Adherence to HAART: A systematic review of developed and developing nation patient-reported barriers and facilitators

PLoS Medicine

Volumn 3, Issue 11, 2006, Pages 2039-2064

  Mills, Edward J ^a   Nachega, Jean B ^a,b   Bangsberg, David R ^c   Singh, Sonal ^a,b   Rachlis, Beth ^d   Wu, Ping ^e   Wilson, Kumanan ^a,f   Buchan, Iain ^g   Gill, Christopher J ^h   Cooper, Curtis ^a,i  

^a Centre for International Health and Human Rights Studies   (Canada)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e CANADIAN COLLEGE OF NATUROPATHIC MEDICINE   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h BOSTON UNIVERSITY   (United States)

ⁱ UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

CLINICAL TRIAL; DATA BASE; DEVELOPED COUNTRY; DEVELOPING COUNTRY; ECONOMIC ASPECT; HEALTH SURVEY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICAL LITERATURE; META ANALYSIS; MORTALITY; PREVALENCE; QUALITATIVE ANALYSIS; QUALITY OF LIFE; QUANTITATIVE ANALYSIS; REVIEW; SYSTEMATIC REVIEW; PATIENT COMPLIANCE;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; HUMANS; PATIENT COMPLIANCE;

EID: 33845286853     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030438     Document Type: Review

References (108)

