Cancer: NF-κB regulates energy metabolism

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 12, 2012, Pages 2238-2243

  Moretti, Marta ^a   Bennett, Jason ^a   Tornatore, Laura ^a   Thotakura, Anil K ^a   Franzoso, Guido ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Cancer; Glycolysis; Inflammation; NF B; Oxidative metabolism; Respiration

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; ANTINEOPLASTIC AGENT; DEOXYGLUCOSE; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONIDAMINE; METFORMIN; PROTEASOME INHIBITOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREATHING; CANCER COMBINATION CHEMOTHERAPY; CANCER THERAPY; CARCINOGENESIS; DRUG TARGETING; ENERGY METABOLISM; GLYCOLYSIS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOGENESIS; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UNSPECIFIED SIDE EFFECT;

EID: 84866790602     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.08.002     Document Type: Short Survey

References (36)

1. R.G. Baker, M.S. Hayden, and S. Ghosh NF-κB, inflammation, and metabolic disease Cell Metabolism 13 2011 11 22
2. V. Baud, and M. Karin Is NF-kappaB a good target for cancer therapy Nature Reviews Drug Discovery 8 2009 33 40
3. M. De Lena, V. Lorusso, A. Latorre, G. Fanizza, G. Gargano, and L. Caporusso Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study European Journal of Cancer 37 2001 364 368
4. L.F. Dong, R. Freeman, J. Liu, R. Zobalova, A. Marin-Hernandez, and M. Stantic Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II Clinical Cancer Research 15 2009 1593 1600
5. P.J. Goodwin, V. Stambolic, J. Lemieux, B.E. Chen, W.R. Parulekar, and K.A. Gelmon Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents Breast Cancer Research and Treatment 126 2011 215 220
6. F.R. Greten, M.C. Arkan, J. Bollrath, L.C. Hsu, J. Goode, and C. Miething NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta Cell 130 2007 918 931
7. F.R. Greten, L. Eckmann, T.F. Greten, J.M. Park, Z.W. Li, and L.J. Egan IKKβ links inflammation and tumourigenesis in a mouse model of colitis-associated cancer Cell 118 2004 285 296
8. J.Y. Guo, H.Y. Chen, R. Mathew, J. Fan, A.M. Strohecker, and G. Karsli-Uzunbas Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis Genes and Development 25 2011 460 470
9. S. Hadad, T. Iwamoto, L. Jordan, C. Purdie, S. Bray, and L. Baker Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial Breast Cancer Research and Treatment 128 2011 783 789
10. D.M. Hockenbery Targeting mitochondria for cancer therapy Environmental and Molecular Mutagenesis 51 2010 476 489
11. R.F. Johnson, I.I. Witzel, and N.D. Perkins p53-dependent regulation of mitochondrial energy production by the RelA subunit of NF-κB Cancer Research 71 2011 5588 5597
12. R.G. Jones, and C.B. Thompson Tumor suppressor and cell metabolism: a recipe for cancer growth Genes and Development 23 2009 537 548
13. R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, and Y. Xu AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Molecular Cell 18 2005 283 293
14. K. Kawauchi, K. Araki, K. Tobiume, and N. Tanaka p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation Nature Cell Biology 5 2008 611 618
15. K. Kawauchi, K. Araki, K. Tobiume, and N. Tanaka Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification Proceedings of the National Academy of Sciences of the United States of America 106 2009 3431 3436
16. W.H. Koppenol, P.L. Bounds, and C.V. Dang Otto Warburg's contributions to current concepts of cancer metabolism Nature Reviews 11 2011 325 337
17. J.L. Luo, S. Maeda, L.C. Hsu, H. Yagita, and M. Karin Inhibition of NFκB in cancer cells converts inflammation-induced tumour growth mediated by TNFα to TRAIL-mediated tumour regression Cancer Cell 6 2004 297 305
18. B. Martin-Castillo, J. Dorca, A. Vazquez-Martin, C. Oliveras-Ferraros, E. Lopez-Bonet, and M. Garcia Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology Annals of Oncology 21 2010 187 289
19. G. Maschek, N. Savaraj, W. Priebe, P. Braunschweiger, K. Hamilton, and G.F. Tidmarsh 2-Deoxy-d-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo Cancer Research 64 2004 31 34
20. S. Matoba, J.G. Kang, W.D. Patino, A. Wragg, M. Boehm, and O. Gavrilova p53 regulates mitochondrial respiration Science 312 2006 1650 1653
21. C. Mauro, S.C. Leow, E. Anso, S. Rocha, A.K. Thotakura, and L. Tornatore NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration Nature Cell Biology 13 2011 1272 1279
22. D.J. McConkey, and K. Zhu Mechanisms of proteasome inhibitor action and resistance in cancer Drug Resistance Updates 11 2008 164 179
23. P.A. Muller, K.H. Vousden, and J.C. Norman p53 and its mutants in tumour cell migration and invasion Journal of Cell Biology 192 2011 209 218
24. J. Neuzil, J. Cerny, J.C. Dyason, L.F. Dong, and S.J. Ralph Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells Molecular Nutrition & Food Research 55 2011 1543 1551
25. S. Oudard, A. Carpentier, E. Banu, F. Fauchon, D. Celerier, and M.F. Poupon Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme Journal of Neuro-Oncology 63 2003 81 86
26. H. Pelicano Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646
27. J. Quin, D. Engle, A. Litwiller, E. Peralta, A. Grasch, and T. Boley Vitamin E succinate decreases lung cancer tumor growth in mice Journal of Surgical Research 127 2005 139 143
28. S. Rodríguez-Enríquez, A. Marín-Hernández, J.C. Gallardo-Pérez, L. Carreño-Fuentes, and R. Moreno-Sánchez Targeting of cancer energy metabolism Molecular Nutrition & Food Research 53 2009 29 48
29. G. Schneider, A. Henrich, G. Greiner, V. Wolf, A. Lovas, and M. Wieczorek Cross talk between stimulated NF-κB and the tumor suppressor p53 Oncogene 29 2010 2795 2806
30. D. Singh, A.K. Banerji, B.S. Dwarakanath, R.P. Tripathi, J.P. Gupta, and T.L. Mathew Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme Strahlentherapie und Onkologie 18 2005 507 514
31. M.G. Vander-Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
32. K.H. Vousden, and K.M. Ryan p53 and metabolism Nature Reviews Cancer 9 2009 691 700
33. R. Wadhwa, S. Takano, M. Robert, A. Yoshida, H. Nomura, and R.R. Reddel Inactivation of tumor suppressor p53 by Mot-2, a Hsp70 family member Journal of Biological Chemistry 273 1998 29586 29591
34. R. Wadhwa, T. Yaguchi, M.K. Hasan, Y. Mitsui, R.R. Reddel, and S.C. Kaul Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein Experimental Cell Research 274 2002 246 253
35. O. Warburg On the origin of cancer cells Science 123 1956 309 314
36. F. Weinberg, R. Hamanaka, W.W. Wheaton, S. Weinberg, J. Joseph, and M. Lopez Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumourigenicity Proceedings of the National Academy of Sciences of the United States of America 107 2010 8788 8793