Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b ]thiophene-4,9-dione, a quinone-based system

Journal of Medicinal Chemistry

Volumn 54, Issue 12, 2011, Pages 4077-4091

  Gomez Monterrey, Isabel ^a   Campiglia, Pietro ^b   Aquino, Claudio ^c   Bertamino, Alessia ^a   Granata, Ilaria ^b   Carotenuto, Alfonso ^a   Brancaccio, Diego ^a   Stiuso, Paola ^d   Scognamiglio, Ilaria ^d   Rusciano, M Rosaria ^a   Maione, Angela Serena ^a   Illario, Maddalena ^a   Grieco, Paolo ^a   Maresca, Bruno ^b   Novellino, Ettore ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (DIMETHYLAMINO) ETHYL] 3 [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] UREA; 1 [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 3 PROPYLUREA; 2 (N',N' DIETHYLAMINO) N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] ACETAMIDE HYDROCHLORIDE; 2 [2 (DIMETHYLAMINO) ETHYLAMINO] N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] ACETAMIDE DIHYDROCHLORIDE; 3 (3' BROMO) PROPANAMIDE 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO [2,3 B] NAPHTHO 4,9 DIONE AND 3 ACRYLAMIDO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO [2,3 B] NAPHTHO 4,9 DIONE; 3 (DIETHYLAMINO) N (4,9 DIOXO 4,9 DIHYDRONAPHTHO [2,3 B] THIOPHEN 3 YL) PROPANAMIDE; 3 (DIETHYLAMINO) N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] PROPANAMIDE; 3 [(BETA ALANYL)AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE TRIFLUOROACETATE; 3 [(GLYCYL) AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE TRIFLUOROACETATE; 3 [(L LYSYL) AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE BISTRIFLUOROACETATE; 3 [(L PHENYLYL) AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE TRIFLUOROACETATE; 3 [(L PROLYL) AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE TRIFLUOROACETATE; 3 [(LEVO ALANYL) AMINO] NAPHTHO [2,3 B] THIOPHENE 4,9 DIONE TRIFLUOROACETATE; 3 [2 (DIMETHYLAMINO) ETHYLAMINO] N (4,9 DIOXO 4,9 DIHYDRONAPHTHO [2,3 B] THIOPHEN 3 YL) PROPANAMIDE; 3 [2 (DIMETHYLAMINO) ETHYLAMINO] N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] PROPANAMIDE; ANTHRAQUINONE; DIHYDRONAPHTHO [2,3 B] THIOPHEN 4,9 DIONE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; GYRASE INHIBITOR; HEAT SHOCK PROTEIN; N (4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 3 MORPHOLINOPROPANAMIDE; N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 2 (N' MORPHOLINE) ACETAMIDE HYDROCHLORIDE; N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 2 HYDROXYACETAMIDE; N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 2 MERCAPTOACETAMIDE; N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 3 HYDROXYPROPIONAMIDE; N [4,9 DIOXO 4,9 DIHYDRONAPHTHO (2,3 B) THIOPHEN 3 YL] 3 MERCAPTOPROPANAMIDE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL VIABILITY; CELLULAR DISTRIBUTION; DNA BINDING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; FLOW CYTOMETRY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DOXORUBICIN; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HEAT-SHOCK PROTEINS; HUMANS; MYOCYTES, CARDIAC; NAPHTHALENES; NAPHTHOQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 79959486856     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200094h     Document Type: Article

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