Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones

Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2001, Pages 814-821

  Muller K ^a   Reindl, H ^b   Breu, K ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

10 ACETYL 1,8 DIHYDROXY 9(10H) ANTHRACENONE; ANTHRACENE DERIVATIVE; ANTHRONE; LEUKOTRIENE B4; N HYDROXY N METHYL 4 [2 (4,5 DIHYDROXY 10 OXO 9,10 DIHYDROANTHRACEN 9 YL) 2 OXOETHYL]PHENYLACETAMIDE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; ASSAY; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; MEMBRANE DAMAGE; NONHUMAN; OXIDATION; PSORIASIS; REDUCTION; STRUCTURE ACTIVITY RELATION;

ACETANILIDES; ANTHRACENES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL MEMBRANE; HUMANS; KERATINOCYTES; LEUKOTRIENE B4; OXIDATION-REDUCTION; PSORIASIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035282628     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001073w     Document Type: Article

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