Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: A crucial role of CD25-FOXP3- T cells

International Journal of Cancer

Volumn 131, Issue 11, 2012, Pages 2573-2583

  Kakita, Naruyasu ^a   Kanto, Tatsuya ^a   Itose, Ichiyo ^b   Kuroda, Shoko ^a   Inoue, Michiyo ^a   Matsubara, Tokuhiro ^a   Higashitani, Koyo ^a   Miyazaki, Masanori ^a   Sakakibara, Mitsuru ^a   Hiramatsu, Naoki ^a   Takehara, Tetsuo ^a   Kasahara, Akinori ^c   Hayashi, Norio ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANSAI ROSAI HOSPITAL   (Japan)

^c OSAKA UNIVERSITY HOSPITAL   (Japan)

Author keywords

CD127; CD25; FOXP3; HCC; regulatory T cells

Indexed keywords

CD4 ANTIGEN; CELL ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN LIKE TRANSCRIPT 4; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; LEUCOCYTE ANTIGEN G; PROGRAMMED DEATH 1 LIGAND 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ABLATION THERAPY; ADULT; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER RECURRENCE; CD4+ T LYMPHOCYTE; CELL CULTURE; CHRONIC LIVER DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DYNAMICS; FEASIBILITY STUDY; FEMALE; GENE EXPRESSION PROFILING; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

AGED; ANTIGENS, CD274; CARCINOMA, HEPATOCELLULAR; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; DENDRITIC CELLS; DISEASE PROGRESSION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS C; HLA ANTIGENS; HUMANS; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LIVER NEOPLASMS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTES, REGULATORY;

EID: 84867045833     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27535     Document Type: Article

References (32)

1. Parkin DM, Bray F, Ferlay J, Pisani P,. Estimating the world cancer burden: globocan 2000. Int J Cancer 2001; 94: 153-6.
2. Bruix J, Sherman M,. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
3. Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB,. Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology 2004; 127: 1372-80.
4. Sakaguchi S, Yamaguchi T, Nomura T, Ono M,. Regulatory T cells and immune tolerance. Cell 2008; 133: 775-87.
5. Jonuleit H, Schmitt E,. The regulatory T cell family: distinct subsets and their interrelations. J Immunol 2003; 171: 6323-7.
6. Liyanage UK, Moore TT, Joo HG, Tanaka Y, Herrmann V, Doherty G, Drebin JA, Strasberg SM, Eberlein TJ, Goedegebuure PS, Linehan DC,. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 2002; 169: 2756-61.
7. Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, Korangy F,. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 2005; 65: 2457-64.
8. Fu J, Xu D, Liu Z, Shi M, Zhao P, Fu B, Zhang Z, Yang H, Zhang H, Zhou C, Yao J, Jin L, et al. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 2007; 132: 2328-39.
9. Hori S, Nomura T, Sakaguchi S,. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
10. Ziegler SF,. FOXP3: of mice and men. Annu Rev Immunol 2006; 24: 209-26.
11. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701-11.
12. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R, Kelleher A, Fazekas de St Groth B,. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203: 1693-700.
13. Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM,. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007; 319: 41-52.
14. Haringer B, Lozza L, Steckel B, Geginat J,. Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood. J Exp Med 2009; 206: 1009-17.
15. Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM,. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. PLoS Pathog 2008; 4: e1000004.
16. Arii S, Sata M, Sakamoto M, Shimada M, Kumada T, Shiina S, Yamashita T, Kokudo N, Tanaka M, Takayama T, Kudo M,. Management of hepatocellular carcinoma: Report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res 2010; 40: 667-85.
17. Itose I, Kanto T, Kakita N, Takebe S, Inoue M, Higashitani K, Miyazaki M, Miyatake H, Sakakibara M, Hiramatsu N, Takehara T, Kasahara A, et al. Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis. J Viral Hepat 2009; 16: 844-52.
18. Kanto T, Hayashi N, Takehara T, Tatsumi T, Kuzushita N, Ito A, Sasaki Y, Kasahara A, Hori M,. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 1999; 162: 5584-91.
19. Mahnke K, Schonfeld K, Fondel S, Ring S, Karakhanova S, Wiedemeyer K, Bedke T, Johnson TS, Storn V, Schallenberg S, Enk AH,. Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer 2007; 120: 2723-33.
20. Ruter J, Barnett BG, Kryczek I, Brumlik MJ, Daniel BJ, Coukos G, Zou W, Curiel TJ,. Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines. Front Biosci 2009; 14: 1761-70.
21. Elrefaei M, Burke CM, Baker CA, Jones NG, Bousheri S, Bangsberg DR, Cao H,. HIV-specific TGF-beta-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4. Aids Res Hum Retroviruses 2010; 26: 329-37.
22. Han Y, Guo Q, Zhang M, Chen Z, Cao X,. CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol 2009; 182: 111-20.
23. Li R, Perez N, Karumuthil-Melethil S, Prabhakar BS, Holterman MJ, Vasu C,. Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells. J Immunol 2007; 179: 5191-203.
24. + T cell subsets that are differentially depleted during HIV infection. J Immunol 2008; 180: 5582-5592.
25. + T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 2007; 81: 945-953.
26. Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK,. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 2009; 183: 797-801.
27. Chen KJ, Lin SZ, Zhou L, Xie HY, Zhou WH, Taki-Elden A, Zheng SS,. Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. PLOS One 2011; 6: e24671.
28. Zhou J, Ding T, Pan W, Zhu LY, Li L, Zheng L,. Increased intratumoralregulatory T cells are related to intratumoral macrophage and poor prognosis in hepatocellular carcinoma patients. Int J Cancer 2009; 125: 1640-8.
29. Bergmann C, Strauss L, Zeidler R, Lang S, Whiteside TL,. Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment. Cancer Immunol Immunother 2007; 56: 1429-42.
30. Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, Hauben E, Roncarolo MG,. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010; 116: 935-44.
31. Gao Q, Wang XY, Qiu SJ, Yamato I, Sho M, Nakajima Y, Zhou J, Li BZ, Shi YH, Xiao YS, Xu Y, Fan J,. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 2009; 15: 971-9.
32. Cai MY, Xu YF, Qiu SJ, Ju MJ, Gao Q, Li YW, Zhang BH, Zhou J, Fan J,. Human leukocyte antigen-G protein expression is an unfavorable prognostic predictor of hepatocellular carcinoma following curative resection. Clin Cancer Res 2009; 15: 4686-93.