-
1
-
-
0028303905
-
The complete sequence of the human CD79b (Ig beta/B29) gene: Identification of a conserved exon/ intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism
-
Hashimoto S, Chiorazzi N, Gregersen PK. The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/ intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. Immunogenetics. 1994;40:145-149.
-
(1994)
Immunogenetics
, vol.40
, pp. 145-149
-
-
Hashimoto, S.1
Chiorazzi, N.2
Gregersen, P.K.3
-
2
-
-
0027932623
-
Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene
-
Hashimoto S, Mohrenweiser HW, Gregersen PK, et al. Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene. Immunogenetics. 1994;40:287-295.
-
(1994)
Immunogenetics
, vol.40
, pp. 287-295
-
-
Hashimoto, S.1
Mohrenweiser, H.W.2
Gregersen, P.K.3
-
3
-
-
0026688237
-
The B cell antigen receptor complex: Association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors
-
Clark MR, Campbell KS, Kazlauskas A, et al. The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science. 1992;258:123-126.
-
(1992)
Science
, vol.258
, pp. 123-126
-
-
Clark, M.R.1
Campbell, K.S.2
Kazlauskas, A.3
-
5
-
-
0034717038
-
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor
-
Gaul BS, Harrison ML, Geahlen RL, et al. Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J Biol Chem. 2000;275:16174-16182.
-
(2000)
J Biol Chem
, vol.275
, pp. 16174-16182
-
-
Gaul, B.S.1
Harrison, M.L.2
Geahlen, R.L.3
-
6
-
-
0035956958
-
BLNK mediates Syk-dependent Btk activation
-
Baba Y, Hashimoto S,MatsushitaM, et al. BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci U S A. 2001;98:2582-2586.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 2582-2586
-
-
Baba, Y.1
Smatsushitam, H.2
-
7
-
-
0036205763
-
The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways
-
Kabak S, Skaggs BJ, Gold MR, et al. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002;22:2524-2535.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2524-2535
-
-
Kabak, S.1
Skaggs, B.J.2
Gold, M.R.3
-
8
-
-
61849183478
-
Bruton's tyrosine kinase (Btk): Function, regulation, and transformation with special emphasis on the PH domain
-
Mohamed AJ, Yu L, Backesjo CM, et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009;228:58-73.
-
(2009)
Immunol Rev
, vol.228
, pp. 58-73
-
-
Mohamed, A.J.1
Yu, L.2
Backesjo, C.M.3
-
9
-
-
2542443772
-
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC gamma 2 in B cells
-
Tomlinson MG, Woods DB, McMahon M, et al. A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC gamma 2 in B cells. BMC Immunol. 2001;2:4.
-
(2001)
BMC Immunol
, vol.2
, pp. 4
-
-
Tomlinson, M.G.1
Woods, D.B.2
McMahon, M.3
-
10
-
-
84858636448
-
The clinically active BTK inhibitor PCI-32765 targets B-cell receptorY and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
-
de Rooij MF, Kuil A, Geest CR, et al. The clinically active BTK inhibitor PCI-32765 targets B-cell receptorY and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood. 2012;119: 2590-2594.
-
(2012)
Blood
, vol.119
, pp. 2590-2594
-
-
De Rooij, M.F.1
Kuil, A.2
Geest, C.R.3
-
11
-
-
54349105076
-
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells
-
Halcomb KE, Musuka S, Gutierrez T, et al. Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells. Mol Immunol. 2008;46:233-241.
-
(2008)
Mol Immunol
, vol.46
, pp. 233-241
-
-
Halcomb, K.E.1
Musuka, S.2
Gutierrez, T.3
-
12
-
-
84859564599
-
Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
-
Lee KG, Xu S, Kang ZH, et al. Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci U S A. 2012;109:5791-5796.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 5791-5796
-
-
Lee, K.G.1
Xu, S.2
Zh, K.3
-
13
-
-
67649220610
-
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling
-
James RG, Biechele TL, Conrad WH, et al. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci Signal. 2009;2:ra25.
