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Volumn 7, Issue , 2012, Pages 1723-1735

Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidonecoated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS

Author keywords

LC MS MS; Metabolites; NCTD; Pharmacokinetics; PVP

Indexed keywords

CHITOSAN; NANOCOATING; NANOPARTICLE; NORCANTHARIDIN; POVIDONE; TRIPOLYPHOSPHATE; FUSED HETEROCYCLIC RINGS;

EID: 84866753291     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S29696     Document Type: Article
Times cited : (28)

References (33)
  • 1
    • 0024428817 scopus 로고
    • Medical uses of mylabris in ancient China and recent studies
    • Wang GS. Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol. 1989;26(2):147-162.
    • (1989) J Ethnopharmacol. , vol.26 , Issue.2 , pp. 147-162
    • Wang, G.S.1
  • 3
    • 0029034492 scopus 로고
    • Effects of norcantharidin, a protein phosphatase type-2 A inhibitor, on the growth of normal and malignant haemopoietic cells
    • Liu XH, Blazsek I, Comisso M, et al. Effects of norcantharidin, a protein phosphatase type-2 A inhibitor, on the growth of normal and malignant haemopoietic cells. Eur J Cancer. 1995;31(6):953-963.
    • (1995) Eur J Cancer. , vol.31 , Issue.6 , pp. 953-963
    • Liu, X.H.1    Blazsek, I.2    Comisso, M.3
  • 4
    • 64749109218 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) nanoparticles as carriers for norcantharidin
    • Zeng QB, Sun M. Poly(lactide-co-glycolide) nanoparticles as carriers for norcantharidin. Mater Sci Eng C. 2009;29(3):708-713.
    • (2009) Mater Sci Eng C. , vol.29 , Issue.3 , pp. 708-713
    • Zeng, Q.B.1    Sun, M.2
  • 5
    • 34447635904 scopus 로고    scopus 로고
    • Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation
    • Hill TA, Stewart SG, Ackland SP, et al. Norcantharimides, synthesis and anticancer activity: synthesis of new norcantharidin analogues and their anticancer evaluation. Bioorg Med Chem. 2007;15(18): 6126-6134.
    • (2007) Bioorg Med Chem. , vol.15 , Issue.18 , pp. 6126-6134
    • Hill, T.A.1    Stewart, S.G.2    Ackland, S.P.3
  • 6
    • 33748685215 scopus 로고    scopus 로고
    • A less irritant norcantharidin lipid microspheres: Formulation and drug distribution
    • Wang LX, He HB, Tang X, Shao RY, Chen DW. A less irritant norcantharidin lipid microspheres: formulation and drug distribution. Int J Pharm. 2006;323:161-167.
    • (2006) Int J Pharm. , vol.323 , pp. 161-167
    • Wang, L.X.1    He, H.B.2    Tang, X.3    Shao, R.Y.4    Chen, D.W.5
  • 7
    • 67651227161 scopus 로고    scopus 로고
    • Application of targeted drug delivery system in Chinese medicine
    • Li DC, Zhong XK, Zeng ZP, Jiang JG, et al. Application of targeted drug delivery system in Chinese medicine. J Control Release. 2009;138(2): 103-112.
    • (2009) J Control Release. , vol.138 , Issue.2 , pp. 103-112
    • Li, D.C.1    Zhong, X.K.2    Zeng, Z.P.3    Jiang, J.G.4
  • 8
    • 79951675295 scopus 로고    scopus 로고
    • In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles
    • Zheng H, Zhang XQ, Yin YH, et al. In vitro characterization, and in vivo studies of crosslinked lactosaminated carboxymethyl chitosan nanoparticles. Carbohydr Polym. 2011;84(3):1048-1053.
    • (2011) Carbohydr Polym. , vol.84 , Issue.3 , pp. 1048-1053
    • Zheng, H.1    Zhang, X.Q.2    Yin, Y.H.3
  • 9
    • 33751224468 scopus 로고    scopus 로고
    • Novel polymeric microspheres containing norcantharidin for chemoembolization
