Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Wang, Ning ^a   Zhu, Meifen ^a   Tsao, Sai Wah ^b   Man, Kwan ^b   Zhang, Zhangjin ^a   Feng, Yibin ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GELATINASE A; GELATINASE B; GENIPIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VIVO STUDY; INHIBITION KINETICS; LIVER CELL CARCINOMA; METASTASIS INHIBITION; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR VOLUME; UPREGULATION; WEIGHT REDUCTION; ZYMOGRAPHY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CHOLAGOGUES AND CHOLERETICS; DOWN-REGULATION; GENE SILENCING; HUMANS; IMIDAZOLES; IRIDOIDS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, SECOND PRIMARY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDINES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; UP-REGULATION;

ANIMALIA;

EID: 84867000366     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046318     Document Type: Article

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