A review on phytochemical, ethnomedical and pharmacological studies on genus Sophora, Fabaceae

Revista Brasileira de Farmacognosia

Volumn 22, Issue 5, 2012, Pages 1145-1154

  Krishna, Panthati Murali ^a   Rao, K N V ^a   Sandhya, S ^a   Banji, David ^a  

^a Nalanda College of Pharmacy   (India)

Author keywords

Flavonoids; Matrine and oxymatrine alkaloids; Sophora; Sophoramine; Sophoroflavonone G

Indexed keywords

5 METHYLSOPHORAFLAVANONE B; ALKALOID; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTIVIRUS AGENT; DAIDZEIN; DERMATOLOGICAL AGENT; FATTY ACID DERIVATIVE; FLAVONOID; FORMONONETIN; GERALDOL; ISOSCUTELLAREIN; KURARINOL; MAACKIAIN; MATRINE; OROBOL; OXYMATRINE; PLANT MEDICINAL PRODUCT; POLYSACCHARIDE; PSEUDOBAPTIGENIN; PTEROCARPIN; QUINOLIZIDINE DERIVATIVE; RUTOSIDE; SISSOTRIN; SOPHOCARPINE; SOPHORA FLAVESCENS EXTRACT; TRIFOLIRHIZIN; UMBELLIFERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARIABILLIN;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPYRETIC ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; CHINESE MEDICINE; CLINICAL TRIAL (TOPIC); COLITIS; ECZEMA; ETHNOPHARMACOLOGY; FABACEAE; HAIR GROWTH; HUMAN; NONHUMAN; PHYTOCHEMISTRY; PLANT ROOT; PSORIASIS; REVIEW; SARCOMA 180; SOPHORA; SOPHORA FLAVESCENS; SOPHORA JAPONICA; TRADITIONAL MEDICINE;

EID: 84866897920     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2012005000043     Document Type: Review

References (101)

