Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme

Nature

Volumn 437, Issue 7060, 2005, Pages 838-844

  Higgins, Luke J ^a   Yan, Feng ^b   Liu, Pinghua ^a,b   Liu, Hung Wen ^b   Drennan, Catherine L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; ENZYMES; REACTION KINETICS; X RAYS;

CONFORMATIONAL CHANGES; DIOXYGEN BINDING; EPOXIDATION; SUBSTRATE BINDING;

BIOSYNTHESIS;

2 OXOGLUTARIC ACID; APOENZYME; COBALT; FOSFOMYCIN; HYDROXYPROPYLPHOSPHONIC ACID EPOXIDASE; IRON; OXYGEN; PHOSPHONIC ACID DERIVATIVE; RADICAL; TROMETAMOL; UNCLASSIFIED DRUG;

ANTIBIOTICS; ENZYME;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CATALYSIS; CATALYST; CONFORMATION; DRUG STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; PRIORITY JOURNAL; X RAY;

EID: 27144467824     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03924     Document Type: Article

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