1. Hogg RS, O'Shaughnessy MV, Gataric N, Yip B, Craib K, et al. (1997) Decline in deaths from AIDS due to new antiretrovirals. Lancet 349: 1294.
2. Mannheimer SB, Matts J, Telzak E, Chesney M, Child C, et al. (2005) Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence. AIDS Care 1: 10-22.
3. Altice FL, Mostashari F, Friedland GH (2001) Trust and the acceptance of and adherence to antiretroviral therapy. J Acquir Immune Defic Syndr 1: 47-58.
4. Ferguson T, Stewart KE, Funkhouser E, Tolson J, Westfall AO, et al. (2002) Patient-percieved barriers to antiretroviral adherence: associations with race. AIDS Care 5: 607-617.
5. Friedland G, Williams A (1999) Attaining higher goals in HIV treatment: The central importance of adherence. AIDS (Suppl 1): S61-S72.
6. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, et al. (2000) Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 1: 21-30.
7. Bangsberg DR, Hecht FM, Charlebois ED, Zolopa AR, Holodniy M, et al. (2000) Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS 4: 357-366.
8. Bangsberg DR, Charlebois ED, Grant RM, Holodniy M, Deeks SG, et al. (2003) High levels of adherence do not prevent accumulation of HIV drug resistance mutations. AIDS 13: 1925-1932.
9. Bangsberg DR, Perry S, Charlebois ED, Clark RA, Roberston M, et al. (2001) Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS 9: 1181-1183.
10. Wood E, Hogg RS, Yip B, Harrigan PR, O'Shaughnessy MV, et al. (2003) Is there a baseline CD4 cell count that precludes a survival response to modern antiretroviral therapy? AIDS 5: 711-720.
11. Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, et al. (2006) Adherence to antiretroviral therapy in sub-Saharan Africa and North America: A meta-analysis. JAMA 6: 679-690.
12. United Nations Development Programme (2004) Human Development Reports. Available: http://hdr.undp.org. Accessed 4 October 2006.
13. Mills E, Jadad AR, Ross C, Wilson K (2005) Systematic review of qualitative studies exploring parental beliefs and attitudes toward childhood vaccination identifies common barriers to vaccination. J Clin Epidemiol 11: 1081-1088.
14. Freeman MF, Tukey JW (1950) Transformations related to the angular and the square root. Ann Math Stat: 607-611.
15. Fleiss JL (1993) The statistical basis of meta-analysis. Stat Methods Med Res 2: 121-145.
16. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 3: 177-188.
17. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 11: 1539-1558.
18. Abel E, Painter L (2003) Factors that influence adherence to HIV medications: Perceptions of women and health care providers. J Assoc Nurses AIDS Care 4: 61-69.
19. Golin C, Isasi F, Bontempi JB, Eng E (2002) Secret pills: HIV-positive patients' experiences taking antiretroviral therapy in North Carolina. AIDS Educ Prev 4: 318-329.
20. Miller L, Huffman HB, Weidmer BA, Hays RD (2002) Patient preferences regarding antiretroviral therapy. Int J STD AIDS 13: 593-601.
21. Misener T, Sowell RL (1998) HIV-infected women's decisions to take antiretrovirals. West J Nurs Res 4: 431-447.
22. Murphy D, Johnston Roberts K, Martin DJ, et al. (2000) Barriers to antiretroviral adherence among HIV-infected adults. AIDS Patient Care STDS 1: 47-58.
23. Murphy D, Johnston Roberts K, Hoffman D, et al. (2003) Barriers and successful strategies to antiretroviral adherence among HIV-infected monolingual Spanish-speaking patients. AIDS Care 2: 217-230.
24. Powell-Cope G, White J, Henkelman EJ, Turner BJ (2003) Qualitative and quantitative assessments of HAART adherence of substance abusing women. AIDS Care 2: 239-249.
25. Proctor V, Tesfa A, Tompkins DC (1999) Barriers to adherence to highly active antiretroviral therapy as expressed by people living with HIV/AIDS. AIDS Patient Care STDS 9: 535-544.
26. Richter D, Sowell RL, Pluto DM (2002) Attitudes toward antiretroviral therapy among African American women. Am J Health Behav 1: 25-33.
27. Schilder A, Kennedy C, Goldstone IL, Ogden RD, Hogg RS, et al. (2001) "Being dealt with as a whole person." Care seeking and adherence: The benefits of culturally competent care. Soc Sci Med 52: 1643-1659.
28. Stone V, Clarke J, Lovell J, Steger KA, Hirschhorn LR, et al. (1998) HIV/AIDS patients' perspectives on adhering to regimens containing protease inhibitors. J Gen Intern Med 13: 586-593.
29. Westerfelt A (2004) A qualitative investigation of adherence issues for men who are HIV positive. Social Work 2: 231-240.
30. Adamian M, Golin CE, Shain LS, DeVellis B (2004) Brief motivational interviewing to improve adherence to antiretroviral therapy: Development and qualitative plot assessment of an intervention. AIDS Patient Care STDS 4: 229-238.
31. Barton Laws M, Wilson IB, Bowser DM, Kerr SE (2000) Taking antiretroviral therapy for HIV infection: Learning from patients' stories. J Gen Intern Med: 848-858.
