Toxicity of Jatropha curcas phorbol esters in mice

Food and Chemical Toxicology

Volumn 48, Issue 2, 2010, Pages 620-625

  Li, Cai Yan ^a   Devappa, Rakshit K ^b   Liu, Jian Xin ^a   Lv, Jian Min ^c   Makkar, H P S ^b   Becker, K ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF HOHENHEIM   (Germany)

^c ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Histopathology; Jatropha curcas; LD50; Mice; Phorbol esters; Toxicity

Indexed keywords

PHORBOL ESTER; VEGETABLE OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BRAIN CELL; CONTROLLED STUDY; GLOMERULOSCLEROSIS; HEART DISEASE; HEART MUSCLE CELL; HISTOPATHOLOGY; JATROPHA; JATROPHA CURCAS; KIDNEY ATROPHY; LETHAL DOSE; LUNG HEMORRHAGE; MORTALITY; MOUSE; NONHUMAN; PLANT SEED; TOXICOLOGY;

ADMINISTRATION, ORAL; ANIMAL FEED; ANIMALS; CEREBRAL CORTEX; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HEART; HEMORRHAGE; JATROPHA; LETHAL DOSE 50; LUNG DISEASES; MALE; MICE; MYOCYTES, CARDIAC; PHORBOL ESTERS; PLANT EXTRACTS; SPECIFIC PATHOGEN-FREE ORGANISMS;

JATROPHA; JATROPHA CURCAS; MUS;

EID: 74649086297     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.11.042     Document Type: Article

References (29)

