Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: A possible mechanism for collagen-dependent osteoblastic differentiation

Journal of Bone and Mineral Research

Volumn 17, Issue 2, 2002, Pages 240-248

  Suzawa, Miyuki ^a   Tamura, Yasuhiro ^b   Fukumoto, Seiji ^b   Miyazono, Kohei ^b   Fujita, Toshiro ^b   Kato, Shigeaki ^a   Takeuchi, Yasuhiro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Extracellular signal regulated kinase; Integrin; Osteoblast; Ras; Smad1

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; COLLAGEN TYPE 1; FOCAL ADHESION KINASE; INTEGRIN; SMAD PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036155344     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.2.240     Document Type: Article

References (40)

1. The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2
2. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro
3. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
4. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts
5. TGF-β signalling from cell membrane to nucleus through SMAD proteins
6. Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins
7. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
8. Differentiation and transforming growth factor-β receptor down-regulation by collagen-α2β1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells
9. Role of the α2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor
10. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2
11. Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro
12. Integrins and signal transduction pathways: The road taken
13. Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development
14. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
15. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
16. Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
17. FGF-4 and BMP-2 have opposite effects on limb growth
18. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
19. Antagonistic interactions between FGF and BMP signaling pathways: A mechanism for positioning the sites of tooth formation
20. 3 of in vitro mineralization induced by osteoblast-like MC3T3-E1 cells
21. A human Mad protein acting as a BMP-regulated transcriptional activator
22. Transcription activation by the adenovirus Ela protein
23. ras in Xenopus mesoderm induction
24. Smad6 inhibits signalling by the TGF-β superfamily
25. Involvement of the MAP kinase cascade in Xenopus mesoderm induction
26. Differentiation and cell surface expression of transforming growth factor-β receptors are regulated by interaction with matrix collagen in murine osteoblastic cells
27. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
28. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration
29. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line
30. Smad1 and Smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
31. Activation of Ras by receptor tyrosine kinases
32. Transcriptional activation of c-fos and c-jun protooncogenes by serum growth factors in osteoblast-like MC3T3-E1 cells
33. Down-regulation of osteoblastic cell differentiation by epidermal growth factor receptor
34. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
35. Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
36. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
37. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
38. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
39. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
40. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation