Evidence for radical-mediated catalysis by HppE: A study using cyclopropyl and methylenecyclopropyl substrate analogues

Journal of the American Chemical Society

Volumn 134, Issue 39, 2012, Pages 16171-16174

  Huang, Hui ^a   Chang, Wei Chen ^a   Pai, Pei Jing ^b   Romo, Anthony ^a   Mansoorabadi, Steven O ^a   Russell, David H ^b   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC FOSFOMYCIN; CYCLOPROPYL; ENZYMATIC ASSAY; ENZYME INACTIVATION; EXPERIMENTAL EVIDENCE; RADICAL CLOCKS; RING OPENING; ULTRA-FAST;

ANTIBIOTICS; BIOCHEMISTRY; ENZYMES; KETONES; PROBES; REACTION INTERMEDIATES;

CATALYSIS;

(R) 2 HYDROXYPROPYLPHOSPHONIC ACID; (S) 2 HYDROXYPROPYLPHOSPHONIC ACID; CYCLOPROPANE DERIVATIVE; CYCLOPROPYL; EPOXIDE; FOSFOMYCIN; METHYLENECYCLOPROPYL DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RADICAL; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME INACTIVATION; EPOXIDATION; OXIDATION;

BIOCATALYSIS; CYCLOPROPANES; ENZYME ACTIVATION; FREE RADICALS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PHOSPHOROUS ACIDS;

EID: 84867065791     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3078126     Document Type: Article

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