메뉴 건너뛰기




Volumn 7, Issue 10, 2012, Pages

Neurofibrillary Tangles and the Deposition of a Beta Amyloid Peptide with a Novel N-Terminal Epitope in the Brains of Wild Tsushima Leopard Cats

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; TAU PROTEIN;

EID: 84867043636     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046452     Document Type: Article
Times cited : (26)

References (57)
  • 1
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ, (2006) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 19 297: 353-6.
    • (2006) Science 19 , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 2
    • 77952572748 scopus 로고    scopus 로고
    • Distribution of neprilysin and deposit patterns of Abeta subtypes in the brains of aged squirrel monkeys (Saimiri sciureus)
    • Chambers JK, Kuribayashi H, Ikeda S, Une Y, (2010) Distribution of neprilysin and deposit patterns of Abeta subtypes in the brains of aged squirrel monkeys (Saimiri sciureus). Amyloid 17: 75-82.
    • (2010) Amyloid , vol.17 , pp. 75-82
    • Chambers, J.K.1    Kuribayashi, H.2    Ikeda, S.3    Une, Y.4
  • 4
    • 0032176674 scopus 로고    scopus 로고
    • Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys
    • Nakamura S, Nakayama H, Goto N, Ono F, Sakakibara I, et al. (1998) Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys. J Med Primatol 27: 244-52.
    • (1998) J Med Primatol , vol.27 , pp. 244-252
    • Nakamura, S.1    Nakayama, H.2    Goto, N.3    Ono, F.4    Sakakibara, I.5
  • 6
    • 0026941783 scopus 로고
    • Immunohistochemical analysis of constituents of senile plaques and cerebro-vascular amyloid in aged dogs
    • Uchida K, Nakayama H, Tateyama S, Goto N, (1992) Immunohistochemical analysis of constituents of senile plaques and cerebro-vascular amyloid in aged dogs. J Vet Med Sci 54: 1023-9.
    • (1992) J Vet Med Sci , vol.54 , pp. 1023-1029
    • Uchida, K.1    Nakayama, H.2    Tateyama, S.3    Goto, N.4
  • 8
    • 84856803616 scopus 로고    scopus 로고
    • Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain
    • Mutsuga M, Chambers JK, Uchida K, Tei M, Makibuchi T, et al. (2012) Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain. J Vet Med Sci 74: 51-7.
    • (2012) J Vet Med Sci , vol.74 , pp. 51-57
    • Mutsuga, M.1    Chambers, J.K.2    Uchida, K.3    Tei, M.4    Makibuchi, T.5
  • 9
    • 64549150594 scopus 로고    scopus 로고
    • Natural non-trasgenic animal models for research in Alzheimer's disease
    • Sarasa M, Pesini P, (2009) Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6: 171-8.
    • (2009) Curr Alzheimer Res , vol.6 , pp. 171-178
    • Sarasa, M.1    Pesini, P.2
  • 11
    • 84857659979 scopus 로고    scopus 로고
    • Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)
    • Serizawa S, Chambers JK, Une Y, (2012) Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus). Vet Pathol 49: 304-12.
    • (2012) Vet Pathol , vol.49 , pp. 304-312
    • Serizawa, S.1    Chambers, J.K.2    Une, Y.3
  • 12
    • 84859325175 scopus 로고    scopus 로고
    • Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia
    • Ferrer I, (2012) Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia. Prog Neurobiol 97: 38-51.
    • (2012) Prog Neurobiol , vol.97 , pp. 38-51
    • Ferrer, I.1
  • 13
    • 3242763888 scopus 로고    scopus 로고
    • A comparative study of age-related brain pathology-are neurodegenerative diseases present in nonhuman animals?
    • Nakayama H, Uchida K, Doi K, (2004) A comparative study of age-related brain pathology-are neurodegenerative diseases present in nonhuman animals? Med Hypotheses 63: 198-202.
    • (2004) Med Hypotheses , vol.63 , pp. 198-202
    • Nakayama, H.1    Uchida, K.2    Doi, K.3
  • 15
    • 79955801619 scopus 로고    scopus 로고
    • Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species
    • Chambers JK, Mutsuga M, Uchida K, Nakayama H, (2011) Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species. Amyloid 18: 63-71.
    • (2011) Amyloid , vol.18 , pp. 63-71
    • Chambers, J.K.1    Mutsuga, M.2    Uchida, K.3    Nakayama, H.4
  • 16
    • 0025853543 scopus 로고
    • Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis
    • Johnstone EM, Chaney MO, Norris FH, Pascual R, Little SP, (1991) Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res 10: 299-305.
