Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction

Journal of Cell Science

Volumn 116, Issue 17, 2003, Pages 3491-3501

  Lai, Jin Mei ^a   Hsieh, Chia Ling ^a   Chang, Zee Fen ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase; Myosin light chain; Phosphorylation; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CASPASE 10; CASPASE 3; CASPASE 8; ENZYME INHIBITOR; LYSOPHOSPHATIDIC ACID; MYOSIN; MYOSIN LIGHT CHAIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; RHO KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL FATE; CELL LINE; CELL SURVIVAL; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ERYTHROBLAST; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMIDES; APOPTOSIS; CARCINOGENS; CASPASE 10; CASPASE 3; CASPASE 8; CASPASES; CELL ADHESION; CLONING, MOLECULAR; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROBLASTS; HUMANS; LYSOPHOSPHOLIPIDS; MICROSCOPY, FLUORESCENCE; MYOSIN LIGHT CHAINS; MYOSINS; PHORBOL ESTERS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RECEPTORS, TUMOR NECROSIS FACTOR; RHO GTP-BINDING PROTEINS;

ANIMALIA;

EID: 0042328372     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00660     Document Type: Article

References (48)

1. Aepfelbacher, M. (1995). ADP-ribosylation of Rho enhances adhesion of U937 cells to fibronectin via the alpha 5 beta 1 integrin receptor. FEBS Lett. 363, 78-80.
2. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y. and Kaibuchi, K. (1996). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-20249.
3. Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y. and Kaibuchi, K. (1997). Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275, 1308-1311.
4. Amano, M., Fukata, Y. and Kaibuchi, K. (2000). Regulation and functions of Rho-associated kinase. Exp. Cell Res. 261, 44-51.
5. Ashkenazi, A. and Dixit, V. M. (1998). Death receptors: signaling and modulation. Science 281, 1305-1308.
6. Bar-Sagi, D. and Hall, A. (2000). Ras and Rho GTPases: a family reunion. Cell 103, 227-238.
7. Bishop, A. L. and Hall, A. (2000). Rho GTPases and their effector proteins. Biochem. J. 348, 241-255.
8. Coleman, M. L. and Olson, M. F. (2002). Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ. 9, 493-504.
9. Coleman, M. L., Sahai, E. A., Yeo, M., Bosch, M., Dewar, A. and Olson, M. F. (2001). Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol. 3, 339-345.
10. Collins, S. J. (1987). The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70, 1233-1244.
11. Day, M. L., Zhao, X., Wu, S., Swanson, P. E. and Humphrey, P. A. (1994). Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Cell Growth Differ. 5, 735-741.
12. Gallagher, P. J., Herring, B. P. and Stull, J. T. (1997). Myosin light chain kinases. J. Muscle Res. Cell Motil. 18, 1-16.
13. Garzotto, M., White-Jones, M., Jiang, Y., Ehleiter, D., Liao, W. C., Haimovitz-Friedman, A., Fuks, Z. and Kolesnick, R. (1998). 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Res. 58, 2260-2264.
14. Goetzl, E. J. and An, S. (1998). Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12, 1589-1598.
15. Gunji, H., Hass, R. and Kufe, D. (1992). Internucleosomal DNA fragmentation during phorbol ester-induced monocytic differentiation and G0/G1 arrest. J. Clin. Invest. 89, 954-960.
16. Ishikawa, T., Chijiwa, T., Hagiwara, M., Mamiya, S., Saitoh, M. and Hidaka, H. (1988). ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol. Pharmacol. 33, 598-603.
17. Itoh, K., Hara, T., Yamada, F. and Shibata, N. (1992). Diphosphorylation of platelet myosin ex vivo in the initial phase of activation by thrombin. Biochim. Biophys. Acta 1136, 52-56.
18. Jin, Y., Atkinson, S. J., Marrs, J. A. and Gallagher, P. J. (2001). Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1. J. Biol. Chem. 276, 30342-30349.
19. Kaibuchi, K., Kuroda, S. and Amano, M. (1999). Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu. Rev. Biochem. 68, 459-486.
20. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K. et al. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.
21. Kischkel, F. C., Lawrence, D. A., Tinel, A., LeBlanc, H., Virmani, A., Schow, P., Gazdar, A., Blenis, J., Arnott, D. and Ashkenazi, A. (2001). Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J. Biol. Chem. 276, 46639-46646.
