메뉴 건너뛰기




Volumn 38, Issue 6, 2006, Pages 355-360

Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation

Author keywords

Fibrosis; Genipin; Myofibroblast; Subconjunctival fibroblast; Transforming growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; GENIPIN; GENIPOSIDE; HERBACEOUS AGENT; INCHIN KO TO; MESSENGER RNA; SIGNAL PEPTIDE; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 33750714819     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096231     Document Type: Article
Times cited : (36)

References (31)
  • 1
    • 0032820482 scopus 로고    scopus 로고
    • Transforming growth factor-β1, -β2, and - β3 in vivo: Effects on normal and mitomycin C-modulated conjunctival scarring
    • Cordeiro MF, Reichel MB, Gay JA, et al: Transforming growth factor-β1, -β2, and - β3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Invest Ophthalmol Vis Sci 1999;40:1975-1982.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1975-1982
    • Cordeiro, M.F.1    Reichel, M.B.2    Gay, J.A.3
  • 2
    • 0035022414 scopus 로고    scopus 로고
    • Accumulation of latent transforming growth factor-beta binding protein-1 and TGFβ1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts
    • Saika S, Yamanaka O, Baba Y, et al: Accumulation of latent transforming growth factor-beta binding protein-1 and TGFβ1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol 2001;239:234-241.
    • (2001) Graefes Arch Clin Exp Ophthalmol , vol.239 , pp. 234-241
    • Saika, S.1    Yamanaka, O.2    Baba, Y.3
  • 3
    • 0034146494 scopus 로고    scopus 로고
    • TGF-β1, -β2, and -β3 in vitro: Biphasic effects on Tenon's fibroblast contraction, proliferation, and migration
    • Cordeiro MF, Bhattacharya SS, Schultz GS, et al: TGF-β1, -β2, and -β3 in vitro: biphasic effects on Tenon's fibroblast contraction, proliferation, and migration. Invest Ophthalmol Vis Sci 2000;41:756-763.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 756-763
    • Cordeiro, M.F.1    Bhattacharya, S.S.2    Schultz, G.S.3
  • 4
    • 0142244187 scopus 로고    scopus 로고
    • Mediation of transforming growth factor-β1 stimulated matrix contraction by fibroblasts
    • Daniels JT, Schultz GS, Blalock TD, et al: Mediation of transforming growth factor-β1 stimulated matrix contraction by fibroblasts. Am J Pathol 2003;163:2043-2052.
    • (2003) Am J Pathol , vol.163 , pp. 2043-2052
    • Daniels, J.T.1    Schultz, G.S.2    Blalock, T.D.3
  • 5
    • 0037266027 scopus 로고    scopus 로고
    • Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome
    • Cordeiro MF, Mead A, Ali RR, et al: Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcome. Gene Ther 2003;10:59-71.
    • (2003) Gene Ther , vol.10 , pp. 59-71
    • Cordeiro, M.F.1    Mead, A.2    Ali, R.R.3
  • 6
    • 0030876857 scopus 로고    scopus 로고
    • Conjunctival fibrosis in ocular cicatricial pemphigoid - The role of cytokines
    • Elder MJ, Dart JK G, Lightman S: Conjunctival fibrosis in ocular cicatricial pemphigoid - the role of cytokines. Exp Eye Res 1997;65:165-176.
    • (1997) Exp Eye Res , vol.65 , pp. 165-176
    • Elder, M.J.1    Dart, J.K.G.2    Lightman, S.3
  • 7
    • 0025043971 scopus 로고
    • Transforming growth factor-β in human aqueous humor
    • Jampel HD, Roche N, Stark WJ, et al: Transforming growth factor-β in human aqueous humor. Curr Eye Res 1990;9:963-969.
    • (1990) Curr Eye Res , vol.9 , pp. 963-969
    • Jampel, H.D.1    Roche, N.2    Stark, W.J.3
  • 8
    • 0035078532 scopus 로고    scopus 로고
    • Modulation of wound healing after glaucoma surgery
    • Khaw PT, Chang L, Wong TT, et al: Modulation of wound healing after glaucoma surgery. Curr Opin Ophthalmol 2001;12:143-148.
    • (2001) Curr Opin Ophthalmol , vol.12 , pp. 143-148
    • Khaw, P.T.1    Chang, L.2    Wong, T.T.3
  • 9
    • 0036190919 scopus 로고    scopus 로고
    • Human antitransforming growth factor β2 monoclonal antibody - A new modulator of wound healing in trabeculectomy: A randomized placebo controlled clinical study
