Focal adhesion kinase activity is required for bone morphogenetic protein - Smad1 signaling and osteoblastic differentiation in murine MC3T3-E1 cells

Journal of Bone and Mineral Research

Volumn 16, Issue 10, 2001, Pages 1772-1779

  Tamura, Y ^a   Takeuchi, Y ^a   Suzawa, M ^a   Fukumoto, S ^a   Kato, M ^a   Miyazono, K ^a   Fujita, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bone morphogenetic protein; Focal adhesion kinase; Integrin; Osteoblast; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CELL MARKER; FOCAL ADHESION KINASE; OSTEOCALCIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; OSTEOBLAST; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HUMANS; MICE; MICROFILAMENTS; OSTEOBLASTS; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034803052     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.10.1772     Document Type: Article

References (24)

1. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype
2. Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells
3. Differentiation and cell surface expression of transforming growth factor-β receptors are regulated by interaction with matrix collagen in murine osteoblastic cells
4. Differentiation and transforming growth factor-β receptor down-regulation by collagen-α2β1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells
5. Role of the α2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factor
6. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2
7. Integrins and signal transduction pathways: The road taken
8. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
9. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not cytoskeletal organization
10. Focal adhesion kinase overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-src
11. Novel regulators of bone formation: Molecular clones and activities
12. Recombinant human bone morphogenetic protein induces bone formation
13. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
14. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
15. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
16. Regulation of Smad activity
17. Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro
18. MADR1, a MAD-related protein that functions in BMP2 signaling pathways
19. Smad6 is a Smad1/5-induced Smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
20. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
21. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1
22. Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells
23. Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
24. Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK