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Volumn 43, Issue 3, 2012, Pages 1339-1348

Metabolism and neurotoxicity of homocysteine thiolactone in mice: Protective role of bleomycin hydrolase

Author keywords

Alzheimer's disease; Bleomycin hydrolase; Brain; Homocysteine thiolactone; Seizures

Indexed keywords

BLEOMYCIN HYDROLASE; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE;

EID: 84867064569     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1207-5     Document Type: Article
Times cited : (39)

References (52)
  • 1
    • 0030008565 scopus 로고    scopus 로고
    • Human bleomycin hydrolase: Molecular cloning, sequencing, functional expression, and enzymatic characterization
    • DOI 10.1021/bi960092y
    • Bromme D, Rossi AB, Smeekens SP, Anderson DC, Payan DG (1996) Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry 35:6706-6714 (Pubitemid 26172429)
    • (1996) Biochemistry , vol.35 , Issue.21 , pp. 6706-6714
    • Bromme, D.1    Rossi, A.B.2    Smeekens, S.P.3    Anderson, D.C.4    Payan, D.G.5
  • 2
    • 13244287981 scopus 로고    scopus 로고
    • The determination of homocysteine-thiolactone in human plasma
    • DOI 10.1016/j.ab.2004.11.035, PII S000326970400939X
    • Chwatko G, Jakubowski H (2005a) The determination of homocysteine- thiolactone in human plasma. Anal Biochem 337:271-277 (Pubitemid 40187254)
    • (2005) Analytical Biochemistry , vol.337 , Issue.2 , pp. 271-277
    • Chwatko, G.1    Jakubowski, H.2
  • 3
    • 12944309749 scopus 로고    scopus 로고
    • Urinary excretion of homocysteine-thiolactone in humans
    • DOI 10.1373/clinchem.2004.042531
    • Chwatko G, Jakubowski H (2005b) Urinary excretion of homocysteine- thiolactone in humans. Clin Chem 51:408-415 (Pubitemid 40175812)
    • (2005) Clinical Chemistry , vol.51 , Issue.2 , pp. 408-415
    • Chwatko, G.1    Jakubowski, H.2
  • 4
    • 34249775796 scopus 로고    scopus 로고
    • Mutations in methylenetetrahydrofolate reductase or cystathionine beta-syntase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice
    • DOI 10.1096/fj.06-7435com
    • Chwatko G, Boers GH, Strauss KA, Shih DM, Jakubowski H (2007) Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J 21:1707-1713 (Pubitemid 46855616)
    • (2007) FASEB Journal , vol.21 , Issue.8 , pp. 1707-1713
    • Chwatko, G.1    Boers, G.H.J.2    Strauss, K.A.3    Shih, D.M.4    Jakubowski, H.5
  • 6
    • 0030803431 scopus 로고    scopus 로고
    • Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats
    • DOI 10.1006/exnr.1997.6464
    • Folbergrova J (1997) Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. Exp Neurol 145:442-450 (Pubitemid 27314795)
    • (1997) Experimental Neurology , vol.145 , Issue.2 , pp. 442-450
    • Folbergrova, J.1
  • 7
    • 2442641844 scopus 로고    scopus 로고
    • 34 and lysine residues in human serum albumin revealed by n-homocysteinylation
    • DOI 10.1074/jbc.M313268200
    • Glowacki R, Jakubowski H (2004) Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation. J Biol Chem 279:10864-10871 (Pubitemid 38401576)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.12 , pp. 10864-10871
    • Glowacki, R.1    Jakubowski, H.2
  • 8
    • 78449301117 scopus 로고    scopus 로고
    • Identification and origin of Ne-homocysteinyl-lysine isopeptide in humans and mice
    • Glowacki R, Bald E, Jakubowski H (2010) Identification and origin of Ne-homocysteinyl-lysine isopeptide in humans and mice. Amino Acids 39:1563-1569
    • (2010) Amino Acids , vol.39 , pp. 1563-1569
    • Glowacki, R.1    Bald, E.2    Jakubowski, H.3
  • 9
    • 58149352709 scopus 로고    scopus 로고
    • Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2 diabetes mellitus
    • Gu W, Lu J, Yang G, Dou J, Mu Y, Meng J, Pan C (2008) Plasma homocysteine thiolactone associated with risk of macrovasculopathy in Chinese patients with type 2 diabetes mellitus. Adv Ther 25:914-924
    • (2008) Adv Ther , vol.25 , pp. 914-924
    • Gu, W.1    Lu, J.2    Yang, G.3    Dou, J.4    Mu, Y.5    Meng, J.6    Pan, C.7
  • 10
    • 0016390789 scopus 로고
    • Homocystinemia. Vascular injury and arterial thrombosis
    • Harker LA, Slichter SJ, Scott CR, Ross R (1974) Homocystinemia. Vascular injury and arterial thrombosis. N Engl J Med 291:537-543
    • (1974) N Engl J Med , vol.291 , pp. 537-543
    • Harker, L.A.1    Slichter, S.J.2    Scott, C.R.3    Ross, R.4
  • 11
    • 0025371584 scopus 로고
    • Proofreading in vivo: Editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli
    • Jakubowski H (1990) Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli. Proc Natl Acad Sci USA 87:4504-4508
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4504-4508
    • Jakubowski, H.1
  • 12
    • 0031035742 scopus 로고    scopus 로고
    • Metabolism of homocysteine thiolactone in human cell cultures: Possible mechanism for pathological consequences of elevated homocysteine levels
    • Jakubowski H (1997) Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J Biol Chem 272:1935-1942 (Pubitemid 27043288)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.3 , pp. 1935-1942
    • Jakubowski, H.1
  • 13
    • 0032778517 scopus 로고    scopus 로고
    • Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels
    • Jakubowski H (1999) Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 13:2277-2283
    • (1999) FASEB J , vol.13 , pp. 2277-2283
    • Jakubowski, H.1
  • 14
    • 0033981289 scopus 로고    scopus 로고
    • Homocysteine thiolactone: Metabolic origin and protein homocysteinylation in humans
    • JakubowskiH(2000a) Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr 130:377S-381S (Pubitemid 30073754)
    • (2000) Journal of Nutrition , vol.130 , Issue.2 SUPPL.
    • Jakubowski, H.1
  • 15
    • 0034635449 scopus 로고    scopus 로고
    • Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation
    • DOI 10.1074/jbc.275.6.3957
    • Jakubowski H (2000b) Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J Biol Chem 275:3957-3962 (Pubitemid 30094622)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.6 , pp. 3957-3962
    • Jakubowski, H.1
  • 16
    • 0037163003 scopus 로고    scopus 로고
    • Homocysteine is a protein amino acid in humans: Implications for homocysteine-linked disease
    • DOI 10.1074/jbc.C200267200
    • Jakubowski H (2002) Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease. J Biol Chem 277:30425-30428 (Pubitemid 34970732)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 30425-30428
    • Jakubowski, H.1
  • 17
    • 33750550442 scopus 로고    scopus 로고
    • Mechanism of the condensation of homocysteine thiolactone with aldehydes
    • DOI 10.1002/chem.200600785
    • Jakubowski H (2006) Mechanism of the condensation of homocysteine thiolactone with aldehydes. Chemistry 12:8039-8043 (Pubitemid 44672724)
    • (2006) Chemistry - A European Journal , vol.12 , Issue.31 , pp. 8039-8043