-
(2009)
Sci Signal
, vol.2
-
-
James, R.G.1
Biechele, T.L.2
Conrad, W.H.3
-
14
-
-
84860433198
-
Bruton tyrosine kinase (BTK) and its role in B-cell malignancy
-
Buggy JJ, Elias L. Bruton tyrosine kinase (BTK) and its role in B-cell malignancy. Int Rev Immunol. 2012;31:119-132.
-
(2012)
Int Rev Immunol
, vol.31
, pp. 119-132
-
-
Buggy, J.J.1
Elias, L.2
-
15
-
-
84864436773
-
Molecular pathways: Targeting the phosphoinositide 3-kinase (PI3-kinase) p110 delta in chronic lymphocytic leukemia
-
Johnson AJ, Herman SE. Molecular pathways: targeting the phosphoinositide 3-kinase (PI3-kinase) p110 delta in chronic lymphocytic leukemia. Clin Cancer Res. 2012;18:4013-4018.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4013-4018
-
-
Johnson, A.J.1
Herman, S.E.2
-
16
-
-
0029907533
-
The protein product of the protooncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgMYstimulated human B-lymphoma cells
-
Beckwith M, Jorgensen G, Longo DL. The protein product of the protooncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgMYstimulated human B-lymphoma cells. Blood. 1996;88:3502-3507.
-
(1996)
Blood
, vol.88
, pp. 3502-3507
-
-
Beckwith, M.1
Jorgensen, G.2
Longo, D.L.3
-
17
-
-
0037079737
-
Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement
-
Inabe K, Kurosaki T. Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement. Blood. 2002;99:584-589.
-
(2002)
Blood
, vol.99
, pp. 584-589
-
-
Inabe, K.1
Kurosaki, T.2
-
18
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
19
-
-
0037039320
-
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes
-
Fruman DA, Ferl GZ, An SS, et al. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A. 2002;99:359-364.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 359-364
-
-
Fruman, D.A.1
Ferl, G.Z.2
An, S.S.3
-
20
-
-
33846621025
-
Antigen receptor signalling: A distinctive role for the p110delta isoform of PI3K
-
Okkenhaug K, Ali K, Vanhaesebroeck B. Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol. 2007;28:80-87.
-
(2007)
Trends Immunol
, vol.28
, pp. 80-87
-
-
Okkenhaug, K.1
Ali, K.2
Vanhaesebroeck, B.3
-
21
-
-
84857844598
-
PI3Kdelta inhibitors in cancer: Rationale and serendipity merge in the clinic
-
Fruman DA, Rommel C. PI3Kdelta inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov. 2011;1:562-572.
-
(2011)
Cancer Discov
, vol.1
, pp. 562-572
-
-
Fruman, D.A.1
Rommel, C.2
-
22
-
-
34547930555
-
The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia
-
Kipps TJ. The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia. Best Pract Res Clin Haematol. 2007;20:415-424.
-
(2007)
Best Pract Res Clin Haematol
, vol.20
, pp. 415-424
-
-
Kipps, T.J.1
-
23
-
-
0033548446
-
The SH2 domain-containing inositol 5¶-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling
-
Gupta N, Scharenberg AM, Fruman DA, et al. The SH2 domain-containing inositol 5¶-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling. J Biol Chem. 1999;274:7489-7494.
-
(1999)
J Biol Chem
, vol.274
, pp. 7489-7494
-
-
Gupta, N.1
Scharenberg, A.M.2
Fruman, D.A.3
-
24
-
-
0027499537
-
Receptor editing: An approach by autoreactive B cells to escape tolerance
-
Gay D, Saunders T, Camper S, et al. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med. 1993;177: 999-1008.
-
(1993)
J Exp Med
, vol.177
, pp. 999-1008
-
-
Gay, D.1
Saunders, T.2
Camper, S.3
-
25
-
-
46749099871
-
Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection
-
Ghia EM, Jain S, Widhopf GF 2nd, et al. Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection. Blood. 2008;111:5101-5108.