32. Graney M, Bunting SM, Russell CK (2003) HIV/AIDS medication adherence factors: Inner-city clinic patients' self-reports. Tenn Med 2: 73-78.
33. Hill Z, Kendall C, Fernandez M (2003) Patterns of adherence to antiretrovirals: Why adherence has no simple measure. AIDS Patient Care STDS 10: 519-525.
34. Johnston Roberts K (2002) Physician-patient relationships, patient satisfaction and antiretroviral medication adherence among HIV-infected adults attending a public health clinic. AIDS Patient Care STDS 1: 43-50.
35. Klitzman R, Kirshenbaum SB, Dodge B, Remien RH, Ehrhardt AA, et al. (2004) Intricacies and inter-relationships between HIV disclosure and HAART: A qualitative study. AIDS Care 5: 628-640.
36. Malcolm S, Ng JJ, Rosen RK, Stone VE (2003) An examination of HIV/AIDS patients who have excellent adherence to HAART. AIDS Care 2: 251-261.
37. Meystre-Agustoni G, Dubois-Arber F, Cochand P, Telenti A (2000) Antiretroviral therapies from the patient's perspective. AIDS Care 6: 717-721.
38. Oggins J (2003) Notions of HIV and medication among multiethnic people living with HIV. Health Social Work 1: 53-63.
39. Reback C, Larkins S, Shoptaw S (2003) Methamphetamine abuse as a barrier to HIV medication adherence among gay and bisexual men. AIDS Care 6: 775-785.
40. Ryan G, Wagner GJ (2003) Pill taking 'routinization': A critical factor to understanding episodic medication adherence. AIDS Care 6: 795-806.
41. Wilson H, Hutchinson SA, Holzemer WL (2002) Reconciling incompatibilities: A grounded theory of HIV medication adherence and symptom management. Qual Health Res 10: 1309-1322.
42. Witteveen E, van Ameijden EJC (2002) Drug users and HIV-combination therapy (HAART): Factors with impede or facilitate adherence. Subst Use Misuse 14: 1905-1925.
43. Wood S, Tobias C, McCree J (2004) Medication adherence for HIV positive women caring for children: In their own words. AIDS Care 7: 909-913.
44. Hammami N, Nostlinger C, Hoeree T, Lefevre P, Jonckheer T, et al. (2004) Integrating adherence to highly active antiretroviral therapy into children's daily lives: A qualitative study. Pediatrics 5: e591-e597.
45. Adam B, Maticka-Tyndale E, Cohen JJ (2003) Adherence practices among people living with HIV. AIDS Care 2: 263-274.
46. Aversa S, Kimberlin C (1996) Psychosocial aspects of antiretroviral medication use among HIV patients. Patient Educ Couns 29: 207-219.
47. Brigido L, Rodrigues R, Casseb J, Oliveira D, Rossetti M, et al. (2001) Impact of adherence to antiretroviral therapy in HIV-1-infected patients at a university public service in Brazil. AIDS Patient Care STDS 11: 587-593.
48. Goode M, McMaugh A, Crisp J, Wales S (2003) Adherence issues in children and adolescents receiving highly active antiretroviral therapy. AIDS Care 3: 403-408.
49. Kemppainen J, Levine R, Buffum M, Holzemer W, Finley P, et al. (2004) Antiretroviral adherence in persons with HIV/AIDS and severe mental illness. J Nerv Ment Dis 192: 395-404.
50. Remien R, Hirky AE, Johnson MO, Weinhardt LS, Whittier D, et al. (2003) Adherence to medication treatment: A qualitative study of facilitators and barriers among a diverse sample of HIV+ men and women in four US cities. AIDS Behavior 1: 61-72.
51. Sankar A, Luborsky M, Schuman P, Roberts G (2002) Adherence discourse among African-American women taking HAART. AIDS Care 2: 203-218.
52. Weiser S, Wolfe W, Bangsberg D, Thior I, Gilbert P, et al. (2003) Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr 3: 281-288.
53. Ka'opua L, Mueller CW (2004) Treatment adherence among Native Hawaiians living with HIV. Social Work 1: 55-62.
54. Johnston Roberts K, Mann T (2000) Barriers to antiretroviral medication adherence in HIV-infected women. AIDS Care 4: 377-386.
55. Brook M, Dale A, Tomlinson D, Waterworth C, Daniels D, et al. (2001) Adherence to highly active antiretroviral therapy in the real world: Experience of twelve English HIV units. AIDS Patient Care STDS 9: 491-494.
56. Ammassari A, Murri R, Pezzotti P, Trotta MP, Ravasio L, et al. (2001) Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection. J Acquir Immune Defic Syndr 5: 445-449.
57. Byakika-Tusiime J, Oyugi JH, Tumwikirize WA, Katabira ET, Mugyenyi PN, et al. (2005) Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy. Int J STD AIDS 16: 38-41.
58. Catz S, Kelly JA, Bogart LM, Benotsch EG, McAuliffe TL (2000) Patterns, correlates and barriers to medication adherence among persons prescribed new treatments for HIV disease. Health Psychol 2: 124-133.
59. Chesney M, Ickovics JR, Chambers DB, Gifford AL, Neidig J, et al. (2000) Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG adherence instruments. AIDS Care 3: 255-266.
60. Cupsa A, Ghenonea C, Bulucea D, Dinescu S (2000) Factors with a negative influence on compliance to antiretroviral therapies. Ann N Y Acad Sci 918: 351-354.
