Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide

Journal of Medicinal Chemistry

Volumn 55, Issue 16, 2012, Pages 7273-7284

  Reichstein, Alexandra ^a   Vortherms, Silke ^a   Bannwitz, Sven ^a   Tentrop, Jan ^a   Prinz, Helge ^a   Müller, Klaus ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 2 (3 ETHYL 1,2,4 OXADIAZOL 5 YL)NAPHTHO[2,3 B]FURAN 4,9 DIONE; BETA LAPACHONE; DITHRANOL; LACTATE DEHYDROGENASE; LAPACHOL; MENADIONE; NAPHTHO[2,3 B]FURAN 4,9 DIONE DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; KERATINOCYTE; MEMBRANE DAMAGE; REDUCTION; STRUCTURE ACTIVITY RELATION;

CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; DERMATOLOGIC AGENTS; DICUMAROL; FURANS; HUMANS; KERATINOCYTES; L-LACTATE DEHYDROGENASE; NAD(P)H DEHYDROGENASE (QUINONE); NADPH-FERRIHEMOPROTEIN REDUCTASE; NAPHTHOQUINONES; OXADIAZOLES; PSORIASIS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 84866952056     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3009597     Document Type: Article

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