-
(2008)
Blood
, vol.111
, pp. 5101-5108
-
-
Ghia, E.M.1
Jain, S.2
Widhopf, I.I.G.F.3
-
26
-
-
78049494232
-
BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling
-
Rowland SL, Leahy KF, Halverson R, et al. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol. 2010;185:4570-4581.
-
(2011)
J Immunol
, vol.185
, pp. 4570-4581
-
-
Rowland, S.L.1
Leahy, K.F.2
Halverson, R.3
-
28
-
-
0025355883
-
Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes
-
Reichman-Fried M, Hardy RR, Bosma MJ. Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc Natl Acad Sci U S A. 1990;87:2730-2734.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 2730-2734
-
-
Reichman-Fried, M.1
Hardy, R.R.2
Bosma, M.J.3
-
29
-
-
0028347698
-
Influence of immunoglobulin heavyand light-chain expression on B-cell differentiation
-
Young F, Ardman B, Shinkai Y, et al. Influence of immunoglobulin heavyand light-chain expression on B-cell differentiation. Genes Dev. 1994;8: 1043-1057.
-
(1994)
Genes Dev
, vol.8
, pp. 1043-1057
-
-
Young, F.1
Ardman, B.2
Shinkai, Y.3
-
30
-
-
33645051417
-
Infection-associated lymphomas derived from marginal zone B cells: A model of antigen-driven lymphoproliferation
-
Suarez F, Lortholary O, Hermine O, et al. Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood. 2006;107:3034-3044.
-
(2006)
Blood
, vol.107
, pp. 3034-3044
-
-
Suarez, F.1
Lortholary, O.2
Hermine, O.3
-
31
-
-
84857800931
-
Long-termclinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: A multicentre cohort follow-up study of 420 patients in Japan
-
Nakamura S, Sugiyama T, Matsumoto T, et al. Long-termclinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan. Gut. 2012;61:507-513.
-
(2012)
Gut
, vol.61
, pp. 507-513
-
-
Nakamura, S.1
Sugiyama, T.2
Matsumoto, T.3
-
32
-
-
77954567847
-
B-cell receptor signaling and CD40 ligandYindependent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis
-
Craig VJ, Cogliatti SB, Arnold I, et al. B-cell receptor signaling and CD40 ligandYindependent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis. Leukemia. 2010;24:1186-1196.
-
(2011)
Leukemia
, vol.24
, pp. 1186-1196
-
-
Craig, V.J.1
Cogliatti, S.B.2
Arnold, I.3
-
33
-
-
84859450196
-
BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas
-
Yan Q, Huang Y,Watkins AJ, et al. BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas. Haematologica. 2012;97:595-598.
-
(2012)
Haematologica
, vol.97
, pp. 595-598
-
-
Yan, Q.1
Huang Ywatkins, A.J.2
-
34
-
-
80054853285
-
B-cell receptor signaling in chronic lymphocytic leukemia
-
Stevenson FK, Krysov S, Davies AJ, et al. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118:4313-4320.
-
(2011)
Blood
, vol.118
, pp. 4313-4320
-
-
Stevenson, F.K.1
Krysov, S.2
Davies, A.J.3
-
35
-
-
4344704897
-
Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
-
Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200:519-525.
-
(2004)
J Exp Med
, vol.200
, pp. 519-525
-
-
Messmer, B.T.1
Albesiano, E.2
Efremov, D.G.3
-
36
-
-
4944244255
-
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
-
Widhopf GFn, Rassenti LZ, Toy TL, et al. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood. 2004;104:2499-2504.
-
(2004)
Blood
, vol.104
, pp. 2499-2504
-
-
Gfn, W.1
Rassenti, L.Z.2
Toy, T.L.3
-
37
-
-
33846108722
-
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
-
Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109:259-270.
-
(2007)
Blood
, vol.109
, pp. 259-270
-
-
Stamatopoulos, K.1
Belessi, C.2
Moreno, C.3
-
38
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling NF-kappaB activation and tumor proliferation in chronic lymphocytic leukemia
-
Herishanu Y, Perez-Galan P, Liu D, et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood. 2011;117: 563-574.