    • Jakubowski, H.1
  • 18
    • 34548624195 scopus 로고    scopus 로고
    • Facile syntheses of [35S]homocysteine-thiolactone, [35S]homocystine, [35S]homocysteine, and [S-nitroso-35S]homocysteine
    • Jakubowski H (2007) Facile syntheses of [35S]homocysteine-thiolactone, [35S]homocystine, [35S]homocysteine, and [S-nitroso-35S]homocysteine. Anal Biochem 370:124-126
    • (2007) Anal Biochem , vol.370 , pp. 124-126
    • Jakubowski, H.1
  • 19
    • 64049095638 scopus 로고    scopus 로고
    • The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease
    • Jakubowski H (2008a) The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease. J Physiol Pharmacol 59(Suppl 9):155-167
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 9 , pp. 155-167
    • Jakubowski, H.1
  • 20
    • 47749089308 scopus 로고    scopus 로고
    • New method for the determination of protein N-linked homocysteine
    • Jakubowski H (2008b) New method for the determination of protein N-linked homocysteine. Anal Biochem 380:257-261
    • (2008) Anal Biochem , vol.380 , pp. 257-261
    • Jakubowski, H.1
  • 21
    • 79960144684 scopus 로고    scopus 로고
    • Quality control in tRNA charging-editing of homocysteine
    • Jakubowski H (2011) Quality control in tRNA charging-editing of homocysteine. Acta Biochim Pol 58:149-163
    • (2011) Acta Biochim Pol , vol.58 , pp. 149-163
    • Jakubowski, H.1
  • 22
    • 0027534543 scopus 로고
    • Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells
    • DOI 10.1016/0014-5793(93)81283-6
    • Jakubowski H, Goldman E (1993) Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells. FEBS Lett 317:237-240 (Pubitemid 23045796)
    • (1993) FEBS Letters , vol.317 , Issue.3 , pp. 237-240
    • Jakubowski, H.1    Goldman, E.2
  • 23
    • 0034617073 scopus 로고    scopus 로고
    • Homocysteine thiolactone and protein homocysteinylation in human endothelial cells implications for atherosclerosis
    • Jakubowski H, Zhang L, Bardeguez A, Aviv A (2000) Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis. Circ Res 87:45-51 (Pubitemid 30456934)
    • (2000) Circulation Research , vol.87 , Issue.1 , pp. 45-51
    • Jakubowski, H.1    Zhang, L.2    Bardeguez, A.3    Aviv, A.4
  • 24
    • 57349180605 scopus 로고    scopus 로고
    • Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans
    • Jakubowski H, Boers GH, Strauss KA (2008) Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans. FASEB J 22:4071-4076
    • (2008) FASEB J , vol.22 , pp. 4071-4076
    • Jakubowski, H.1    Boers, G.H.2    Strauss, K.A.3
  • 26
    • 33646402652 scopus 로고    scopus 로고
    • Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase
    • Kajiya A, Kaji H, Isobe T, Takeda A (2006) Processing of amyloid beta-peptides by neutral cysteine protease bleomycin hydrolase. Protein Pept Lett 13:119-123
    • (2006) Protein Pept Lett , vol.13 , pp. 119-123
    • Kajiya, A.1    Kaji, H.2    Isobe, T.3    Takeda, A.4
  • 28
    • 67649730096 scopus 로고    scopus 로고
    • Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids
    • Kamata Y, Taniguchi A, Yamamoto M, Nomura J, Ishihara K, Takahara H, Hibino T, Takeda A (2009) Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids. J Biol Chem 284:12829-12836
    • (2009) J Biol Chem , vol.284 , pp. 12829-12836
    • Kamata, Y.1    Taniguchi, A.2    Yamamoto, M.3    Nomura, J.4    Ishihara, K.5    Takahara, H.6    Hibino, T.7    Takeda, A.8
