Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit

Molecular Pharmacology

Volumn 82, Issue 4, 2012, Pages 711-718

  Beissner, Mirko ^a   Dutertre, Sébastien ^b   Schemm, Rudolf ^c   Danker, Timm ^d   Sporning, Annett ^e   Grubmul̈ler, Helmut ^c   Nicke, Annette ^a,e  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d NMI Technologietransfer GmbH   (Germany)

^e MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALANINE; ALPHA CONOTOXIN [A10L]TXIA; ALPHA CONOTOXIN MII; ALPHA CONOTOXIN TXIA; ARGININE; CONOTOXIN; GLUTAMIC ACID; LYSINE; NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR BLOCKING AGENT; PROLINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTRODE; GENE MUTATION; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; VOLTAGE CLAMP;

ACETYLCHOLINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CONOTOXINS; FEMALE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NICOTINIC AGONISTS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC; SEQUENCE ALIGNMENT; XENOPUS LAEVIS;

EID: 84866875613     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.078683     Document Type: Article

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