Next-generation antithrombotics in ischemic stroke: Preclinical perspective on bleeding-free antithrombosis

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 10, 2012, Pages 1831-1840

  Kraft, Peter ^a   De Meyer, Simon F ^b   Kleinschnitz, Christoph ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

coagulation; FXII; glycoprotein Ib; platelets; Stim; von Willebrand factor

Indexed keywords

ABCIXIMAB; ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 12A; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; COLLAGEN; GLYCOPROTEIN IB ALPHA; GLYCOPROTEIN VI; PHOSPHODIESTERASE INHIBITOR; RHA INFESTIN 4; SERINE PROTEINASE INHIBITOR; STROMAL INTERACTION MOLECULE 1; THROMBIN INHIBITOR; THROMBOXANE RECEPTOR BLOCKING AGENT; TIROFIBAN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ANTICOAGULANT THERAPY; BLEEDING; BLOOD CLOTTING; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CALCIUM HOMEOSTASIS; CEREBROVASCULAR DISEASE; DRUG EFFICACY; DRUG SAFETY; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; RISK; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOEMBOLISM; TRANSGENIC MOUSE; TRIATOMA INFESTANS;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION FACTORS; BLOOD PLATELETS; BRAIN; BRAIN ISCHEMIA; FACTOR XII; HEMORRHAGE; HEMOSTASIS; HUMANS; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; STROKE; THROMBOSIS;

EID: 84867088188     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.108     Document Type: Review

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