  • 30
    • 0000167774 scopus 로고    scopus 로고
    • Disorders of transsulfuration
    • Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B (eds) . Mc Graw-Hill, New York
    • Mudd SH, Levy HL, Krauss JP (2001) Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B (eds) The metabolic and molecular bases of inherited disease, vol 2. Mc Graw-Hill, New York, pp 2007-2056
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , vol.2 , pp. 2007-2056
    • Mudd, S.H.1    Levy, H.L.2    Krauss, J.P.3
  • 33
    • 77952294286 scopus 로고    scopus 로고
    • Paraoxonase 1 protects against protein N-homocysteinylation in humans
    • Perla-Kajan J, Jakubowski H (2010) Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB J 24:931-936
    • (2010) FASEB J , vol.24 , pp. 931-936
    • Perla-Kajan, J.1    Jakubowski, H.2
  • 34
    • 34249725607 scopus 로고    scopus 로고
    • Modification by homocysteine thiolactone affects redox status of cytochrome c
    • DOI 10.1021/bi602463m
    • Perla-Kajan J, Marczak L, Kajan L, Skowronek P, Twardowski T, Jakubowski H (2007) Modification by homocysteine thiolactone affects redox status of cytochrome C. Biochemistry 46:6225-6231 (Pubitemid 46842865)
    • (2007) Biochemistry , vol.46 , Issue.21 , pp. 6225-6231
    • Perla-Kajan, J.1    Marczak, L.2    Kajan, L.3    Skowronek, P.4    Twardowski, T.5    Jakubowski, H.6
  • 37
    • 33644553466 scopus 로고    scopus 로고
    • Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: A potential mechanism of the thrombotic tendency in hyperhomocysteinemia
    • Sauls DL, Lockhart E, Warren ME, Lenkowski A, Wilhelm SE, Hoffman M (2006) Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia. Biochemistry 45:2480-2487
    • (2006) Biochemistry , vol.45 , pp. 2480-2487
    • Sauls, D.L.1    Lockhart, E.2    Warren, M.E.3    Lenkowski, A.4    Wilhelm, S.E.5    Hoffman, M.6
  • 39
    • 78649409678 scopus 로고    scopus 로고
    • B vitamins and the aging brain
    • Selhub J, Troen A, Rosenberg IH (2010) B vitamins and the aging brain. Nutr Rev 68(Suppl 2):S112-S118
    • (2010) Nutr Rev , vol.68 , Issue.SUPPL. 2
    • Selhub, J.1    Troen, A.2    Rosenberg, I.H.3
  • 41
    • 48249091668 scopus 로고    scopus 로고
    • The worldwide challenge of the dementias: A role for B vitamins and homocysteine?
    • Smith AD (2008) The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr Bull 29:S143-S172
    • (2008) Food Nutr Bull , vol.29
    • Smith, A.D.1
  • 43
    • 0029035707 scopus 로고
    • Toxicity, biodistribution and radioprotective capacity of Lhomocysteine thiolactone in CNS tissues and tumors in rodents: Comparison with prior results with phosphorothioates
    • Spence AM, Rasey JS, Dwyer-Hansen L, Grunbaum Z, Livesey J, Chin L, Nelson N, Stein D, Krohn KA, Ali-Osman F (1995) Toxicity, biodistribution and radioprotective capacity of Lhomocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. Radiother Oncol 35:216-226
    • (1995) Radiother Oncol , vol.35 , pp. 216-226
    • Spence, A.M.1    Rasey, J.S.2    Dwyer-Hansen, L.3    Grunbaum, Z.4    Livesey, J.5    Chin, L.6    Nelson, N.7    Stein, D.8    Krohn, K.A.9    Ali-Osman, F.10
  • 44
    • 0014696042 scopus 로고
    • Convulsant activity of homocysteine and other short-chain mercaptoacids: Protection therefrom
    • Sprince H, Parker CM, Josephs JA Jr, Magazino J (1969) Convulsant activity of homocysteine and other short-chain mercaptoacids: protection therefrom. Ann N Y Acad Sci 166:323-325
