Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus

Biopharmaceutics and Drug Disposition

Volumn 33, Issue 7, 2012, Pages 378-402

  Mudie, Deanna M ^a   Shi, Yi ^b   Ping, Haili ^a,c   Gao, Ping ^b   Amidon, Gordon L ^a   Amidon, Gregory E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ABBOTT LABORATORIES   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

biphasic; dissolution; oral absorption; physiological; two phase

Indexed keywords

IBUPROFEN; NIMESULIDE; PIROXICAM;

AQUEOUS SOLUTION; ARTICLE; DRUG ABSORPTION; DRUG DIFFUSION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG TRANSPORT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; STEADY STATE;

ABSORPTION; BIOPHARMACEUTICS; DRUG DISCOVERY; DRUGS, INVESTIGATIONAL; HUMANS; IBUPROFEN; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PIROXICAM; SOLUBILITY; SOLUTIONS; SULFONAMIDES;

EID: 84867097269     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1803     Document Type: Article

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