Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease

Molecular Psychiatry

Volumn 5, Issue 2, 2000, Pages 213-215

  Papassotiropoulos, A ^a   Bagli, M ^a   Jessen, F ^a   Frahnert, C ^a   Rao, M L ^a   Maier, W ^a   Heun, R ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Alzheimer's disease; Association; Beta secretase; Bleomycin hydrolase; Case control study; Polymorphism

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; BLEOMYCIN HYDROLASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RISK FACTOR;

EID: 0034053536     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000656     Document Type: Article

References (9)

1. 1 London CL, Ashall F, Goate AM. Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 1997; 277: 825-831.
2. 2 Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 1998; 51 (Suppl 1): 2-17.
3. 3 Bromme D, Rossi AB, Smeekens SP, Anderson DC, Payan DG. Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Biochemistry 1996; 35: 6706-6714.
4. 4 Montoya SE, Aston CE, DeKosky ST, Kamboh MI, Lazo JS, Ferrell RE. Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. Nat Genet 1998; 18: 211-212.
5. 5 Farrer LA, Abraham CR, Haines JL et al. Association between bleomycin hydrolase and Alzheimer's disease in Caucasians. Ann Neurol 1998; 44: 808-811.
6. 6 Sackett DL. Bias in analytic research. J Chronic Dis 1979; 32: 51-63.
7. 7 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
8. 8 Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res 1990; 31: 545-548.
9. 9 Montoya SE, Ferrell RE, Lazo JS. Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. Cancer Res 1997; 57: 4191-4195.