Phorbol esters from jatropha meal triggered apoptosis, activated PKC-δ, Caspase-3 proteins and down-regulated the proto-oncogenes in MCF-7 and HeLa cancer cell lines

Molecules

Volumn 17, Issue 9, 2012, Pages 10816-10830

  Oskoueian, Ehsan ^a,b   Abdullah, Norhani ^a   Ahmad, Syahida ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b AGRICULTURAL BIOTECHNOLOGY RESEARCH INSTITUTE OF IRAN ABRII   (Iran)

Author keywords

Anti proliferation; Apoptosis; DNA fragmentation; Gene expression; Jatropha meal; Phorbol esters; Western blot

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; MYC PROTEIN; PHORBOL ESTER; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE C DELTA;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; HELA CELL; HUMAN; ISOLATION AND PURIFICATION; JATROPHA; METABOLISM; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; DOWN-REGULATION; ENZYME ACTIVATION; HELA CELLS; HUMANS; JATROPHA; MCF-7 CELLS; PHORBOL ESTERS; PROTEIN KINASE C-DELTA; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENES; SIGNAL TRANSDUCTION;

EID: 84866891364     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules170910816     Document Type: Article

References (35)

1. Thomas, R.; Sah, N.; Sharma, P. Therapeutic biology of Jatropha curcas: A mini review. Curr. Pharm. Biotechnol. 2008, 9, 315-324.
2. Aiyelaagbe, O.O.; Hamid, A.A.; Fattorusso, E.; Taglialatela Scafati, O. Cytotoxic activity of crude extracts as well as of pure components from Jatropha species, plants used extensively in african traditional medicine. Evid. Based Complementary Altern. Med. 2011, 2011, 1-7.
3. Oskoueian, E.; Abdullah, N.; Ahmad, S.; Saad, W.Z.; Omar, A.R.; Ho, Y.W. Bioactive compounds and biological activities of Jatropha curcas L. kernel meal extract. Int. J. Mol. Sci. 2011, 12, 5955-5970.
4. Oskoueian, E.; Abdullah, N.; Saad, W.Z.; Omar, A.R.; Ahmad, S.; Kuan, W.B.; Zolkifli, N.A.; Hendra, R.; Ho, Y.W. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas L. J. Med. Plants Res. 2011, 5, 49-57.
5. Namuli, A.; Abdullah, N.; Sieo, C.C.; Zuhainis, S.W.; Oskoueian, E. Phytochemical compounds and antibacterial activity of Jatropha curcas Linn. extracts. J. Med. Plants Res. 2011, 5, 3982-3990.
6. Murugesan, A.; Umarani, C.; Subramanian, R.; Nedunchezhian, N. Bio-diesel as an alternative fuel for diesel engines - A review. Renew. Sust. Energ. Rev. 2009, 13, 653-662.
7. Devappa, R.K.; Makkar, H.P.S.; Becker, K. Nutritional, biochemical, and pharmaceutical potential of proteins and peptides from Jatropha: Review. J. Agric. Food Chem. 2010, 58, 6543-6555.
8. Oskoueian, E.; Abdullah, N.; Saad, W.Z.; Omar, A.R.; Puteh, M.B.; Ho, Y.W. Anti-nutritional metabolites and effect of treated Jatropha curcas kernel meal on rumen fermentation in vitro. J. Anim. Vet. Adv. 2011, 10, 214-220.
9. Goel, G.; Makkar, H.P.S.; Francis, G.; Becker, K. Phorbol esters: Structure, biological activity, and toxicity in animals. Int. J. Toxicol. 2007, 26, 279-288.
10. Haas, W.; Mittelbach, M. Novel 12-deoxy-16-hydroxyphorbol diesters isolated from the seed oil of Jatropha curcas. J. Nat. Prod. 2002, 65, 1434-1440.
11. Kazanietz, M.G. Targeting protein kinase C and "non-kinase" phorbol ester receptors: Emerging concepts and therapeutic implications. BBA-Proteins Proteom. 2005, 1754, 296-304.
12. Makkar, H.P.S.; Siddhuraju, P.; Becker, K. Methods in Molecular Biology: Plant Secondary Metabolites; Humana Press:Totowa, NJ, USA, 2007; pp. 93-100.
13. Li, C.Y.; Devappa, R.K.; Liu, J.X.; Lv, J.M.; Makkar, H.P.S.; Becker, K. Toxicity of Jatropha curcas phorbol esters in mice. Food Chem. Toxicol. 2009, 48, 620-625.
14. Avila, G.E.; Zheng, X.; Cui, X.X.; Ryan, A.D.; Hansson, A.; Suh, J.; Rabson, A.B.; Chang, R.L.; Shih, W.J.; Lin, Y. Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. J. Pharmacol. Exp. Ther. 2005, 315, 170-187.
