Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 20, 2012, Pages 6073-6079

  Zhang, Shuting ^a   Cheng, Kui ^a   Wang, Xiaohui ^a   Yin, Hang ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Anti inflammation; Arylidene malonate; NF B; Toll like receptor 4

Indexed keywords

2 (2 FLUOROBENZYLIDENE)MALONIC ACID; 2 (2 METHOXYBENZYLIDENE)MALONIC ACID; 2 (3 NITROBENZYLIDENE)MALONIC ACID; 2 BENZYLIDENE MALONIC ACID; CURCUMIN; DIMETHYL 2 (2 CHLOROBENZYLIDENE)MALONATE; DIMETHYL 2 (2 CYCLOHEXYLMETHYLENE)MALONATE; DIMETHYL 2 (2 FLUOROBENZYLIDENE)MALONATE; DIMETHYL 2 (2 METHOXYBENZYLIDENE)MALONATE; DIMETHYL 2 (2 NITROBENZYL)MALONATE; DIMETHYL 2 (2 NITROBENZYLIDENE)MALONATE; DIMETHYL 2 (2.4 DIFLUOROBENZYLIDENE)MALONATE; DIMETHYL 2 (2.4 DIMETHOXYBENZYLIDENE)MALONATE; DIMETHYL 2 (3 FLUOROBENZYLIDENE)MALONATE; DIMETHYL 2 (3 METHOXYBENZYLIDENE)MALONATE; DIMETHYL 2 (3 NITROBENZYLIDENE)MALONATE; DIMETHYL 2 (4 CHLOROBENZYLIDENE)MALONATE; DIMETHYL 2 (4 FLUOROBENZYLIDENE)MALONATE; DIMETHYL 2 (4 METHOXYBENZYLIDENE)MALONATE; DIMETHYL 2 (4 NITROBENZYLIDENE)MALONATE; DIMETHYL 2 [4 (DIMETHYLAMINO)BENZYLIDENE]MALONATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MALONIC ACID DERIVATIVE; METHYL 3 (2 NITROPHENYL)ACRYLATE; NITRIC OXIDE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZYLIDENE COMPOUNDS; BINDING SITES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MALONATES; MICE; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; NITRIC OXIDE; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 84866919941     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.022     Document Type: Article

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