1. Ahn DK 1998. Illustrated Book of Korean Medicinal Herbs. Kyo-Hak Publisher: Seoul, p.199.
2. Rahman AU, Choudhary MI, Parvez K, Ahmed A, Akhtar F, Nur-E-Alam M, Hassan NM 2000. Quinolizidine alkaloids from Sophora alopecuroides. J Nat Prod 63: 190-192.
3. Bach MK, Brashler JR 1975. Inhibition of IgE and compound 48/80-induced histamine release by lectins. Immunology 29: 371-386.
4. Bai SZ, He JH, Yang ZQ, Rao EC 1982. Studies on alkaloidal components of KuShen (Sophora flavescens Aiton) II. Isolation of oxymatrine and other alkaloids. Chinese Traditional and Herbal Drugs 13: 8-9.
5. Bassem SM, Fayad W, Khaled M, Hallouty SM, Manawaty M, Olofsson MH, Linder S 2010. Antiproliferation effects of Sophopra japonica. Ind J Exp Biol 48: 258-264.
6. Bourbon AI, Pinheiro AC, Ribeiro C, Miranda C, Maia JM, Teixeira JA, Vicente AA 2010. Characterization of galactomannans extracted from seeds of Gleditsia triacanthos and Sophora japonica through shear and extensional rheology: Comparison with guar gum and locust bean gum. Food Hydrocolloid 24: 184-192.
7. Cai YZ, Luo Q, Sun M, Corke H 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 74: 2157-2184.
8. Cai YZ, Sun M, Xing J, Luo Q, Corke H 2006. Stuctureradical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci 75: 2872-2888.
9. Chen Y, Jiang PC 1994. A brief survey on studies of the Sophora subprostrata. Guangxi Medicine 16: 499-501.
10. Cheng H, Xia B, Zhang L, Zhou F, Zhang YX, Ye M, Hu ZG, Li J, Wang ZL, Li C, Guo QS 2006. Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Pharmacol Res 53: 202-208.
11. Ding PL, Chen DF 2006. Isoprenylated flavonoids from the roots and rhizomes of Sophora tonkinensis. Helv Chim Acta 89: 103-110.
12. Ding PL, Chen DF 2007. Three cyclized isoprenylated flavonoids from the roots and rhizomes of Sophora tonkinensis. Helv Chim Acta 90: 2236-2244.
13. Ding PL, Liao ZX, Huang H, Zhou P, Chena DF 2006. (+)-12a-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens. Bio org Med Chem Lett 16: 1231-1235.
14. Dong Q, Ding SW, Fang JN 1998. Studies on xyloglucan from Sophora subprostrata. Chinese J Biochem Mol Biol 14: 746-750.
15. Dong Q, Ding SW, Yang X, Fang JN 1999. Structural features of a heteroxylan from Sophora subprostrata roots. Phytochemistry 50: 81-84.
16. Dong Q, Yao J, Fang JN 2003. Structural characterization of the water-extractable polysaccharides from Sophora subprostrata roots. Carbohyd Polym 54: 13-19.
17. Gao KP 2006. Zhongguo shiliao bencao. Beijing, China: Chemical Industry Press. p. 400.
18. Grishkovets VI, Gorbacheva LA 1995. Triterpene glycosides of Sophora japonica seeds. Chem Nat Comp 31: 596-599.
19. Guan Y, Ma CH, Huang XY, Li ZX, Huang CG 2009. Components of Sophora alopecuroides seeds. Chem Nat Comp 45: 545-546.
20. Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T 2005. Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine-and (+)-allomatrineinduced antinociceptive effects. Biol Pharm Bull 28: 845-848.
21. Hu ZL, Zhang JP, Qian DH, Lin W, Xie WF, Zhang XR, Chen WZ 1996a. Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and-6 from peritoneal macrophages in vitro. Zhongguo Yao Li Xue Bao 17: 259-261.
22. Hu ZL, Zhang JP, Wan MB, Yu XB, Lin W, Qian DH 1996b. Effect of matrine on mouse hepatitis and tumour necrosis factor production induced by Propionibacterium acnes/ lipopolysaccharides. Zhongguo Yao Li Xue Bao 31: 662-665.
23. Hu ZL, Zhang JP, Yu XB, Lin W, Qian DH, Wan MB 1996c. Effect of matrine on lipopolysaccharides/Dgalactosamine-induced hepatitis and tumour necrosis factor release from macrophages in vitro. Zhongguo Yao Li Xue Bao 17: 351-353.
24. Hwang EM, Ryu YB, Kim HY, Kim DG, Hong SG, Lee JH, Long MJC, Jeong SH, Park JY, Park KH 2008. BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem 16: 6669-6674.
25. Iinuma M, Ohyama M, Kawasaka Y, Tanaka Y 1995a. Flavonoid compounds in roots of Sophora tetraptera. Phytochemistry 39: 667-672.
