Turnover-dependent covalent inactivation of staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: Mechanistic and structural insights

Biochemistry

Volumn 51, Issue 39, 2012, Pages 7699-7711

  Wallace, Bret D ^a   Edwards, Jonathan S ^a,d   Wallen, Jamie R ^b,e   Moolman, Wessel J A ^c   Van Der Westhuyzen, Renier ^c   Strauss, Erick ^c   Redinbo, Matthew R ^a   Claiborne, Al ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d Massachusetts Institute of Technology   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PATHOGENS; BIOSYNTHETIC PATHWAY; CATALYTIC TURNOVER; CONFORMATIONAL SWITCHES; COVALENT LINKAGE; HETERODIMERS; INHIBITOR COMPLEX; INHIBITOR MOLECULES; KINETIC ANALYSIS; METABOLIC PROCESS; REDOX CENTERS; REDOX CYCLES; S. AUREUS; SIDE-CHAINS; STAPHYLOCOCCUS AUREUS; STRUCTURAL INSIGHTS; THERAPEUTIC POTENTIALS; VINYL SULFONES; WILD TYPES; WILD-TYPE ENZYMES;

BACTERIA; BIOSYNTHESIS; ENZYMES; REDOX REACTIONS;

FACTOR ANALYSIS;

CARBOXYL GROUP; COENZYME A; DIMER; HETERODIMER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE; STAPHYLOCCOCCUS AUREUS COENZYME A DISULFIDE REDUCTASE; SULFONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; MUTANT; PRIORITY JOURNAL; TURNOVER TIME; WILD TYPE;

ANTI-BACTERIAL AGENTS; COENZYME A; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; MUTATION; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; PROTEIN MULTIMERIZATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 84867037000     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301026c     Document Type: Article

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