Michael acceptor-containing coenzyme a analogues as inhibitors of the atypical coenzyme a disulfide reductase from staphylococcus aureus

Journal of the American Chemical Society

Volumn 132, Issue 37, 2010, Pages 12853-12855

  Van Der Westhuyzen, Renier ^a   Strauss, Erick ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CHEMO-ENZYMATIC SYNTHESIS; COENZYME A; CONJUGATE ADDITION; DISULFIDE REDUCTASE; DRUG TARGETS; ELECTROPHILIC SUBSTRATE; MICHAEL ACCEPTORS; POTENT INHIBITION; POTENTIAL INHIBITORS; SECOND ORDERS; STAPHYLOCOCCUS AUREUS; TIME-DEPENDENT; UNSATURATED ESTERS; VINYL SULFONES;

ENZYME INHIBITION; ESTERS; KETONES;

ENZYME ACTIVITY;

COENZYME A; CYSTEINE; ENZYME ACTIVATOR; ENZYME INHIBITOR; ESTER; KETONE; PHENYL GROUP; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE); SULFONE;

ADDITION REACTION; ARTICLE; BACTERIAL CELL; CHEMICAL REACTION; COENZYME; COMPETITION; CONJUGATE; ELECTROPHILICITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; SYNTHESIS; TIME;

COENZYME A; ENZYME INHIBITORS; KINETICS; NADH, NADPH OXIDOREDUCTASES; STAPHYLOCOCCUS AUREUS;

EID: 77956628119     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja106204m     Document Type: Article

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