26. Iinuma M, Ohyama M, Tanaka T 1995b. Flavonoids in roots of Sophora prostrate. Phytochem 38: 539-543.
27. Iinuma M, Ohyama M, Tanaka T 1995c. Six Flavonostilbenes and a flavanone in roots of Sophora alopecuroides. Phytochemistry 38: 519-525.
28. Iinuma M, Ohyama M, Tanaka T. Shirataki Y, Burandt CL 1995d. Isoflavonoids in roots of Sophora secundiflora, Phytochemistry 39: 907-910.
29. Iinuma M, Ohyama M, Tanaka T, Mizuno M, Hong SK 1991. An isoflavanone from roots of Echinosophora koreensis. Phytochemistry 30: 3153-3154.
30. Iinuma M, Ohyama M, Tanaka T, Mizuno M, Hong SK 1992a. Three 2',4',6'-trioxy-genated flavanones in roots of Echinosophora koreensis. Phytochemistry 31: 665-669.
31. Iinuma M, Ohyama M, Tanaka T, Mizuno M, Hong SK 1992b. Three 2',4',6'-trioxy-genated flavanones in roots of Echinosophora koreensis. Phytochem 31 (8): 2855-2858.
32. Iinuma M, Ohyama M, Tanaka T, Mizuno M, Hong SK 1993. Five flavonoid compounds from Echinosophora koreensis. Photochemistry 33: 1241-1245.
33. Ishida H, Umino T, Tsuji K, Kosuge T 1989. Studies on the anti hemorrhagic substances in herbs classified as hemostatics in Chinese medicine X. On hemostatic activities of the parched herbs for hemostatics. Yakugaku Zasshi 109: 179-183.
34. Izaddoost M 1975. Alkaloid chemotaxonomy of the genus Sophora. Phytochemistry 14: 203-204.
35. Kajimoto S, Takanashi N, Kajimoto T, Xu M, Cao J, Masuda Y, Aiuchi T, Nakajo S, Ida Y, Nakaya K 2002. Sophoranone, extracted from a traditional Chinese medicine Shan dou gen, induces apoptosis in human leukemia u937 cells Via formation of reactive oxygen species and opening of mitochondrial permeability transition pores. Int J Cancer 99: 879-890.
36. Kang CM, Shin MK, Lee KS, An DS 1998. Encyclopedia of Chinese Herbs. Seoul: Jung Dam Publisher, p.340-347.
37. Kang SS, Kim JS, Son KH, Chang HW, Kim HP 2000. A new prenylated flavanone from the roots of Sophora flavescens, Fitoterapia 71: 511-515.
38. Kashiwada Y, Nonaka GI, Nishioka I, Yamagishi T 1988. Galloyl and hydroxyl cinnamoylglucoses from Rhubarb. Phytochemistry 27: 1473-1477.
39. Kim DW, Chi YS, Son KH, Chang HW, Kim JS, Kim HP 2002. Effect of sophoraflavanone G, a prenylated flavonoids from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response. Arch Pharm Res 25: 329-335.
40. Kinghorn AD, Balandrin MF, Pelletier SW (Eds.) 1984. Alkaloids. Chemical and Biological Perspectives vol. 2, p. 105.
41. Ko WG, Kang TH, Kim NY, Lee SJ, Kim YC, Ko GI, Ryn SY, Lee BH 2000. Lavandulyl flavonoids: a new class of in vitro apoptogenic agents from Sophora flavescens. Toxicol in Vitro 14: 429-433.
42. Kuroyanagi M, Arakawa T, Hirayama Y, Hayashi T 1999. Antibacterial and antiandrogen flavonoids from Sophora flavescens. J Nat Prod 62: 1595-1599.
43. Lee SW, Lee HS, Nam JY, Kwon OE, Baek AH, Chang JS, Rho MC, Kim YK 2005. Kurarinone isolated from Sophora flavescens Ait., inhibited MCP-1-induced chemotaxis. J Ethnopharmacol 97: 515-519.
44. Li XN, Lu ZQ, Qin S, Yan HX, Yang M, Guan SH, Liu X, Hua HM, Wu LJ, Guo DA 2008. Tonkinensines A and B, two novel alkaloids from Sophora tonkinensis. Tetrahedron Lett 49: 3797-3801.
45. Lin W, Zhang JP, Hu ZL, Qian DH 1997. Inhibitory effect of matrine on lipopolysacchride induced tumor necrosis factor and interleukin-6 production from rat Kupffer cells. Yao Xue Xue Bao 32: 93-96.
46. Liu M, Liu XY, Cheng JF 2003. Advance in the pharmacological research on matrine. Zhongguo Zhong Yao Za Zhi 28: 801-804.
47. Liu Q, Liu M, Mabry TJ, Dixon RA 1994. Flavonol glycosides from Cephalocereus senilis. Phytochemistry 36: 229-231.
48. Liu XJ, Cao MA, LI WH, Shen CH, Yan SQ, Yan CS 2010. Alkaloids from Sophora falvescens Aiton. Fitoterapia 81: 524-527
49. Liu Z, Liu B, Zhang ZT, Zhou TT, Bian HJ, Min MW, Liu YH, Chen J, Bao JK 2008. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells, Phytomedicine 1: 867-875.