-
(2011)
Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.1
Perez-Galan, P.2
Liu, D.3
-
39
-
-
47249152803
-
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: A molecular signature of anergy
-
Muzio M, Apollonio B, Scielzo C, et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 2008;112:188-195.
-
(2008)
Blood
, vol.112
, pp. 188-195
-
-
Muzio, M.1
Apollonio, B.2
Scielzo, C.3
-
40
-
-
20444389401
-
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
-
Petlickovski A, Laurenti L, Li X, et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood. 2005;105:4820-4827.
-
(2005)
Blood
, vol.105
, pp. 4820-4827
-
-
Petlickovski, A.1
Laurenti, L.2
Li, X.3
-
41
-
-
50949128066
-
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells
-
Guarini A, Chiaretti S, Tavolaro S, et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells. Blood. 2008;112:782-792.
-
(2008)
Blood
, vol.112
, pp. 782-792
-
-
Guarini, A.1
Chiaretti, S.2
Tavolaro, S.3
-
42
-
-
41949140313
-
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia
-
Chen L, Huynh L, Apgar J, et al. ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood. 2008;111:2685-2692.
-
(2008)
Blood
, vol.111
, pp. 2685-2692
-
-
Chen, L.1
Huynh, L.2
Apgar, J.3
-
43
-
-
52649143664
-
Relative value of ZAP-70 CD38 and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
-
Rassenti LZ, Jain S, Keating MJ, et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood. 2008;112:1923-1930.
-
(2008)
Blood
, vol.112
, pp. 1923-1930
-
-
Rassenti, L.Z.1
Jain, S.2
Keating, M.J.3
-
44
-
-
79960917689
-
Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling
-
Pighi C, Gu TL, Dalai I, et al. Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr). 2011;34:141-153.
-
(2011)
Cell Oncol (Dordr)
, vol.34
, pp. 141-153
-
-
Pighi, C.1
Gu, T.L.2
Dalai, I.3
-
45
-
-
77956404705
-
Proteomic analysis of B-cell malignancies
-
Boyd RS, DyerMJ, Cain K. Proteomic analysis of B-cell malignancies. J Proteomics. 2010;73:1804-1822.
-
(2011)
J Proteomics
, vol.73
, pp. 1804-1822
-
-
Boyd, R.S.1
Dyer, M.J.2
Cain, K.3
-
46
-
-
79958811060
-
Molecular signatures in the diagnosis and management of diffuse large B-cell lymphoma
-
Sweetenham JW. Molecular signatures in the diagnosis and management of diffuse large B-cell lymphoma. Curr Opin Hematol. 2011;18:288-292.
-
(2011)
Curr Opin Hematol
, vol.18
, pp. 288-292
-
-
Sweetenham, J.W.1
-
47
-
-
41149136296
-
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
-
Lenz G, Davis RE, Ngo VN, et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008;319:1676-1679.
-
(2008)
Science
, vol.319
, pp. 1676-1679
-
-
Lenz, G.1
Davis, R.E.2
Ngo, V.N.3
-
48
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
-
Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463:88-92.
-
(2011)
Nature
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
-
49
-
-
78651066552
-
Critical role of PI3Ksignaling for NF-kappaBYdependent survival in a subset of activated B-cellYlike diffuse large B-cell lymphoma cells
-
Kloo B,NagelD, PfeiferM, et al.Critical role of PI3Ksignaling for NF-kappaBYdependent survival in a subset of activated B-cellYlike diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A. 2011;108:272-277.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 272-277
-
-
Kloo, B.1
Nagel, D.2
Pfeifer, M.3
-
50
-
-
73949099017
-
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase PTPROt
-
Juszczynski P, Chen L, O'Donnell E, et al. BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt. Blood. 2009;114:5315-5321.
-
(2009)
Blood
, vol.114
, pp. 5315-5321
-
-
Juszczynski, P.1
Chen, L.2
O'Donnell, E.3
-
51
-
-
41349110211
-
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
-
Chen L, Monti S, Juszczynski P, et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood. 2008;111:2230-2237.