61. Eldred L, Wu AW, Chaisson RE, Moore RD (1998) Adherence to antiretroviral and pneumocystis prophylaxis in HIV disease. J Acquir Immune Defic Syndr Hum Retrovirol 2: 117-125.
62. Erlen J, Sereika SM, Cook RL, Hunt SC (2002) Adherence to antiretroviral therapy among women with HIV infection. J Obstet Gynecol Neonatal Nurs 31: 470-477.
63. Fassinou P, Elenga N, Rouet F, Laguide R, Kouakoussui KA, et al. (2004) Highly active antiretroviral therapies among HIV-1 infected children in Abidjan, Cote d'Ivoire. AIDS 18: 1905-1913.
64. Giacomet V, Albano F, Starace F, de Franciscis A, Giaquinto C, et al. (2003) Adherence to antiretroviral therapy and its determinants in children with human immunodeficiency virus infection: A multicenter, national study. Acta Paediatr 92: 1398-1402.
65. Gibb D, Goodall RL, Giacomet V, McGee L, Compagnucci A, et al. (2003) Adherence to prescribed antiretroviral therapy in human immunodeficiency virus-infected children in the PENTA 5 trial. Pediatr Infect Dis J 22: 56-62.
66. Harzke A, Williams ML, Nilsson-Schonnesson L, Ross MW, Timpson S, et al. (2004) Psychosocial factors associated with adherence to antiretroviral medications in a sample of HIV-positive African American drug users. AIDS Care 4: 458-470.
67. Heckman B, Catz SL, Heckman TG, Miller JG, Kalichman SC (2004) Adherence to antiretroviral therapy in rural persons living with HIV disease in the United States. AIDS Care 2: 219-230.
68. Hofer C, Schechter M, Harrison LH (2004) Effectiveness of antiretroviral therapy among patients who attend public HIV clinics in Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr 4: 967-971.
69. Horne R, Buick D, Fisher M, Leake H, Cooper V, et al. (2004) Doubts about necessity and concerns about adverse effects: Identifying the types of beliefs that are associated with non-adherence to HAART. Int J STD AIDS 15: 38-44.
70. Johnson M, Catz SL, Remien RH, Rotheram-Borus MJ, Morin SF, et al. (2003) Theory-guided, empirically supported avenues for intervention on HIV medication nonadherence: Findings from the healthy living project. AIDS Patient Care STDS 12: 645-656.
71. Kalichman S, Catz S, Ramachandran B (1999) Barriers to HIV/AIDS treatment and treatment adherence among African-American adults with disadvantaged education. J Natl Med Assoc 91: 439-446.
72. Kerr T, Palepu A, Barnes G, Walsh J, Hogg R, et al. (1999) Psychosocial determinants of adherence to highly active antiretroviral therapy among injection drug users in Vancouver. Antiviral Ther 9: 407-414.
73. Kleeberger C, Phair JP, Strathdee SA, Detels R, Kingsley L, et al. (2001) Determinants of heterogenous adherence to HIV-antiretroviral therapies in the multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 26: 82-92.
74. Marhefka S, Farley JJ, Rodrigue JR, Sandrik LL, Sleasman JW, et al. (2004) Clinical assessment of medication adherence among HIV-infected children: Examination of the Treatment Interview Protocol (TIP). AIDS Care 3: 323-337.
75. Moatti J, Carrieri MP, Spire B, Gastaut JA, Cassuto JP, et al. (2000) Adherence to HAART in French HIV-infected injecting drug users: The contribution of buprenorphine drug maintenance treatment. AIDS 14: 151-155.
76. Mohammed H, Kieltyka L, Richardson-Alston G, Magnus M, Fawal H, et al. (2004) Adherence to HAART among HIV-infected persons in rural Louisiana. AIDS Patient Care STDS 5: 289-296.
77. Molassiotis A, Nahas-Lopez V, Chung WY, Lam SW, Li CK, et al. (2002) Factors associated with adherence to antiretroviral medication in HIV-infected patients. Int J STD AIDS 13: 301-310.
78. Monreal M, da Cunha RV, Trinca LA (2002) Compliance to antiretroviral medication as reported by AIDS patients assisted at the University Hospital of the Federal University of Mato Grosso do Sul. Braz J Infect Dis 1: 8-14.
79. Mostashari F, Riley E, Selwyn PA, Altice FL (1998) Acceptance and adherence with antiretroviral therapy among HIV-infected women in a correctional facility. J Acquir Immune Defic Syndr Hum Retrovirol 4: 341-348.
80. Muma R, Ross MW, Parcel GS, Pollard RB (1995) Zidovudine adherence among individuals with HIV infection. AIDS Care 4: 439-447.
81. Murphy D, Sarr M, Durako SJ, Moscicki AB, Wilson CM, et al. (2003) Barriers to HAART adherence among human immunodeficiency virus-infected adults. Arch Pediatr Adolesc Med 157: 249-255.
82. Nachega J, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, et al. (2004) Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses 10: 1053-1056.
83. Nieuwkerk P, Sprangers MA, Burger DM, Hoetelmans RM, Hugen PW, et al. (2001) Limited patient adherence to highly active antiretroviral therapy for HIV-1 infection in an observational cohort study. Arch Intern Med 161: 1962-1968.