22. Kizaki, H., Tadakuma, T., Odaka, C., Muramatsu, J. and Ishimura, Y. (1989). Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143, 1790-1794.
23. Kohama, K., Ye, L. H., Hayakawa, K. and Okagaki, T. (1996). Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin. Trends Pharmacol. Sci. 17, 284-287.
24. Kulms, D., Dussmann, H., Poppelmann, B., Stander, S., Schwarz, A. and Schwarz, T. (2002). Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1). Cell Death Differ. 9, 598-608.
25. Lai, J. M., Lu, C. Y., Yang-Yen, H. F. and Chang, Z. F. (2001). Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion. Biochem. J. 359, 227-233.
26. Lai, J. M., Wu, S., Huang, D. Y. and Chang, Z. F. (2002). Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells. Mol. Cell Biol. 22, 7581-7592.
27. Lotem, J., Cragoe, E. J., Jr and Sachs, L. (1991). Rescue from programmed cell death in leukemic and normal myeloid cells. Blood 78, 953-960.
28. Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K. (1996). Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15, 2208-2216.
29. McCarthy, N. J., Whyte, M. K., Gilbert, C. S. and Evan, G. I. (1997). Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol. 136, 215-227.
30. Meng, X. W., Heldebrant, M. P. and Kaufmann, S. H. (2002). Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain. J. Biol. Chem. 277, 3776-3783.
31. Mills, J. C., Stone, N. L., Erhardt, J. and Pittman, R. N. (1998). Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J. Cell Biol. 140, 627-636.
32. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R. et al. (1996). FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85, 817-827.
33. Narumiya, S., Ishizaki, T. and Uehata, M. (2000). Use and properties of ROCK-specific inhibitor Y-27632. Methods Enzymol. 325, 273-284.
34. Olson, M. F., Paterson, H. F. and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394, 295-299.
35. Qiu, R. G., Chen, J., McCormick, F. and Symons, M. (1995). A role for Rho in Ras transformation. Proc. Natl. Acad. Sci. USA 92, 11781-11785.
36. Ratcliffe, M. J., Smales, C. and Staddon, J. M. (1999). Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli. Biochem. J. 338, 471-478.
37. Sahai, E., Olson, M. F. and Marshall, C. J. (2001). Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20, 755-766.
38. Sebbagh, M., Renvoize, C., Hamelin, J., Riche, N., Bertoglio, J. and Breard, J. (2001). Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat. Cell Biol. 3, 346-352.
39. Soeno, Y., Shimada, Y. and Obinata, T. (1999). BDM (2,3-butanedione monoxime), an inhibitor of myosin-actin interaction, suppresses myofibrillogenesis in skeletal muscle cells in culture. Cell Tissue Res. 295, 307-316.
40. Spector, I., Shochet, N. R., Blasberger, D. and Kashman, Y. (1989). Latrunculins - novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. Cell Motil. Cytoskeleton 13, 127-144.
41. Strasser, A., O'Connor, L. and Dixit, V. M. (2000). Apoptosis signaling. Annu. Rev. Biochem. 69, 217-245.
42. Stupack, D. G., Puente, X. S., Boutsaboualoy, S., Storgard, C. M. and Cheresh, D. A. (2001). Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J. Cell Biol. 155, 459-470.
43. Takada, Y., Hachiya, M., Osawa, Y., Hasegawa, Y., Ando, K., Kobayashi, Y. and Akashi, M. (1999). 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells. J. Biol. Chem. 274, 28286-28292.
44. Thornberry, N. A. and Lazebnik, Y. (1998). Caspases: enemies within. Science 281, 1312-1316.
45. Vincenz, C. and Dixit, V. M. (1997). Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. 272, 6578-6583.
46. Wang, J., Chun, H. J., Wong, W., Spencer, D. M. and Lenardo, M. J. (2001). Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. USA 98, 13884-13888.
47. Watanabe, Y., Ito, M., Kataoka, Y., Wada, H., Koyama, M., Feng, J., Shiku, H. and Nishikawa, M. (2001). Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion. Blood 97, 3798-3805.
48. Yang, X., Chang, H. Y. and Baltimore, D. (1998). Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell 1, 319-325.