    • (1991) Brain Res Mol Brain Res , vol.10 , pp. 299-305
    • Johnstone, E.M.1    Chaney, M.O.2    Norris, F.H.3    Pascual, R.4    Little, S.P.5
  • 17
    • 0023118252 scopus 로고
    • Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease
    • Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC, (1987) Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science 20 235: 873-7.
    • (1987) Science 20 , vol.235 , pp. 873-877
    • Selkoe, D.J.1    Bell, D.S.2    Podlisny, M.B.3    Price, D.L.4    Cork, L.C.5
  • 18
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease and frontotemporal dementia
    • Götz J, Ittner LM, (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 9: 532-44.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 532-544
    • Götz, J.1    Ittner, L.M.2
  • 19
    • 0029383728 scopus 로고
    • Two Japanese wildcats, the Tsushima cat and the Iriomote cat, show the same mitochondrial DNA lineage as the leopard cat Felis bengalensis
    • Masuda R, Yoshida MC, (1995) Two Japanese wildcats, the Tsushima cat and the Iriomote cat, show the same mitochondrial DNA lineage as the leopard cat Felis bengalensis. Zoolog Sci 12: 655-9.
    • (1995) Zoolog Sci , vol.12 , pp. 655-659
    • Masuda, R.1    Yoshida, M.C.2
  • 20
    • 71149095450 scopus 로고    scopus 로고
    • Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies
    • Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, et al. (2010) Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. J Comp Pathol 142: 61-73.
    • (2010) J Comp Pathol , vol.142 , pp. 61-73
    • Capucchio, M.T.1    Márquez, M.2    Pregel, P.3    Foradada, L.4    Bravo, M.5
  • 21
    • 0029120313 scopus 로고
    • Senile plaques in an aged two-humped (Bactrian) camel (Camelus bactrianus)
    • Nakamura S, Nakayama H, Uetsuka K, Sasaki N, Uchida K, et al. (1995) Senile plaques in an aged two-humped (Bactrian) camel (Camelus bactrianus). Acta Neuropathol 90: 415-8.
    • (1995) Acta Neuropathol , vol.90 , pp. 415-418
    • Nakamura, S.1    Nakayama, H.2    Uetsuka, K.3    Sasaki, N.4    Uchida, K.5
  • 22
    • 0025440901 scopus 로고
    • Amyloid angiopathy with cerebral hemorrhage and senile plaque in aged dogs
    • Uchida K, Miyauchi Y, Nakayama H, Goto N, (1990) Amyloid angiopathy with cerebral hemorrhage and senile plaque in aged dogs. Nihon Juigaku Zasshi 52: 605-11.
    • (1990) Nihon Juigaku Zasshi , vol.52 , pp. 605-611
    • Uchida, K.1    Miyauchi, Y.2    Nakayama, H.3    Goto, N.4
  • 23
    • 0029339834 scopus 로고
    • Senile plaques and other senile changes in the brain of an aged American black bear
    • Uchida K, Yoshino T, Yamaguchi R, Tateyama S, Kimoto Y, et al. (1995) Senile plaques and other senile changes in the brain of an aged American black bear. Vet Pathol 32: 412-4.
    • (1995) Vet Pathol , vol.32 , pp. 412-414
    • Uchida, K.1    Yoshino, T.2    Yamaguchi, R.3    Tateyama, S.4    Kimoto, Y.5
  • 26
    • 26644445247 scopus 로고    scopus 로고
    • beta-amyloid is different in normal aging and in Alzheimer disease
    • Piccini A, Russo C, Gliozzi A, Relini A, Vitali A, et al. (2005) beta-amyloid is different in normal aging and in Alzheimer disease. J Biol Chem 280: 34186-92.
    • (2005) J Biol Chem , vol.280 , pp. 34186-34192
    • Piccini, A.1    Russo, C.2    Gliozzi, A.3    Relini, A.4    Vitali, A.5
  • 27
    • 33749617597 scopus 로고    scopus 로고
    • On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)
    • Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, et al. (2006) On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry 45: 12393-9.
    • (2006) Biochemistry , vol.45 , pp. 12393-12399
    • Schilling, S.1    Lauber, T.2    Schaupp, M.3    Manhart, S.4    Scheel, E.5
  • 28
    • 53549099647 scopus 로고    scopus 로고
    • Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology
    • Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, et al. (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med 14: 1106-11.