-
(2008)
Blood
, vol.111
, pp. 2230-2237
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
-
52
-
-
84865082196
-
Novel targets agents and the need to refine clinical end points in chronic lymphocytic leukemia
-
Cheson BD, Byrd JC, Rai KR, et al. Novel targets agents and the need to refine clinical end points in chronic lymphocytic leukemia. J Clin Oncol. 2012;10;30:2820-2822.
-
(2012)
J Clin Oncol
, vol.10
, Issue.30
, pp. 2820-2822
-
-
Cheson, B.D.1
Byrd, J.C.2
Rai, K.R.3
-
53
-
-
78649759107
-
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
-
Suljagic M, Longo PG, Bennardo S, et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood. 2010;116:4894-4905.
-
(2010)
Blood
, vol.116
, pp. 4894-4905
-
-
Suljagic, M.1
Longo, P.G.2
Bennardo, S.3
-
54
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. 2010;115: 2578-2585.
-
(2011)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
55
-
-
78650294662
-
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
-
Genovese MC, Kavanaugh A, Weinblatt ME, et al. An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum. 2011;63:337-345.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 337-345
-
-
Genovese, M.C.1
Kavanaugh, A.2
Weinblatt, M.E.3
-
56
-
-
84863781222
-
Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration
-
Hoellenriegel J, Coffey GP, Sinha U, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012.26:1576-1583.
-
(2012)
Leukemia
, vol.26
, pp. 1576-1583
-
-
Hoellenriegel, J.1
Coffey, G.P.2
Sinha, U.3
-
57
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117:591-594.
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
Meadows, S.A.2
Herman, S.E.3
-
58
-
-
77957201023
-
Phosphatidylinositol 3-kinasedelta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL,Wagner AJ, et al. Phosphatidylinositol 3-kinasedelta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078-2088.
-
(2011)
Blood
, vol.116
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
59
-
-
80053345977
-
The phosphoinositide 3¶-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
Hoellenriegel J, Meadows SA, Sivina M, et al. The phosphoinositide 3¶-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 2011;118:3603-3612.
-
(2011)
Blood
, vol.118
, pp. 3603-3612
-
-
Hoellenriegel, J.1
Meadows, S.A.2
Sivina, M.3
-
60
-
-
77957203544
-
Interim results from a phase i study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110d isoform, in patients with relapsed or refractory hematologic malignancies
-
Abstract 3032
-
Furman RR, Byrd JC, Flinn IW, et al. Interim results from a phase I study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110d isoform, in patients with relapsed or refractory hematologic malignancies. J Clin Oncol. 2010;28. Abstract 3032.
-
(2011)
J Clin Oncol
, vol.28
-
-
Furman, R.R.1
Byrd, J.C.2
Flinn, I.W.3
-
61
-
-
84866924543
-
Significant clinical activity of CAL-101, an isoform-selective inhibitor of phosphatidylinositol-3 kinase p110delta in patients with relapsed or refractory indolent and mantle cell lymphoma [abstract]
-
Abstract 350
-
Kahl BS, Byrd JC, Flinn IW. Significant clinical activity of CAL-101, an isoform-selective inhibitor of phosphatidylinositol-3 kinase p110delta in patients with relapsed or refractory indolent and mantle cell lymphoma [abstract]. Ann Oncol. 2011;22. Abstract 350.
-
(2011)
Ann Oncol
, vol.22
-
-
Kahl, B.S.1
Byrd, J.C.2
Flinn, I.W.3
-
62
-
-
80053079880
-
Phase i study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia
-
Abstract 6631
-
Coutre SE, Byrd JC, Brown JR, et al. Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in patients with previously treated chronic lymphocytic leukemia. J Clin Oncol. 2011;29. Abstract 6631.