15. Bond, J.A.; Gescher, A.J.; Verschoyle, R.D.; Lemoine, N.R.; Errington, R.; Wiltshire, M.; Smith, P.J.; Wynford Thomas, D. Cytotoxic action of phorbol esters on human pancreatic cancer cells. Int. J. Cancer 2007, 121, 1445-1454.
16. Day, M.; Zhao, X.; Wu, S.; Swanson, P.; Humphrey, P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and C-fos activation in androgen-sensitive prostate cancer cells. Cell Growth Differ. 1994, 5, 735-741.
17. Hatton, J.P.; Gaubert, F.; Cazenave, J.-P.; Schmitt, D. Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells. J. Cell. Biochem. 2002, 87, 39-50.
18. Udou, T.; Hachisuga, T.; Tsujioka, H.; Kawarabayashi, T. The role of c-jun protein in proliferation and apoptosis of the endometrium throughout the menstrual cycle. Gynecol. Obstet. Inves. 2004, 57, 121-126.
19. Oh, J.I.; Chun, K.H.; Joo, S.H.; Oh, Y.T.; Lee, S.K. Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. Cancer Lett. 2005, 230, 228-238.
20. Harborne, J.B.; Williams, C.A. Advances in flavonoid research since 1992. Phytochemistry 2000, 55, 481-504.
21. Chen, J.; Giridhar, K.V.; Zhang, L.; Xu, S.; Wang, Q.J. A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-κB activities. Carcinogenesis 2011, 32, 1198-1206.
22. Cheftel, J.C. Emerging risks related to food technology. In Advances in Food Protection; Hefnawy, M., Ed.; Springer: Dordrecht, The Netherlands, 2011; pp. 223-254.
23. Lai, J.M.; Hsieh, C.L.; Chang, Z.F. Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction. J. Cell Sci. 2003, 116, 3491-3501.
24. Laouar, A.; Glesne, D.; Huberman, E. Protein kinase C-β, fibronectin, α5β1-integrin, and tumor necrosis factor-α are required for phorbol diester-induced apoptosis in human myeloid leukemia cells. Mol. Carcinogen. 2001, 32, 195-205.
25. Hofmann, J. Protein kinase C isozymes as potential targets for anticancer therapy. Curr. Cancer Drug Tar. 2004, 4, 125-146.
26. Fujii, T.; Garcia-Bermejo, M.L.; Bernabo, J.L.; Caamano, J.; Ohba, M.; Kuroki, T.; Li, L.; Yuspa, S.H.; Kazanietz, M.G. Involvement of protein kinase C (PKC) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. J. Biol. Chem. 2000, 275, 7574-7582.
27. Park, I.C.; Park, M.J.; Rhee, C.H.; Lee, J.I.; Choe, T.B.; Jang, J.J.; Lee, S.H.; Hong, S.I. Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line. Int. J. Oncol. 2001, 18, 1077-1083.
28. Association of Official Analytical Chemists (AOAC). Official Methods of Analysis, 17th ed.; AOAC: Washington, DC, USA, 2000; pp. 89-110.
29. Sharif, R.; Ghazali, A.; Rajab, N.; Haron, H.; Osman, F. Toxicological evaluation of some Malaysian locally processed raw food products. Food Chem. Toxicol. 2008, 46, 368-374.
30. Darzynkiewicz, Z.; Juan, G. Selective extraction of fragmented DNA from apoptotic cells for analysis by gel electrophoresis and identification of apoptotic cells by flow cytometry. In DNA Repair Protocols: Eukaryotic Systems; Henderson, D.S., Ed.; Humana Press: New York, NY, USA, 1999; Volume 113, pp. 599-606.
31. Vandesompele, J.; De Preter, K.; Pattyn, F.; Poppe, B.; Van Roy, N.; De Paepe, A.; Speleman, F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3, 1-11.
32. Oxelmark, E.; Roth, J.M.; Brooks, P.C.; Braunstein, S.E.; Schneider, R.J.; Garabedian, M.J. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol. Cell. Biol. 2006, 26, 5205-5213.
33. Hu, D.G.; Mackenzie, P.I. Estrogen receptor α, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17β-estradiol in MCF-7 cells. Mol. Pharmacol. 2009, 76, 425-439.
34. Rangatia, J.; Vangala, R.K.; Treiber, N.; Zhang, P.; Radomska, H.; Tenen, D.G.; Hiddemann, W.; Behre, G. Downregulation of c-Jun expression by transcription factor C/EBPα is critical for granulocytic lineage commitment. Mol. Cell. Biol. 2002, 22, 8681-8694.
35. SAS. SAS, Statistical Analysis Institute (Version 9.1.3). SAS Institute Inc.: Cary, NC, USA, 2003.