    • (2008) Nat Med , vol.14 , pp. 1106-1111
    • Schilling, S.1    Zeitschel, U.2    Hoffmann, T.3    Heiser, U.4    Francke, M.5
  • 29
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E, (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathology 82: 239-59.
    • (1991) Acta Neuropathology , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 30
    • 80054024011 scopus 로고    scopus 로고
    • Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
    • Jucker M, Walker LC, (2011) Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 70: 532-40.
    • (2011) Ann Neurol , vol.70 , pp. 532-540
    • Jucker, M.1    Walker, L.C.2
  • 31
    • 33748987057 scopus 로고    scopus 로고
    • Biochemistry and molecular biology of tauopathies
    • Hasegawa M, (2006) Biochemistry and molecular biology of tauopathies. Neuropathology 26: 484-90.
    • (2006) Neuropathology , vol.26 , pp. 484-490
    • Hasegawa, M.1
  • 32
    • 0031957225 scopus 로고    scopus 로고
    • Glial tau pathology in neurodegenerative diseases: their nature and comparison with neuronal tangles
    • Ikeda K, Akiyama H, Arai T, Nishimura T (1998) Glial tau pathology in neurodegenerative diseases: their nature and comparison with neuronal tangles. Neurobiol Aging 19(1 Suppl): S85-91.
    • (1998) Neurobiol Aging , vol.19 , Issue.1 SUPPL. , pp. 85-91
    • Ikeda, K.1    Akiyama, H.2    Arai, T.3    Nishimura, T.4
  • 33
    • 0029071320 scopus 로고
    • Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain
    • Nishimura M, Tomimoto H, Suenaga T, Namba Y, Ikeda K, et al. (1995) Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain. Am J Pathol 146: 1052-8.
    • (1995) Am J Pathol , vol.146 , pp. 1052-1058
    • Nishimura, M.1    Tomimoto, H.2    Suenaga, T.3    Namba, Y.4    Ikeda, K.5
  • 34
    • 0033142961 scopus 로고    scopus 로고
    • REVIEW: tau protein pathology in Alzheimer's disease and related disorders
    • Tolnay M, Probst A, (1999) REVIEW: tau protein pathology in Alzheimer's disease and related disorders. Neuropathol Appl Neurobiol 25: 171-87.
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 171-187
    • Tolnay, M.1    Probst, A.2
  • 35
    • 33749007666 scopus 로고    scopus 로고
    • Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies
    • Arima K, (2006) Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. Neuropathology 26: 475-83.
    • (2006) Neuropathology , vol.26 , pp. 475-483
    • Arima, K.1
  • 36
    • 0038170494 scopus 로고    scopus 로고
    • Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies
    • de Silva R, Lashley T, Gibb G, Hanger D, Hope A, et al. (2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathol Appl Neurobiol 29: 288-302.
    • (2003) Neuropathol Appl Neurobiol , vol.29 , pp. 288-302
    • de Silva, R.1    Lashley, T.2    Gibb, G.3    Hanger, D.4    Hope, A.5
  • 37
    • 48249148310 scopus 로고    scopus 로고
    • Tau exon 10 alternative splicing and tauopathies
    • Liu F, Gong CX, (2008) Tau exon 10 alternative splicing and tauopathies. Mol Neurodegener 3: 8.
    • (2008) Mol Neurodegener , vol.3 , pp. 8
    • Liu, F.1    Gong, C.X.2
  • 39
    • 0031935017 scopus 로고    scopus 로고
    • Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation
    • Delacourte A, Sergeant N, Wattez A, Gauvreau D, Robitaille Y, (1998) Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation. Ann Neurol 43: 193-204.
    • (1998) Ann Neurol , vol.43 , pp. 193-204
    • Delacourte, A.1    Sergeant, N.2    Wattez, A.3    Gauvreau, D.4    Robitaille, Y.5
  • 40
    • 0039575094 scopus 로고    scopus 로고
    • Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease
    • Buée L, Delacourte A, (1999) Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain Pathol 9: 681-93.
    • (1999) Brain Pathol , vol.9 , pp. 681-693
    • Buée, L.1    Delacourte, A.2
  • 42
    • 0025785076 scopus 로고
    • Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease
    • Jakes R, Novak M, Davison M, Wischik CM, (1991) Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease. EMBO J 10: 2725-9.
    • (1991) EMBO J , vol.10 , pp. 2725-2729
    • Jakes, R.1    Novak, M.2    Davison, M.3    Wischik, C.M.4
  • 43
    • 33748996792 scopus 로고    scopus 로고
    • Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies
    • Yoshida M, (2006) Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathology 26: 457-70.