50. Lo YH, Lin RD, Lin YP, Liu YL, Lee MH 2009. Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes. J Ethnopharmacol 124: 625-629.
51. Ma SC, Du J, But PPH, Deng XL, Zhang WN, Ooi VEC, Xu HX, Lee SHS Lee SF 2002. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol 79: 205-211.
52. Ma LD, Wen SH, Zhan Y, He YJ, Liu XS, Jiang JK 2008. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med 74: 245-251.
53. Miao KL, Zhang JZ 2001. Research progress on the chemical compounds and pharmacology of Sophora flavescens. Nat Prod Res Dev 13: 69-73.
54. Movsumov IS, Garaev EA., Isaev MI 2006. Alkaloids from Sophora alopecuroides growing in Azerbaijan 1. Sophocarpine, Chem Nat Comp 42: 210-218.
55. Mukhamedova KS, Glushenkova AI 1997. Phospholipids of ripe Sophora japonica seeds. Chem Nat Comp 33: 445-448.
56. Ohyama M, Tanaka T, Yokoyama J, IInuma M 1995. Occurrence of prenylated flavonoids and oligostilbenes and its significance for chemotaxonomy of genus Sophora (Leguminosae). Biochem Syst Ecol 23: 669-677.
57. Ohyama M, Ichise M, Tanaka T, Iinuma M, Charles I, Burandt J 1996. Davidiol D, first naturally occurring resveratrol pentamer isolated from Sophora davidii. Tetrahedron Lett 37: 5155-5158.
58. Olennikov DN, Tankhaeva LM, Sandanov DV 2009. Fatty acids from seeds of Sophora flavescens and Styphnolobium japonicum. Chem Nat Comp 45: 225-226.
59. Paniwnyk L, Beaufoy E, Lorimer JP Mason TJ 2001. The extraction rutin from flower buds of Sophora japonica. Ultrason Sonochem 8: 299-301.
60. Park JA, Kim HJ, Jin C, Lee KT Lee YS 2003. A new pterocarpan, (-)-maackiain sulfate, from the roots of Sophora subprostrata. Arch Pharm Res 26: 1009-1013.
61. Piao XL, Piao XS, Kim SW, Park JH Cai SQ 2006. Identification and characterization of antioxidants from Sophora flavescens. Biol Pharm Bull 29: 1911-1915.
62. Qi Y, Sun A, Liu R, Meng Z, Xie H 2007. Isolation and purification of flavonoid and isoflavonoid compounds from the pericarp of Sophora japonica L. by adsorption chromatography on 12% cross-linked agarose gel media. J Chromatogr 1140: 219-224.
63. Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ Yoon YK 2002. The hair growth promoting effect of Sophora flavescens extract and its molecular regulation. J Dermatological Sci 30: 43-49.
64. Saito K, Arai N, Sekine T, Ohmiya S, Kubo H, Otomasu H, Murakoshi I 1990. Phytoconstituents of S. tonkinensis. Planta Med 56: 487-490
65. Sakamoto S, Kuroyanagi M, Ueno A 1992. Triterpenoid saponins from Sophora subprostrata. Phytochemistry 31: 1339-1342.
66. Sato M, Tsuchiya H, Takase I, Kureshiro H, Tanigaki S and Iinuma M 1995. Antibacterial activity of flavanone isolated from Sophora exigua against methicillinresistant Staphylococcus aureus and its combination with antibiotics. Phytother Res 9: 509-512.
67. +-Glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescents. Bioorg Med Chem 15: 3445-3449.
68. Shirataki Y, Yoshida S, Sugita Y, Yokoe I, Komatsu M, Ohyama M, Tanaka T, Iinuma M 1997. Isoflavanones in roots of Sophora secundiflora. Phytochemistry 44: 710-718.
69. Shirataki Y, Matsuoka S, Komatsu M, Ohyama M, Tanaka T, Iinuma M 1999. Four isoflavanones from roots of Sophora tetraptera. Phytochemistry 50: 695-701.
70. Sohn HY, Son KH, Kwon CS, Kwon GS, Kang SS 2004. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11: 666-672.
71. Sun M, Han J, Duan J, Cui Y, Wang T, Zhang W, Liu W, Hong J, Yao M, Xiong S, Yan X 2007. Novel antitumor activities of Kushen flavonoids in vitro and in vivo. Phytother Res 21: 269-277.
72. Tanaka T, Iinuma M, Asai F, Ohyama M, Burandt B 1997. Flavonoids from the root and stem of Sophora tomentosa, Phytochemistry 46: 1431-1437.
73. Tanaka T, Ito T, Iinuma M, Ohyama M, Ichise M, Tateishi Y 2000. Stilbene oligomers in roots of Sophora davidii. Phytochem 53: 1009-1014.
74. Tanaka T, Ohyama M, Iinuma M, Shirataki Y, Komatsu M, Burandt C 1998. Isoflavonoids from Sophora secundiflora, S. arizonica and S. gypsophila. Phytochem 48: 1187-1193.
