Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 85-101

  Ihmaid, Saleh K ^a   Al Rawi, Jasim M A ^a   Bradley, Christopher J ^a   Angove, Michael J ^a   Robertson, Murray N ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

2 Amino substituted 1,3 benzoxazines; Anti platelet activity; DNA PK; Homology modelling; PI3K inhibition; Synthesis

Indexed keywords

1,3 BENZOXAZINE DERIVATIVE; 2 [PYRIDIN 3 YL (PYRIDIN 3 YLMETHYL)AMINO] 7 (PYRIDIN 3 YLMETHOXY) 4H BENZ[E][1,3]OXAZIN 4 ONE; 2 [PYRIDIN 3 YL (PYRIDIN 3 YLMETHYL)AMINO] 8 (PYRIDIN 3 YLMETHOXY) 4H BENZ[E][1,3]OXAZIN 4 ONE; 7 (PYRIDIN 2 YLMETHOXY) 2 [(PYRIDIN 2 YLMETHYL)(PYRIDIN 3 YL)AMINO] 4H BENZO[E][1,3]OXAZIN 4 ONE; 8 (PYRIDIN 2 YLMETHOXY) 2 [(PYRIDIN 2 YLMETHYL)(PYRIDIN 3 YL)AMINO] 4H BENZ[E][1,3]OXAZIN 4 ONE; 8 METHYL 2 [PYRIDIN 3 YL (PYRIDIN 2 YLMETHYL)AMINO] 4H BENZ[E] 1,3 OXAZIN 4 ONE; 8 METHYL 2 [PYRIDIN 3 YL (PYRIDIN 3 YLMETHYL)AMINO] 7 (PYRIDIN 3 YLMETHOXY) 4H BENZ[E] 1,3 OXAZIN 4 ONE; ANTITHROMBOCYTIC AGENT; BENZOXAZINE DERIVATIVE; COLLAGEN; DNA DEPENDENT PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; X RAY CRYSTALLOGRAPHY;

BENZOXAZINES; BLOOD PLATELETS; COLLAGEN; CRYSTALLOGRAPHY, X-RAY; DNA-ACTIVATED PROTEIN KINASE; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; PHOSPHATIDYLINOSITOL 3-KINASES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867043713     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.035     Document Type: Article

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