    • (2006) Neuropathology , vol.26 , pp. 457-470
    • Yoshida, M.1
  • 44
    • 0022185841 scopus 로고
    • Immunological characterization of microtubule-associated proteins specific for the immature brain
    • Couchie D, Nunez J, (1985) Immunological characterization of microtubule-associated proteins specific for the immature brain. FEBS Lett 188: 331-5.
    • (1985) FEBS Lett , vol.188 , pp. 331-335
    • Couchie, D.1    Nunez, J.2
  • 45
    • 0024387161 scopus 로고
    • Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain
    • Goedert M, Spillantini MG, Potier MC, Ulrich J, Crowther RA, (1989) Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J 8: 393-9.
    • (1989) EMBO J , vol.8 , pp. 393-399
    • Goedert, M.1    Spillantini, M.G.2    Potier, M.C.3    Ulrich, J.4    Crowther, R.A.5
  • 46
    • 0025600995 scopus 로고
    • Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization
    • Goedert M, Jakes R, (1990) Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9: 4225-30.
    • (1990) EMBO J , vol.9 , pp. 4225-4230
    • Goedert, M.1    Jakes, R.2
  • 47
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • Hooper C, Killick R, Lovestone S, (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104: 1433-9.
    • (2008) J Neurochem , vol.104 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 48
    • 33846129434 scopus 로고    scopus 로고
    • Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
    • Leroy K, Yilmaz Z, Brion JP, (2007) Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol 33: 43-55.
    • (2007) Neuropathol Appl Neurobiol , vol.33 , pp. 43-55
    • Leroy, K.1    Yilmaz, Z.2    Brion, J.P.3
  • 49
    • 0029737421 scopus 로고    scopus 로고
    • Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II
    • Yamaguchi H, Ishiguro K, Uchida T, Takashima A, Lemere CA, et al. (1996) Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol 92: 232-41.
    • (1996) Acta Neuropathol , vol.92 , pp. 232-241
    • Yamaguchi, H.1    Ishiguro, K.2    Uchida, T.3    Takashima, A.4    Lemere, C.A.5
  • 50
    • 13144265717 scopus 로고    scopus 로고
    • Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
    • Takashima A, Murayama M, Murayama O, Kohno T, Honda T, et al. (1998) Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A 95: 9637-41.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9637-9641
    • Takashima, A.1    Murayama, M.2    Murayama, O.3    Kohno, T.4    Honda, T.5
  • 51
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
    • Caughey B, Lansbury PT, (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26: 267-98.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury, P.T.2
  • 52
    • 11144356498 scopus 로고    scopus 로고
    • Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
    • Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, et al. (2004) Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 24: 3801-9.
    • (2004) J Neurosci , vol.24 , pp. 3801-3809
    • Kawarabayashi, T.1    Shoji, M.2    Younkin, L.H.3    Wen-Lang, L.4    Dickson, D.W.5
  • 53
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, et al. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300(5618): 486-9.
    • (2003) Science , vol.300 , Issue.5618 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3    McIntire, T.M.4    Milton, S.C.5
  • 54
    • 67650729973 scopus 로고    scopus 로고
    • Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin
    • Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, et al. (2009) Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci 29: 9078-89.
    • (2009) J Neurosci , vol.29 , pp. 9078-9089
    • Ma, Q.L.1    Yang, F.2    Rosario, E.R.3    Ubeda, O.J.4    Beech, W.5
  • 55
    • 84863762839 scopus 로고    scopus 로고
    • Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
    • in press
    • Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, et al. (2012) Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature in press.
    • (2012) Nature
    • Nussbaum, J.M.1    Schilling, S.2    Cynis, H.3    Silva, A.4    Swanson, E.5
  • 56
    • 77950617631 scopus 로고    scopus 로고
    • A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
    • Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, et al. (2010) A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 30: 4845-56.
    • (2010) J Neurosci , vol.30 , pp. 4845-4856
    • Tomiyama, T.1    Matsuyama, S.2    Iso, H.3    Umeda, T.4    Takuma, H.5
  • 57
    • 79956320988 scopus 로고    scopus 로고
    • Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
    • Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, et al. (2011) Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biol Chem 27: 18414-25.
    • (2011) J Biol Chem , vol.27 , pp. 18414-18425
    • Jimenez, S.1    Torres, M.2    Vizuete, M.3    Sanchez-Varo, R.4    Sanchez-Mejias, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.