    • (1969) Ann N y Acad Sci , vol.166 , pp. 323-325
    • Sprince, H.1    Parker, C.M.2    Josephs Jr., J.A.3    Magazino, J.4
  • 46
    • 2542618547 scopus 로고    scopus 로고
    • Autoantibodies against N-homocysteinylated proteins in humans: Implications for atherosclerosis
    • DOI 10.1161/01.STR.0000128412.59768.6e
    • Undas A, Perla J, Lacinski M, Trzeciak W, Kazmierski R, Jakubowski H (2004) Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis. Stroke 35:1299-1304 (Pubitemid 38697447)
    • (2004) Stroke , vol.35 , Issue.6 , pp. 1299-1304
    • Undas, A.1    Perla, J.2    Lacinski, M.3    Trzeciak, W.4    Kazmierski, R.5    Jakubowski, H.6
  • 47
    • 13844253976 scopus 로고    scopus 로고
    • Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men
    • DOI 10.1160/TH04-08-0493
    • Undas A, Jankowski M, Twardowska M, Padjas A, Jakubowski H, Szczeklik A (2005) Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men. Thromb Haemost 93:346-350 (Pubitemid 40253742)
    • (2005) Thrombosis and Haemostasis , vol.93 , Issue.2 , pp. 346-350
    • Undas, A.1    Jankowski, M.2    Twardowska, M.3    Padjas, A.4    Jakubowski, H.5    Szczeklik, A.6
  • 48
    • 43249103554 scopus 로고    scopus 로고
    • Dietary methionine effects on plasma homocysteine and HDL metabolism in mice
    • DOI 10.1016/j.jnutbio.2007.05.005, PII S0955286307001374
    • Velez-Carrasco W, Merkel M, Twiss CO, Smith JD (2008) Dietary methionine effects on plasma homocysteine and HDL metabolism in mice. J Nutr Biochem 19:362-370 (Pubitemid 351685662)
    • (2008) Journal of Nutritional Biochemistry , vol.19 , Issue.6 , pp. 362-370
    • Velez-Carrasco, W.1    Merkel, M.2    Twiss, C.O.3    Smith, J.D.4
  • 49
    • 31044453984 scopus 로고    scopus 로고
    • Plasma homocysteine thiolactone adducts associated with risk of coronary heart disease
    • DOI 10.1016/j.cccn.2005.07.007, PII S0009898105004213
    • Yang X, Gao Y, Zhou J, Zhen Y, Yang Y, Wang J, Song L, Liu Y, Xu H, Chen Z, Hui R (2006) Plasma homocysteine thiolactone adducts associated with risk of coronary heart disease. Clin Chim Acta 364:230-234 (Pubitemid 43120647)
    • (2006) Clinica Chimica Acta , vol.364 , Issue.1-2 , pp. 230-234
    • Yang, X.1    Gao, Y.2    Zhou, J.3    Zhen, Y.4    Yang, Y.5    Wang, J.6    Song, L.7    Liu, Y.8    Xu, H.9    Chen, Z.10    Hui, R.11
  • 50
    • 79954538856 scopus 로고    scopus 로고
    • Elevated concentrations of Ne-homocysteinyl-lysine isopeptide in acute myocardial infarction: Links with ADMA formation
    • Zabczyk M, Glowacki R, Machnik A, Herod P, Kazek G, Jakubowski H, Undas A (2011) Elevated concentrations of Ne-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation. Clin Chem Lab Med 49:729-735
    • (2011) Clin Chem Lab Med , vol.49 , pp. 729-735
    • Zabczyk, M.1    Glowacki, R.2    MacHnik, A.3    Herod, P.4    Kazek, G.5    Jakubowski, H.6    Undas, A.7
  • 52
    • 33747355994 scopus 로고    scopus 로고
    • Protective mechanisms against homocysteine toxicity: The role of bleomycin hydrolase
    • Zimny J, Sikora M, Guranowski A, Jakubowski H (2006) Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. J Biol Chem 281:22485-22492
    • (2006) J Biol Chem , vol.281 , pp. 22485-22492
    • Zimny, J.1    Sikora, M.2    Guranowski, A.3    Jakubowski, H.4


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