84. Palmer N, Salcedo J, Miller AL, Winiarski M, Arno P (2003) Psychiatric and social barriers to HIV medication adherence in a triply diagnosed methadone population. AIDS Patient Care STDS 12: 635-644.
85. Pinheiro C, de-Carvalho-Leite JC, Drachler ML, Silveira VL (2002) Factors associated with adherence to antiretroviral therapy in HIV/AIDS patients: A cross-sectional study in Southern Brazil. Braz J Med Biol Res 35: 1173-1181.
86. Reddington C, Cohen J, Baldillo A, Toye M, Smith D, et al. (2000) Adherence to medication regimens among children with human immunodeficiency virus infection. Pediatr Infect Dis J 19: 1148-1153.
87. Reynolds N, Testa MA, Marc LG, Chesney MA, Neidig JL, et al. (2004) Factors influencing medication adherence beliefs and self-efficacy in persons naive to antiretroviral therapy: A multicenter, cross-sectional study. AIDS Behavior 2: 141-150.
88. Savini C, James CW, DiGuglielmo DJ (2003) Survey of patient and clinician attitudes on adherence in a rural HIV clinic. J Assoc Nurses AIDS Care 3: 72-75.
89. Schneider J, Kaplan SH, Greenfield S, Li W, Wilson IB (2004) Better physician-patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection. J Gen Intern Med 19: 1096-1103.
90. Siegel K, Karus D, Schrimshaw EW (2000) Racial differences in attitude toward protease inhibitors among older HIV-infected men. AIDS Care 4: 423-434.
91. Simoni J, Frick PA, Lockhart D, Liebovitz D (2002) Mediators of social support and antiretroviral adherence among an indigent population in New York City. AIDS Patient Care STDS 9: 431-439.
92. Spire B, Duran S, Souville M, Leport C, Raffi F, et al. (2002) Adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients: From a predictive to a dynamic approach. Soc Sci Med 54: 1481-1496.
93. Stein M, Rich JD, Maksad J, Chen MH, Hu P, et al. (2000) Adherence to antiretroviral therapy among HIV-infected methadone patients: Effect of ongoing illicit drug use. Am J Drug Alcohol Abuse 2: 195-205.
94. Stout B, Leon MP, Niccolai LM (2004) Nonadherence to antiretroviral therapy in HIV-positive patients in Costa Rica. AIDS Patient Care STDS 5: 297-304.
95. Tucker JS, Orlando M, Burnam MA, Sherbourne CD, Kung FY, et al. (2004) Psychosocial mediators of antiretroviral nonadherence in HIV-positive adults with substance use and mental health problems. Health Psychol 4: 363-370.
96. van Oosterhout JJ, Bodasing N, Kumwenda JJ, Nyirenda C, Mallewa J, et al. (2005) Evalution of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi. Trop Med Int Health 5: 464-470.
97. Wagner G, Kanouse DE, Koegel P, Sullivan G (2004) Correlates of HIV antiretroviral adherence in persons with serious mental illness. AIDS Care 4: 501-506.
98. Walsh J, Horne R, Dalton M, Burgess AP, Gazzard BG (2001) Reasons for non-adherence to antiretroviral therapy: Patients' perspectives provide evidence of multiple causes. AIDS Care 6: 709-720.
99. Weidle PJ, Ganera CE, Irwin KL, McGowan JP, Ernst JA, et al. (1999) Adherence to antiretroviral medications in an inner city population. J Acquir Immune Defic Syndr 5: 498-502.
100. Wilson TE, Ickovics JR, Fernandez MI, Koenig LJ, Walter E, et al. (2001) Self-reported zidovudine adherence among pregnant women with human immunodeficiency virus infection in four US states. Am J Obstet Gynecol 184: 1235-1240.
101. Mills EJ, Montori VM, Ross CP, Shea B, Wilson K, et al. (2005) Systematically reviewing qualitative studies complements survey design: An exploratory study of barriers to paediatric immunisations. J Clin Epidemiol 11: 1101-1108.
102. Mills E, Wilson K, Rachlis B, Griffith L, Wu P, et al. (2006) Barriers to participation in HIV drug trials: A systematic review. Lancet Infect Dis 1: 32-38.
103. Mills EJ, Seely D, Rachlis B, Griffith L, Wu P, et al. (2006) Barriers to participation in clinical trials of cancer: A meta-analysis and systematic review of patient-reported factors. Lancet Oncol 2: 141-148.
104. Devereaux PJ, Choi PT, El-Dika S, Bhandari M, Montori VM, et al. (2004) An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol 12: 1232-1236.
105. Urquhart J, Vrijens B (2005) New findings about patient adherence to prescribed drug dosing regimens: An introduction to pharmionics. Eur J Hosp Pharm Sci 55: 103-106.
106. Liechty CA, Bangsberg DR (2003) Doubts about DOT: Antiretroviral therapy for resource-poor countries. AIDS 9: 1383-1387.
107. Farmer P, Leandre F, Mukherjee J, Gupta R, Tarter L, et al. (2001) Community-based treatment of advanced HIV disease: Introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull World Health Organ 12: 1145-1151.
108. Johnston-Roberts K, Mann T (2003) Adherence to antiretroviral medications in HIV/AIDS care: A narrative exploration of one woman's foray into intentional nonadherence. Health Care Women Int 24: 552-564