Cellular uptake of β2M and AGE-β2M in synovial fibroblasts and macrophages

Nephrology Dialysis Transplantation

Volumn 18, Issue 1, 2003, Pages 46-53

  O'Neill, Kalisha D ^a   Chen, Neal X ^a   Wang, Mu ^a   Cocklin, Ross ^a   Zhang, Yilong ^a   Moe, Sharon M ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RICHARD L ROUDEBUSH VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

2 microglobulin; Advanced glycation; Dialysis amyloidosis; End products; Endocytosis; Macrophages; Synovial fibroblasts

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID; BETA 2 MICROGLOBULIN; CYTOKINE; FLUOROCHROME; INTERSTITIAL COLLAGENASE; ARGININE; DRUG DERIVATIVE; LYSINE; PENTOSIDINE;

AMYLOIDOSIS; ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOCYTOSIS; ENDOSOME; FIBROBLAST; FLUOROCHROME STAINING; HEMODIALYSIS PATIENT; HUMAN; HUMAN TISSUE; INTRACELLULAR TRANSPORT; MACROPHAGE; MOLECULAR MECHANICS; MONOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; SYNOVIUM; CYTOLOGY; ELECTRON MICROSCOPY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; OSTEOARTHRITIS; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ARGININE; BETA 2-MICROGLOBULIN; BIOLOGICAL TRANSPORT; CELLS, CULTURED; ENDOCYTOSIS; FIBROBLASTS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; LYSINE; MACROPHAGES; MICROSCOPY, ELECTRON; MONOCYTES; OSTEOARTHRITIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SYNOVIAL MEMBRANE;

EID: 0037236705     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/18.1.46     Document Type: Article

References (27)

1. Sprague SM, Moe SM. Clinical manifestations and pathogenesis of dialysis-related amyloidosis. Semin Dial 1996; 9: 360-369
2. Jadoul M, Garbar C, Noel H et al. Histological prevalence of beta 2-microglobulin amyloidosis in hemodialysis: a prospective post-mortem study. Kidney Int 1997; 51: 1928-1932
3. Ehlerding G, Schaeffer J, Drommer W, Miyata T, Koch KM, Floege J. Alterations of synovial tissue and their potential role in the deposition of beta2-microglobulin-associated amyloid. Nephrol Dial Transplant 1998; 13: 1465-1475
4. Argiles A, Mourad G, Kerr PG, Garcia M, Collins B, Demaille JG. Cells surrounding haemodialysis-associated amyloid deposits are mainly macrophages. Nephrol Dial Transplant 1994; 9: 662-667
5. Garcia-Garcia M, Argiles, Gouin-Charnet A, Durfort M, Garcia-Valero J, Mourad G. Impaired lysosomal processing of beta2-microglobulin by infiltrating macrophages in dialysis amyloidosis. Kidney Int 1999; 55: 899-906
6. Nguyen-Simonnet H, Vincent C, Gauthier C, Revillard JP, Pellet MV. Turnover studies of human beta 2-microglobulin in the rat: evidence for a beta 2-microglobulin-binding plasma protein. Clin Sci 1982; 62: 403-410
7. Sundin DP, Cohen M, Dahl R, Falk S, Molitoris BA. Characterization of the beta 2-microglobulin endocytic pathway in rat proximal tubule cells. Am J Physiol 1994; 267: F380-389
8. Vlassara H. Recent progress on the biologic and clinical significance of advanced glycosylation end products. J Lab Clin Med 1994; 124: 19-30
9. Miyata T, Oda O, Inagi R et al. Beta 2-microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis. J Clin Invest 1993; 92: 1243-1252
10. Iida Y, Miyata T, Inagi R, Sugiyama S, Maeda K. Beta 2-microglobulin modified with advanced glycation end products induces interleukin-6 from human macrophages: role in the pathogenesis of hemodialysis-associated amyloidosis. Biochem Biophys Res Commun 1994; 201: 1235-1241
11. Matsuo K, Ikizler TA, Hoover RL et al. Transforming growth factor-beta is involved in the pathogenesis of dialysis-related amyloidosis. Kidney Int 2000; 57: 697-708
12. Moe SM, Singh GK, Bailey AM. Beta2-microglobulin induces MMP-1 but not TIMP-1 expression in human synovial fibroblasts. Kidney Int 2000; 57: 2023-2034
13. Jaradat MI, Schnizlein-Bick CT, Singh GK, Moe SM. Beta2-microglobulin increases the expression of vascular cell adhesion molecule on human synovial fibroblasts. Kidney Int 2001; 59:1951-1959
14. Chen NX, O'Neill KD, Niwa T, Moe SM. Signal transduction of beta2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts. Kidney Int 2002; 61: 414-424
15. Owen WF, Jr, Hou FF, Stuart RO et al. Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int 1998; 53: 1365-1373
16. van Deurs B, Petersen OW, Olsnes S, Sandvig K. The ways of endocytosis. Int Rev Cytol 1989; 117: 131-177.
17. Sundin DP, Sandoval R, Molitoris BA. Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. J Am Soc Nephrol 2001; 12: 114-123
18. Bernabeu C, van de Rijn M, Lerch PG, Terhorst CP. Beta 2-microglobulin from serum associates with MHC class I antigens on the surface of cultured cells. Nature 1984; 308: 642-645
19. Huet C, Ash JF, Singer SJ. The antibody-induced clustering and endocytosis of HLA antigens on cultured human fibroblasts. Cell 1980; 21: 429-438
20. Skov S. Intracellular signal transduction mediated by ligation of MHC class I molecules. Tissue Antigens 1998; 51: 215-223
21. Rock KL, Gamble S, Rothstein L, Gramm C, Benacerraf B. Dissociation of beta 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell 1991; 65: 611-620
22. Miyata T, Hori O, Zhang J et al. The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis. J Clin Invest 1996; 98: 1088-1094
23. Smedsrod B, Melkko J, Araki N, Sano H, Horiuchi S. Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. Biochemistry J 1997; 322: 567-573
24. Yang Z, Makita Z, Horii Y et al. Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins. J Exp Med 1991; 174: 515-524
25. Garbar C, Jadoul M, Noel H, van Ypersele de Strihou C. Histological characteristics of sternoclavicular beta 2-microglobulin amyloidosis and clues for its histogenesis. Kidney Int 1999; 55: 1983-1990
26. Niwa T, Sato M, Katsuzaki T et al. Amyloid beta 2-microglobulin is modified with N epsilon-(carboxymethyl)lysine in dialysis-related amyloidosis. Kidney Int 1996; 50: 1303-1309
27. Brancaccio D, Gallieni M, Niwa T, Braidotti P, Coggi G. Ultrastructural localization of advanced glycation end products and beta2-microglobulin in dialysis amyloidosis. J Nephrol 2000; 13: 129-136