CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 12, 2012, Pages 2212-2222

  Liu, Wen Hsin ^a   Chen, Yeh Long ^b   Chang, Long Sen ^a,b  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

CIL 102; Genetic transcription; MMP 2 MMP 9; mRNA stability

Indexed keywords

1 [4 (FURO[2,3 B]QUINOLIN 4 YLAMINO)PHENYL]ETHANONE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; CIL 102; GELATINASE A; GELATINASE B; JANUS KINASE; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN PHOSPHATASE 2A; TRISTETRAPROLIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIVER CANCER; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN STABILITY; RNA STABILITY;

ANTINEOPLASTIC AGENTS; CALCIUM SIGNALING; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HUMANS; LUCIFERASES, RENILLA; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PROTEIN PHOSPHATASE 2; QUINOLINES; REACTIVE OXYGEN SPECIES; RNA STABILITY; TRANSCRIPTION, GENETIC; TRISTETRAPROLIN;

EID: 84866778284     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.08.021     Document Type: Article

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