1. Abd-Elhamid H.F. Investigation of induced biochemical and histopathological parameters of acetonitrile extract of Jatropha curcas in albino rats. J. Egypt. Soc. Parasitol. 34 2 (2004) 397-406
2. Adam S.E.I. Toxic effects of Jatropha curcas in mice. Toxicology 2 (1974) 67-76
3. Adam S.E.I., and Magzoub M. Toxicity of Jatropha curcas for goats. Toxicology 4 3 (1975) 347-354
4. Ahmed O.M., and Adam S.E. Toxieity of Jatropha curcas in sheep and goats. Res. Vet. Sei. 27 1 (1979) 89-96
5. Chivandi E., Makuza S.M., Erlanger K.H., Mtimuni J.P., Read J.S., and Tivapasi M. Effects of dietary Jatropha curcas on the haematology of weaned pigs. Zimbabwe Vet. J. 31 4 (2000) 83-91
6. Devappa R.K., and Bhagya S. Biochemical and nutritional evaluation of Jatropha protein isolate prepared by steam injection heating for reduction of toxic and antinutritional factors. J. Sci. Food Agric. 88 (2008) 911-919
7. Gadir A., Onsa T.O., Ali W.E.M., El Badwi S.M.A., and Adam S.E.I. Comparative toxicity of Croton macrostachys, Jatropha curcas, Piper abyssinica seeds in Nubian goats. Small Ruminant Res. 48 1 (2003) 61-67
8. Gandhi V.M., Cherian K.M., and Mulky M.J. Toxicological studies on Ratanjyot oil. Food Chem. Toxicol. 33 1 (1995) 39-42
9. Goel G., Makkar H.P.S., Francis G., and Becker K. Phorbol esters: structure, biological activity and toxicity in animals. Int. J. Toxicol. 26 (2007) 279-288
10. Goonesekera M.M., Gunawardana V.K., Jayasena K., Mohammed S.G., and Balasubramaniam S. Pregnancy terminating effect of Jatropha Curcas in rats. J. Ethnopharmacol. 47 (1995) 117-123
11. Gübitz G.M., Mittelbach M., and Trabi M. Exploitation of the tropical oil seed plant Jatropha curcas L. Bioresource Technol. 67 (1999) 73-82
12. Haas W., Strerk H., and Mittelbach M. Novel 12 deoxy-16-hydroxyphorbol diesters isolates from the seed oil of Jatropha curcas. J. Nat. Prod. 65 (2002) 1434-1440
13. Horiuchi T., Suttajit M., Suguri H., Endo Y., Shudo K., Wongchai V., Hecker E., and Fujiki H. A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diesters of 12-deoxy-16-hydroxyphorbol. Cancer Res. 48 20 (1988) 5800-5804
14. 50) using Bliss method. J. Math. Med. 4 (1995) 318-320
15. Liberalino A.A.A., Bambirra E.A., Moraes-Santos T., and Viera C.E. Jatropha curcas L. seeds. Chemical analysis and toxicity. Braz. Arch. Biol. Technol. 31 (1988) 539-550
16. Makkar H.P.S., Aderibigbe A.O., and Becker K. Comparative evaluation of nontoxic and toxic varieties of Jatropha curcas for chemical composition, digestibility, protein degradability and toxic factors. Food Chem. 62 2 (1998) 207-215
17. Makkar H.P.S., and Becker K. Jatropha curcas an exciting crop for generation of biofuel and value-added products. Eur. J. Lipid Sci. Technol. 11 8 (2009) 773-787
18. Makkar H.P.S., Becker K., Sporer F., and Wink M. Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas. J. Agric. Food Chem. 45 (1997) 3152-3157
19. Makkar H.P.S., Martinez-Herrera J., and Becker K. Variations in seed number per fruit, seed physical parameters and contents of oil, protein and phorbol ester in toxic and non-toxic genotypes of Jatropha curcas. J. Plant Sci. 3 4 (2008) 260-265
20. Makkar H.P.S., Siddhuraju P., and Becker K. A Laboratory Manual on Quantification of Plant Secondary Metabolites (2007), Human Press, Totowa, New Jersey p. 130
21. Mariz S.R., Arauojo W.C., Cerqueira G.S., Araujo W.C., Duarte J.C., Diniz M.F.F.M., and Medeiros I.A. Avaliacao histopatologica em ratros apos tratamento agudo com o extrato etanolico de partes aereas de Jatropha gossypiifolia L. Braz. J. Pharmacog. 18 2 (2008) 213-216
22. Mariz S.R., Cerqueira G.S., Arauojo W.C., Duarte J.C., Melo A.F.M., Santos H.B., Oliveria K., Diniz M.F.F.M., and Medeiros I.A. Estudo toxicologixo agudo do extrato ethanolico de partes aereas de Jatopha gossypiifolia L. em ratos. Braz. J. Pharmacog. 16 3 (2006) 372-378
23. Odusote O.M., Abioye A.O., and Rotib M.O. Jatropha curcas seed oil Linn (Euphorbiaceae) contraceptive activity and on oral formulation. Nig. Quart. J. Hosp. Med. 12 1-4 (2002) 44-47
24. Oluwole F.S., and Bolarinwa F. Jatropha curcas extract causes anemia in rat. Phytother. Res. 11 (1997) 538-539
25. Rakshit K.D., Darukeshwara J., Rathina Raj K., Narasimhamurthy K., Saibaba P., and Bhagya S. Toxicity studies of detoxified Jatropha meal (Jatropha curcas) in rats. Food Chem. Toxicol. 46 (2008) 3621-3625
26. Sun R.Y. NDST (New Drug Statistic) Version 8.0 (1998), Wan-Nan Medical College, Wuhu, China
27. The State Food and Drug Administration of People's Republic of China. Regulatory Guide on the Techniques for Drug Researches (2005), Chinese Medical Science and Technology Press, Beijing pp. 83-93
28. Trebien H.A., Neves P.C.A., Yunes R.A., and Calixto J.B. Evaluation of pharmacological activity of crude hydroalcoholic extract from Jatropha elliptica. Phytother. Res. 2 3 (1988) 115-118
29. Zhou H.J. Statistical Methods for Biological Test (1988), People's Medical Publishing House, Beijing p. 214