75. Tang YP, Lou FC, Wang JH, Zhuang SF 2001. Four new isoflavone triglycosides freom Sophora japonica. J Nat Prod 64: 1107-1110.
76. Tang YP, Hu J, Wang JH, Lou FC 2002. A new coumaronochromone from Sophora japonica. J Asian Nat Prod Res 4: 1-5
77. Terashina S, Shimizu M, Horie S, Morita N 1991. Studies on aldose reductase inhibitors from natural products IV. Constituents and aldose reductase inhibitory effect of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas. Chem Pharm Bull 39: 3346-3347.
78. The Pharmacopoeia of the People's Republic of China 1994. Beijing, China: The Chemical Industry Press 1: p.65.
79. Tse WP, Che CT, Liu K, Lin ZX 2006. Evaluation of the anti-proliferative properties of selected psoriasistreating Chinese medicines on cultured HaCaT cells. J Ethnopharmacol 108: 133-141.
80. Tsoong PC, Ma CY 1981a. A study on the genus Sophora Linn. Acta Phytotax Sinica 19: 1-22.
81. Tsoong PC, Ma CY 1981b. A study on the genus Sophora Linn. (Cont.). Acta Phytotaxon Sinica 19: 143-167.
82. Wang JH, Lou FC, Wang YL, Tang, YP 2003. A flavonol tetraglycoside from Sophora japonica seeds. Phytochemistry 63: 463-465.
83. Watanabe K, Kinjo J, Nohara T 1993. The new isoflavonol glycosides from Lupinus luteus and L polyphenyllus arboreus. Chem Pharm Bull 41: 394-396.
84. Wen M, Mao XJ 2006. Research progress on chemical composition, antiinflammatory and antiallergic activity of Sophora viciifolia. Yunnan J Trad Chinese Med Mat Med 27: 63-64.
85. Xiao PG 1993a. A pictorial encyclopaedia of Chinese medical herbs. Tokyo: Chuokoron-Sha: Jpn. 1. Ed, p. 82.
86. Xiao PG 1993b. A pictorial encyclopaedia of Chinese medical herbs, Tokyo: Chuokoron-Sha: Jpn. 6 ed. p. 95.
87. Xiao P, Kubo H, Komiya H, Higashiyama K, Yan YN, Li JS, Ohmiya S 1999. Lupin alkaloids from seeds of Sophora viciifolia. Phytochemistry 50: 189-193.
88. Xingming Ma, Li H, Yin S, Wang B 2004. Apoptosis in SGC-7901 cells induced by alkaloids from Sophora moorcroftiana seeds. Chin Trad Patent Med 26: 654-657.
89. Xingming Ma, Luo Y, Yu H, Cui Y 2009a. Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro. African J Biotech 5: 1669-1674.
90. Xingming Ma, Yu H, Ying D, Luo Y, Weihua T 2009b. Anti tumor effects of ethanolic extracts from Sophora moorcroftiana seeds in mice. Iranian Redcrescent Med J 11: 19-23.
91. Xing NL, Sha N, Yan HX, Pang XY, Guan SH, Yang M, Hua HM, Wu LJ, Guo DA 2008. Isoprenylated flavonoids from the roots of Sophora tonkinensis. Phytochem Lett 1: 163-167.
92. Xu YL, Ma YB, Xong J 1999. Isoflavonoids of Iristectorrum. Acta Bot Yunnanica 21: 125-130.
93. Yagi A, Fukunaga M, Okuzako N, Mifuchi I, Kawamoto F 1989. Antifungal substances from Sophora flavescens. Shoyakugaku Zasshi 43: 343-347.
94. Yamaki M, Kashihara M, Takagi S 1990. Activity of Kushen compounds against Staphylococcus aureus and Streptococcus mutans. Phytother Re. 4: 235-236.
95. Zhang MJ & Huang J 2004. Recent research progress of antitumor mechanism matrine. Zhongguo Zhong Yao Za Zhi 29: 115-118.
96. Zhang Y, Zhu H, Ye G, Huang C, Yang Y, Chen R, Yu Y, Cui X 2006. Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats. Life Sci 78: 1998-2005.
97. Zhang YF, Wang SZ, Li YY, Xiao ZY, Hu ZL, Zhang JP 2008. Sophocarpine and matrine inhibit the production of TNF and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon 26 adenocarcinoma in mice. Int Immunopharmacol 8: 1767-1772.
98. Zhao HJ, Sun WJ 2005. Research progress on the flavonoids in Sophora flavescens Ait. and their pharmacology. J Chin Med Mat 28: 247-251.
99. Zheng ZH, Dong ZH, She J 1997. Modern studies on traditional Chinese medicine 1. Beijing: Xue Yuan Press. p. 547.
100. Zhou J, Mei Y, Yi L 2008a. Research progress on pharmacology of the alkaloids in Sophora flavescens Ait. J Pediatr Pharm 14: 61-64.
101. Zhou Y, Shan H, Qiao G, Sui X, Lu Y, Yang B 2008b. Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens Ait. Biol Pharm Bull 31: 2057-2062.