Korean red ginseng suppresses metastasis of human hepatoma SK-Hep1 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen activator

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Ho, Yu Ling ^a   Li, Kun Cheng ^b   Chao, Wei ^b   Chang, Yuan Shiun ^b,c   Huang, Guan Jhong ^b  

^a HUNGKUANG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; GINSENG EXTRACT; UROKINASE;

ARTICLE; ASSAY; CANCER CELL; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; LIVER METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 84861052754     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/965846     Document Type: Article

References (23)

1. Suresh V., Sruthi V., Padmaja B., Asha V. V., In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb Journal of Ethnopharmacology 2011 134 3 872 877
2. Huang C. S., Fan Y. E., Lin C. Y., Hu M. L., Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1 Journal of Nutritional Biochemistry 2007 18 7 449 456
3. Chuang C. H., Hu M. L., L-carnosine inhibits metastasis of SK-Hep1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene, nm23-H1 Nutrition and Cancer 2008 60 4 526 533
4. Lai K. C., Huang A. N. C., Hsu S. C., Kuo C. L., Yang J. S., Wu S. H., Chung J. G., Benzyl Lsothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway Journal of Agricultural and Food Chemistry 2010 58 5 2935 2942
5. Sugita K., Recent advances in inhibitors of matrix metalloproteinases for cancer therapy IDrugs 1999 2 4 327 339 (Pubitemid 29166795)
6. Kim S. Y., Kim D. H., Han S. J., Hyun J. W., Kim H. S., Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells Biochemical Pharmacology 2007 74 11 1642 1651
7. Kim D. H., Metabolism of ginsenosides to bioactive compounds by intestinal microflora and its industrial application Journal of Ginseng Research 2009 33 3 165 176
8. Maeda-Yamamoto M., Suzuki N., Sawai Y., Miyase T., Sano M., Hashimoto-Ohta A., Isemura M., Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells Journal of Agricultural and Food Chemistry 2003 51 7 1858 1863
9. Huang G. J., Yang C. M., Chang Y. S., Amagaya S., Wang H. C., Hou W. C., Huang S. S., Hu M. L., Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways Journal of Agricultural and Food Chemistry 2010 58 17 9468 9475
10. Wong V. K. W., Cheung S. S. F., Li T., Jiang Z. H., Wang J. R., Dong H., Yi X. Q., Zhou H., Liu L., Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF- B signaling Journal of Cellular Biochemistry 2010 111 4 899 910
11. Yoon S. R., Lee G. D., Park J. H., Lee I. S., Kwon J. H., Ginsenoside composition and antiproliferative activities of explosively puffed ginseng (Panax ginseng C.A. Meyer) Journal of Food Science 2010 75 4 C378 C382
12. Kim H. S., Lee E. H., Ko S. R., Choi K. J., Park J. H., Im D. S., Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells Archives of Pharmacal Research 2004 27 4 429 435
13. Oh J. I., Chun K. H., Joo S. H., Oh Y. T., Lee S. K., Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells Cancer Letters 2005 230 2 228 238
14. Sato K., Mochizuki M., Saiki I., Yung Choon Yoo, Samukawa K. I., Azuma I., Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2 Biological and Pharmaceutical Bulletin 1994 17 5 635 639 (Pubitemid 24186106)
15. Yue P. Y. K., Wong D. Y. L., Wu P. K., Leung P. Y., Mak N. K., Yeung H. W., Liu L., Cai Z., Jiang Z. H., Fan T. P. D., Wong R. N. S., The angiosuppressive effects of 20(R)- ginsenoside Rg3 Biochemical Pharmacology 2006 72 4 437 445 (Pubitemid 44061747)
16. Kumar A., Kumar M., Park T. Y., Park M. H., Takemoto T., Terado T., Kitano M., Kimura H., Molecular mechanisms of ginsenoside Rp1-mediated growth arrest and apoptosis International Journal of Molecular Medicine 2009 24 3 381 386
17. Lee Y. S., Kim Y. H., Shin E. K., Kim D. H., Lim S. S., Lee J. Y., Kim J. K., Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions Journal of Ethnopharmacology 2010 131 1 56 62
18. Peng C. C., Chen K. C., Peng R. Y., Chyau C. C., Su C. H., Hsieh-Li H. M., Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells Journal of Ethnopharmacology 2007 109 1 93 103 (Pubitemid 44920191)
19. Lansky E. P., Newman R. A., Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer Journal of Ethnopharmacology 2007 109 2 177 206 (Pubitemid 44959707)
20. Fronza M., Heinzmann B., Hamburger M., Laufer S., Merfort I., Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts Journal of Ethnopharmacology 2009 126 3 463 467
21. Chernov A. V., Strongin A. Y., Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer Biomolecular Concepts 2011 2 2 135 147
22. Hwang E. S., Lee H. J., Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells Journal of Nutritional Biochemistry 2006 17 12 837 846 (Pubitemid 44767984)
23. Hapke S., Kessler H., De Prada N. A., Benge A., Schmitt M., Lengyel E., Reuning U., Integrin v 3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells Journal of Biological Chemistry 2001 276 28 26340 26348