Einloft, S., Ferreira, M.R., and Bombonato-Prado, K.F. (2007) Chemical synthesis and in vitro biocompatibility tests of poly (L-lactic acid). J. Biomed. Mater. Res. A 83, 209-215.
33. Ishaug, S.L., Yaszemski, M.J., Bizios, R., and Mikos, A.G. (1994) Osteoblast function on synthetic biodegradable polymers. J. Biomed. Mater. Res. 28, 1445-1453.
34. Hu, J., Liu, X., and Ma, P.X. (2008) Induction of osteoblast differentiation phenotype on poly(l-lactic acid) nanofibrous matrix. Biomaterials 29, 3815-3821.
35. Ngiam, M., Liao, S., Patil, A.J., Cheng, Z., Yang, F., Gubler, M.J., Ramakrishna, S., and K., C.C. (2008) Fabrication of mineralized polymeric nanofibrous composites for bone graft materials. Tissue Eng. Part A [Epub ahead of print].
36. Venugopal, J.R., Low, S., Choon, A.T., Kumar, A.B., and Ramakrishna, S. (2008) Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration. Artif. Organs 32, 388-397.
37. Shih, Y.R., Chen, C.N., Tsai, S.W., Wang, Y.J., and Lee, O.K. (2006) Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. Stem Cells 24, 2391-2397.
38. Li, W.J., Cooper, J.A., Jr., Mauck, R.L., and Tuan, R.S. (2006) Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater. 2, 377-385.
39. Maretschek, S., Greiner, A., and Kissel, T. (2008) Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. J. Control. Release 127, 180-187.
40. Kim, K., Luu, Y.K., Chang, C., Fang, D., Hsiao, B.S., Chu, B., and Hadjiargyrou, M. (2004) Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J. Control. Release 98, 47-56.
41. Li, D., Frey, M.W., and Baeumner, A.J. (2006) Electrospun polylactic acid nanofiber membranes as substrates for biosensor assemblies. J. Membr. Sci. 279, 354-363.
42. Nie, H., Soh, B.W., Fu, Y.C., and Wang, C.H. (2008) Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery. Biotechnol. Bioeng. 99, 223-234.
43. Fu, Y.C., Nie, H., Ho, M.L., Wang, C.K., and Wang, C.H. (2008) Optimized bone regeneration based on sustained release from three-dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol. Bioeng. 99, 996-1006.
44. Patel, S., Kurpinski, K., Quigley, R., Gao, H., Hsiao, B.S., Poo, M.M., and Li, S. (2007) Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett. 7, 2122-2128.
45. Nur, E.K.A., Ahmed, I., Kamal, J., Babu, A.N., Schindler, M., and Meiners, S. (2008) Covalently attached FGF-2 to three-dimensional polyamide nanofibrillar surfaces demonstrates enhanced biological stability and activity. Mol. Cell. Biochem. 309, 157-166.
46. Hosseinkhani, H., Hosseinkhani, M., Khademhosseini, A., and Kobayashi, H. (2007) Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. J. Control. Release 117, 380-386.