-
(2011)
J Clin Oncol
, vol.29
-
-
Coutre, S.E.1
Byrd, J.C.2
Brown, J.R.3
-
63
-
-
84861344593
-
A phase 1 study of the selective phosphatidylinositol 3-kinase delta inhibitor CAL-101 (GS-1101) in combination with rituximab andor bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia
-
Sharman J, de Vos S, Leonard JP, et al. A phase 1 study of the selective phosphatidylinositol 3-kinase delta inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia. ASH Annu Meeting Abstr. 2011;118:1787.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 1787
-
-
Sharman, J.1
De Vos, S.2
Leonard, J.P.3
-
64
-
-
78951479819
-
A phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in combination with rituximab and/or bendamustine in patients with relapsed or refractory B-cell malignancies
-
Flinn IW, Schreeder MT, Wagner-Johnston ND, et al. A phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase P110d, in combination with rituximab and/or bendamustine in patients with relapsed or refractory B-cell malignancies. ASH Annu Meeting Abstr. 2010;116:2832.
-
(2011)
ASH Annu Meeting Abstr
, vol.116
, pp. 2832
-
-
Flinn, I.W.1
Schreeder, M.T.2
Wagner-Johnston, N.D.3
-
65
-
-
84876346683
-
A phase I/II study of the selective phosphatidylinositol 3-kinase delta inhibitor GS-1101 (CAL-101) with ofatumumab in patients with previously treated chronic lymphocytic leukemia
-
Abstract 6518
-
Furman RR, Barrientos JC, Sharman J, et al. A phase I/II study of the selective phosphatidylinositol 3-kinase delta inhibitor GS-1101 (CAL-101) with ofatumumab in patients with previously treated chronic lymphocytic leukemia. J Clin Oncol. 2012;30. Abstract 6518.
-
(2012)
J Clin Oncol
, vol.30
-
-
Furman, R.R.1
Barrientos, J.C.2
Sharman, J.3
-
66
-
-
77955625479
-
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
-
Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010;107:13075-13080.
-
(2011)
Proc Natl Acad Sci U S A
, vol.107
, pp. 13075-13080
-
-
Honigberg, L.A.1
Smith, A.M.2
Sirisawad, M.3
-
67
-
-
78649797979
-
Effect of Btk Inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase i study
-
Abstract 8012
-
Advani R, Sharman J, Smith SM, et al. Effect of Btk Inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: evidence of antitumor activity from a phase I study. J Clin Oncol. 2010;28:15s. Abstract 8012.
-
(2011)
J Clin Oncol
, vol.28
-
-
Advani, R.1
Sharman, J.2
Smith, S.M.3
-
68
-
-
84863011553
-
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
-
Ponader S, Chen SS, Buggy JJ, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012;119:1182-1189.
-
(2012)
Blood
, vol.119
, pp. 1182-1189
-
-
Ponader, S.1
Chen, S.S.2
Buggy, J.J.3
-
69
-
-
84861345119
-
The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL/SLL): Follow-up of a phase Ib/II study
-
O'Brien S, Burger JA, Blum KA, et al. The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL/SLL): follow-up of a phase Ib/II study. ASH Annu Meeting Abstr. 2011;118:983.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 983
-
-
O'Brien, S.1
Burger, J.A.2
Blum, K.A.3
-
70
-
-
84860430028
-
The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): Preliminary results of a phase II trial
-
Wang L, Marin P, Blum KA, et al. The Bruton's tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): preliminary results of a phase II trial. ASH Annu Meeting Abstr. 2011;118:442.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 442
-
-
Wang, L.1
Marin, P.2
Blum, K.A.3
-
71
-
-
84867840656
-
The Bruton's tyrosine kinase inhibitor PCI-32765 in treatment-naive chronic lymphocytic leukemia patients: Interim results of a phase Ib/II study
-
Abstract 6507
-
Byrd JC, Furman RR, Coutre SE, et al. The Bruton's tyrosine kinase inhibitor PCI-32765 in treatment-naive chronic lymphocytic leukemia patients: interim results of a phase Ib/II study. J Clin Oncol. 2012;30. Abstract 6507.