    • Siriwardena D, Khaw PT, King AJ, et al: Human antitransforming growth factor β2 monoclonal antibody - a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study. Ophthalmology 2002;109:427-431.
    • (2002) Ophthalmology , vol.109 , pp. 427-431
    • Siriwardena, D.1    Khaw, P.T.2    King, A.J.3
  • 10
    • 14544297836 scopus 로고    scopus 로고
    • RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis
    • Nakamura H, Siddiqui SS, Shen X, et al: RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis 2004;10:703-711.
    • (2004) Mol Vis , vol.10 , pp. 703-711
    • Nakamura, H.1    Siddiqui, S.S.2    Shen, X.3
  • 11
    • 11144358423 scopus 로고    scopus 로고
    • Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver
    • Shoda J, Miura T, Utsunomiya H, et al: Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology 2004;39:167-178.
    • (2004) Hepatology , vol.39 , pp. 167-178
    • Shoda, J.1    Miura, T.2    Utsunomiya, H.3
  • 12
    • 1242351826 scopus 로고    scopus 로고
    • A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to
    • Arai M, Yokosuka O, Fukai K, et al: A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to. Hepatol Res 2004;28:161-165.
    • (2004) Hepatol Res , vol.28 , pp. 161-165
    • Arai, M.1    Yokosuka, O.2    Fukai, K.3
  • 13
    • 0038578508 scopus 로고    scopus 로고
    • Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    • Sakaida I, Tsuchiya M, Kawaguchi K, et al: Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 2003;38:762-769.
    • (2003) J Hepatol , vol.38 , pp. 762-769
    • Sakaida, I.1    Tsuchiya, M.2    Kawaguchi, K.3
  • 14
    • 21644454094 scopus 로고    scopus 로고
    • Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora
    • Yim JS, Kim YS, Moon SK, et al: Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull 2004;27:1580-1583.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1580-1583
    • Yim, J.S.1    Kim, Y.S.2    Moon, S.K.3
  • 15
    • 4644243524 scopus 로고    scopus 로고
    • Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis
    • Inao M, Mochida S, Matsui A, et al: Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J Hepatol 2004;41:584-591.
    • (2004) J Hepatol , vol.41 , pp. 584-591
    • Inao, M.1    Mochida, S.2    Matsui, A.3
  • 16
    • 4444303261 scopus 로고    scopus 로고
    • Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats
    • Imanishi Y, Maeda N, Otogawa K, et al: Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats. J Hepatol 2004;41:242-250.
    • (2004) J Hepatol , vol.41 , pp. 242-250
    • Imanishi, Y.1    Maeda, N.2    Otogawa, K.3
  • 17
    • 0029834351 scopus 로고    scopus 로고
    • Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro
    • Saika S, Ooshima A, Yamanaka O, et al: Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human Tenon's capsule fibroblasts in vitro. Graefes Arch Clin Exp Ophthalmol 1996;234:S214-222.
    • (1996) Graefes Arch Clin Exp Ophthalmol , vol.234
    • Saika, S.1    Ooshima, A.2    Yamanaka, O.3
  • 18
    • 0037313142 scopus 로고    scopus 로고
    • Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGFβ1: Reversal of TGFβ-stimulated collagen production
    • Yamanaka O, Saika S, Okada Y, et al: Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGFβ1: reversal of TGFβ-stimulated collagen production. Graefes Arch Clin Exp Ophthalmol 2003;241: 116-124.
    • (2003) Graefes Arch Clin Exp Ophthalmol , vol.241 , pp. 116-124
    • Yamanaka, O.1    Saika, S.2    Okada, Y.3
  • 19
    • 3142606712 scopus 로고    scopus 로고
    • Comparison of alamar blue and MTT assays for high through-put screening
    • Hamid R, Rotshteyn Y, Rabadi L, et al: Comparison of alamar blue and MTT assays for high through-put screening. Toxicol In Vitro 2004;18:703-710.
    • (2004) Toxicol In Vitro , vol.18 , pp. 703-710
    • Hamid, R.1    Rotshteyn, Y.2    Rabadi, L.3
  • 20
    • 20944442872 scopus 로고    scopus 로고
    • Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-κB, in treatment of corneal alkali burns in mice
    • Saika S, Miyamoto T, Yamanaka O, et al: Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-κB, in treatment of corneal alkali burns in mice. Am J Pathol 2005;166:1393-1403.
    • (2005) Am J Pathol , vol.166 , pp. 1393-1403
    • Saika, S.1    Miyamoto, T.2    Yamanaka, O.3
  • 21
    • 20944448800 scopus 로고    scopus 로고
    • Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali
    • Saika S, Ikeda K, Yamanaka O, et al: Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 2005;166:1405-1418.
    • (2005) Am J Pathol , vol.166 , pp. 1405-1418
    • Saika, S.1    Ikeda, K.2    Yamanaka, O.3
  • 23
    • 4944260347 scopus 로고    scopus 로고
    • Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice
    • Saika S, Ikeda K, Yamanaka O, et al: Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest 2004;84:1259-1270.
    • (2004) Lab Invest , vol.84 , pp. 1259-1270
    • Saika, S.1    Ikeda, K.2    Yamanaka, O.3
  • 24
    • 1542289674 scopus 로고    scopus 로고
    • Smad3 signaling is required for epithelialmesenchymal transition of lens epithelium after injury
    • Saika S, Kono-Saika S, Ohnishi Y, et al: Smad3 signaling is required for epithelialmesenchymal transition of lens epithelium after injury. Am J Pathol 2004;164:651-663.
    • (2004) Am J Pathol , vol.164 , pp. 651-663
    • Saika, S.1    Kono-Saika, S.2    Ohnishi, Y.3
  • 25
    • 0035158501 scopus 로고    scopus 로고
    • Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ
    • Ishida I, Saika S, Ohnishi Y : Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ. Graefes Arch Clin Exp Ophthalmol 2001;239:770-777.
    • (2001) Graefes Arch Clin Exp Ophthalmol , vol.239 , pp. 770-777
    • Ishida, I.1    Saika, S.2    Ohnishi, Y.3
  • 26
    • 0029074765 scopus 로고
    • Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts
    • Saika S, Ooshima A, Hashizume N, et al: Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol 1995;233:347-353.
    • (1995) Graefes Arch Clin Exp Ophthalmol , vol.233 , pp. 347-353
    • Saika, S.1    Ooshima, A.2    Hashizume, N.3
  • 27
    • 2142646426 scopus 로고    scopus 로고
    • TGF-β signaling and the fibrotic response
    • Leask A, Abraham DJ : TGF-β signaling and the fibrotic response. FASEB J 2004;18:816-827.
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 28
    • 0034927240 scopus 로고    scopus 로고
    • Is Smad3 a major player in signal transduction pathways leading to fibrogenesis?
    • Roberts AB, Piek E, Bottinger EP, et al: Is Smad3 a major player in signal transduction pathways leading to fibrogenesis? Chest 2001;120:43S-47S.
    • (2001) Chest , vol.120
    • Roberts, A.B.1    Piek, E.2    Bottinger, E.P.3
  • 29
    • 0024559791 scopus 로고
    • Correlation of fibrosis and transforming growth factor-β type 2 levels in the eye
    • Connor TB Jr, Roberts AB, Sporn MB, et al: Correlation of fibrosis and transforming growth factor-β type 2 levels in the eye. J Clin Invest 1989;83:1661-1666.
    • (1989) J Clin Invest , vol.83 , pp. 1661-1666
    • Connor Jr., T.B.1    Roberts, A.B.2    Sporn, M.B.3
  • 30
    • 0035021939 scopus 로고    scopus 로고
    • Transforming growth factor β2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development
    • Picht G, Welge-Luessen U, Grehn F, et al: Transforming growth factor β2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch Clin Exp Ophthalmol 2001;239:199-207.
    • (2001) Graefes Arch Clin Exp Ophthalmol , vol.239 , pp. 199-207
    • Picht, G.1    Welge-Luessen, U.2    Grehn, F.3
  • 31
    • 0037437371 scopus 로고    scopus 로고
    • TGF-β1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins
    • Evans RA, Tian YC, Steadman R, et al: TGF-β1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res 2003;282:90-100.
    • (2003) Exp Cell Res , vol.282 , pp. 90-100
    • Evans, R.A.1    Tian, Y.C.2    Steadman, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.