Sustained reperfusion after blockade of glycoprotein-receptor-IB in focal cerebral ischemia: An MRI study at 17.6 Tesla

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Pham, Mirko ^a   Helluy, Xavier ^b   Kleinschnitz, Christoph ^b   Kraft, Peter ^b   Bartsch, Andreas J ^a   Jakob, Peter ^b   Nieswandt, Bernhard ^c   Bendszus, Martin ^a   Stoll, Guido ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; GLYCOPROTEIN IB BLOCKING ANTIBODY FAB FRAGMENT; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; THROMBIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; DISEASE COURSE; DRUG MECHANISM; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; REPERFUSION; SPIN LABELING; SUBCORTEX; THROMBOCYTE ADHESION; ANIMAL; BRAIN CIRCULATION; CEREBRAL ARTERY DISEASE; DRUG EFFECT; IMMUNOLOGY; PATHOPHYSIOLOGY; TIME; VASCULARIZATION;

ANIMALIA; MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DISEASE PROGRESSION; IMMUNOGLOBULIN FAB FRAGMENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; MICE; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; TIME FACTORS;

EID: 79953666002     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018386     Document Type: Article

References (34)

1. Murray CJ, Lopez AD, (1997) Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349: 1269-1276.
2. Dirnagl U, Iadecola C, Moskowitz MA, (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22: 391-397.
3. Stoll G, Kleinschnitz C, Nieswandt B, (2008) Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood 112: 3555-3562.
4. Coutts SB, Goyal M, (2009) When recanalization does not improve clinical outcomes. Stroke 40: 2661.
5. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, et al. (2008) Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 7: 299-309.
6. Kleinschnitz C, De Meyer SF, Schwarz T, Austinat M, Vanhoorelbeke K, et al. (2009) Deficiency of von Willebrand factor protects mice from ischemic stroke. Blood 113: 3600-3603.
7. Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, et al. (2007) Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation 115: 2323-2330.
8. Varga-Szabo D, Pleines I, Nieswandt B, (2008) Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 28: 403-412.
9. Petri B, Broermann A, Li H, Khandoga AG, Zarbock A, et al. (2010) Von Willebrand factor promotes leukocyte extravasation. Blood Epub Ahead of print.
10. Stoll G, Kleinschnitz C, Nieswandt B, (2010) Combating innate inflammation: a new paradigm for acute treatment of stroke. Ann NY Acad Sci 1207: 149-154.
11. Dirnagl U, (2006) Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab 26: 1465-1478.
12. Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, et al. (2003) A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 197: 41-49.
13. Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, et al. (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203: 513-518.
14. Varga-Szabo D, Braun A, Kleinschnitz C, Bender M, Pleines I, et al. (2008) The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. J Exp Med 205: 1583-1591.
15. Pham M, Kleinschnitz C, Helluy X, Bartsch AJ, Austinat M, et al. (2010) Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI. Neuroimage 49: 2907-2914.
16. Williams DS, Detre JA, Leigh JS, Koretsky AP, (1992) Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Natl Acad Sci U S A 89: 212-216.
17. Wong EC, Buxton RB, Frank LR, (1998) A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging. Magn Reson Med 40: 348-355.
18. Detre JA, Leigh JS, Williams DS, Koretsky AP, (1992) Perfusion imaging. Magn Reson Med 23: 37-45.
19. Maccotta L, Detre JA, Alsop DC, (1997) The efficiency of adiabatic inversion for perfusion imaging by arterial spin labeling. NMR Biomed 10: 216-221.
20. Zhang W, Williams DS, Koretsky AP, (1993) Measurement of rat brain perfusion by NMR using spin labeling of arterial water: in vivo determination of the degree of spin labeling. Magn Reson Med 29: 416-421.
21. Leithner C, Muller S, Fuchtemeier M, Lindauer U, Dirnagl U, et al. (2010) Determination of the brain-blood partition coefficient for water in mice using MRI. J Cereb Blood Flow Metab 30: 1821-1824.
22. Setjskal EO, Tanner JE, (1965) Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42: 288-292.
23. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, et al. (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23 (Suppl 1): S208-219.
24. Jenkinson M, Bannister P, Brady M, Smith S, (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17: 825-841.
25. MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, et al. (2004) A multimodal, multidimensional atlas of the C57BL/6J mouse brain. J Anat 204: 93-102.
26. Nichols TE, Holmes AP, (2002) Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 15: 1-25.
27. De Meyer SF, Schwarz T, Deckmyn H, Denis CV, Nieswandt B, et al. (2010) Binding of von Willebrand Factor to Collagen and Glycoprotein Ib{alpha}, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol.
28. Denes A, Thornton P, Rothwell NJ, Allan SM, (2010) Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav Immun 24: 708-723.
29. Stoll G, Jander S, Schroeter M, (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56: 149-171.
30. Stoll G, Kleinschnitz C, Nieswandt B, (In press.) Combating innate inflammation: a new paradigm for acute treatment of stroke? In: Del Zoppo GJ, Gorrelick P, editors. Innate inflammation as the common pathway of risk factors leading to transient ischemic attacks and stroke: pathophysiology and potential interventions: Ann NY Acad Sci.
31. Barber PA, Hoyte L, Kirk D, Foniok T, Buchan A, et al. (2005) Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T. Neurosci Lett 388: 54-59.
32. Kaur J, Tuor UI, Zhao Z, Petersen J, Jin AY, et al. (2009) Quantified T1 as an adjunct to apparent diffusion coefficient for early infarct detection: a high-field magnetic resonance study in a rat stroke model. Int J Stroke 4: 159-168.
33. De Meyer SF, Schwarz T, Deckmyn H, Denis CV, Nieswandt B, et al. (2010) Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice-brief report. Arterioscler Thromb Vasc Biol 30: 1949-1951.
34. Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, et al. (2010) Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal 3: ra1.