-
(2012)
J Clin Oncol
, vol.30
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
-
72
-
-
84863329356
-
Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor, PCI-32765, in mantle cell lymphoma patients
-
Chang B, Francesco M, Magadala P, et al. Egress of CD19+CD5+ cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor, PCI-32765, in mantle cell lymphoma patients. ASH Annu Meeting Abstr. 2011;118:954.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 954
-
-
Chang, B.1
Francesco, M.2
Magadala, P.3
-
73
-
-
84867853067
-
A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and related diseases
-
Abstract 6508
-
Jaglowski S, Jones JA, Flynn J, et al. A phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and related diseases. J Clin Oncol. 2012;30. Abstract 6508.
-
(2012)
J Clin Oncol
, vol.30
-
-
Jaglowski, S.1
Jones, J.A.2
Flynn, J.3
-
74
-
-
84860478464
-
The Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 modulates chronic active BCR signaling and induces tumor regression in relapsed/refractory ABC DLBCL
-
Staudt LM, Dunleavy K, Buggy JJ, et al. The Bruton's tyrosine kinase (Btk) inhibitor PCI-32765 modulates chronic active BCR signaling and induces tumor regression in relapsed/refractory ABC DLBCL. ASH Annu Meeting Abstr. 2011;118:2716.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 2716
-
-
Staudt, L.M.1
Dunleavy, K.2
Buggy, J.J.3
-
75
-
-
84860470820
-
Clinical development of AVL-292; A potent, selective covalent Btk inhibitor for the treatment of B cell malignancies
-
Evans E, Tester R, Aslanian S, et al. Clinical development of AVL-292; a potent, selective covalent Btk inhibitor for the treatment of B cell malignancies. ASH Annu Meeting Abstr. 2011;118:3485.
-
(2011)
ASH Annu Meeting Abstr
, vol.118
, pp. 3485
-
-
Evans, E.1
Tester, R.2
Aslanian, S.3
-
76
-
-
84867889132
-
Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase, in chronic lymphocytic leukemia and BYnon-Hodgkin lymphoma
-
Abstract 8032
-
Brown JR, Sharman J, Harb WA, et al. Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase, in chronic lymphocytic leukemia and BYnon-Hodgkin lymphoma. J Clin Oncol. 2012;30. Abstract 8032.
-
(2012)
J Clin Oncol
, vol.30
-
-
Brown, J.R.1
Sharman, J.2
Harb, W.A.3
-
77
-
-
0028246272
-
Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes
-
Tordai A, Franklin RA, Patel H, et al. Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes. J Biol Chem. 1994;269:7538-7543.
-
(1994)
J Biol Chem
, vol.269
, pp. 7538-7543
-
-
Tordai, A.1
Franklin, R.A.2
Patel, H.3
-
78
-
-
78751684268
-
Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib
-
Messmer D, Fecteau JF, O'Hayre M, et al. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011;117: 882-889.
-
(2011)
Blood
, vol.117
, pp. 882-889
-
-
Messmer, D.1
Fecteau, J.F.2
O'Hayre, M.3
-
79
-
-
84857007592
-
Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1)
-
Fecteau JF, Bharati IS, O'Hayre M, et al. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Mol Med. 2012; 18:19-28.
-
(2012)
Mol Med
, vol.18
, pp. 19-28
-
-
Fecteau, J.F.1
Bharati, I.S.2
O'Hayre, M.3
-
80
-
-
77955648969
-
Pathway-based identification of biomarkers for targeted therapeutics: Personalized oncology with PI3K pathway inhibitors
-
Andersen JN, Sathyanarayanan S, Di Bacco A, et al. Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med. 2010;2:43ra55.
-
(2011)
Sci Transl Med
, vol.2
-
-
Andersen, J.N.1
Sathyanarayanan, S.2
Di Bacco, A.3
-
81
-
-
84862152044
-
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma
-
Yang Y, Shaffer AL, Emre NC, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012; 21:723-737.
-
(2012)
Cancer Cell
, vol.21
, pp. 723-737
-
-
Yang, Y.1
Shaffer, A.L.2
Emre, N.C.3
|