8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4885-4890

  Murr, Marine Desage El ^a   Cano, Celine ^a   Golding, Bernard T ^a   Hardcastle, Ian R ^a   Hummersome, Marc ^b   Frigerio, Mark ^b   Curtin, Nicola J ^a   Menear, Keith ^b   Richardson, Caroline ^b   Smith, Graeme C M ^b   Griffin, Roger J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b KuDOS Pharmaceuticals Ltd   (United Kingdom)

Author keywords

Cancer; Chromenones; DNA PK; DNA repair; Kinase inhibitor

Indexed keywords

CHROMENE DERIVATIVE; DNA DEPENDENT PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CHROMONES; DNA-ACTIVATED PROTEIN KINASE; HELA CELLS; HUMANS; PROTEIN KINASE INHIBITORS; RADIATION-SENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 49849088557     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.066     Document Type: Article

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