    • Liu XH, Heng WS, Paul, LQ, Chan LW. Novel polymeric microspheres containing norcantharidin for chemoembolization. J Control Release. 2006;116:35-41.
    • (2006) J Control Release. , vol.116 , pp. 35-41
    • Liu, X.H.1    Heng, W.S.2    Paul, L.Q.3    Chan, L.W.4
  • 10
    • 0035936972 scopus 로고    scopus 로고
    • Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency
    • Mao HQ, Roy KN, Troung-Le VL, et al. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release. 2001;70(3):399-421.
    • (2001) J Control Release. , vol.70 , Issue.3 , pp. 399-421
    • Mao, H.Q.1    Roy, K.N.2    Troung-le, V.L.3
  • 11
    • 77249111686 scopus 로고    scopus 로고
    • The safety of chitosan as a pharmaceutical excipient
    • Baldrick P. The safety of chitosan as a pharmaceutical excipient. Regul Toxicol Pharm. 2010;56(3):290-299.
    • (2010) Regul Toxicol Pharm. , vol.56 , Issue.3 , pp. 290-299
    • Baldrick, P.1
  • 12
    • 79952444444 scopus 로고    scopus 로고
    • Effect of PVP-coated silver nanoparticles using laser direct patterning process by photothermal effect
    • Cheng YT, Uang RH, Chiou KC. Effect of PVP-coated silver nanoparticles using laser direct patterning process by photothermal effect. Microelectron Eng. 2011;88(6):929-934.
    • (2011) Microelectron Eng. , vol.88 , Issue.6 , pp. 929-934
    • Cheng, Y.T.1    Uang, R.H.2    Chiou, K.C.3
  • 13
    • 33847661478 scopus 로고    scopus 로고
    • 3O4 nanoparticles for biomedical applications
    • 3O4 nanoparticles for biomedical applications. J Magn Magn Mater. 2007;310(2):e815-e817.
    • (2007) J Magn Magn Mater. , vol.310 , Issue.2
    • Liu, H.L.1    Ko, S.P.2    Wu, J.H.3
  • 14
    • 77955417131 scopus 로고    scopus 로고
    • Gas chromatography/mass spectrometry (GC/MS) remains a preeminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry(LC/MS/MS)
    • Krone N, Hughes BA, Lavery GG, Stewart PM, Arlt W, Shackleton CH. Gas chromatography/mass spectrometry (GC/MS) remains a preeminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry(LC/MS/MS). J Steroid Biochem Mol Biol. 2010;121:496-504.
    • (2010) J Steroid Biochem Mol Biol. , vol.121 , pp. 496-504
    • Krone, N.1    Hughes, B.A.2    Lavery, G.G.3    Stewart, P.M.4    Arlt, W.5    Shackleton, C.H.6
  • 15
    • 11144317888 scopus 로고    scopus 로고
    • Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods
    • Zhang JL, Cui M, He Y, Yu HL, Guo DA. Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods. J Pharm Biomed Anal. 2005;36(5): 1029-1035.
    • (2005) J Pharm Biomed Anal. , vol.36 , Issue.5 , pp. 1029-1035
    • Zhang, J.L.1    Cui, M.2    He, Y.3    Yu, H.L.4    Guo, D.A.5
  • 16
    • 0036470424 scopus 로고    scopus 로고
    • Complete sequencing of anti-vancomycin fab fragment by liquid chromatography-electrospray ion trap mass spectrometry with a combination of database searching and manual interpretation of the MS/MS spectra
    • Adamczyk M, Gebler JC, Wu J, Yu ZG. Complete sequencing of anti-vancomycin fab fragment by liquid chromatography-electrospray ion trap mass spectrometry with a combination of database searching and manual interpretation of the MS/MS spectra. J Immunol Meth. 2002;260:235-249.
    • (2002) J Immunol Meth. , vol.260 , pp. 235-249
    • Adamczyk, M.1    Gebler, J.C.2    Wu, J.3    Yu, Z.G.4
  • 17
    • 42649083309 scopus 로고    scopus 로고
    • High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
    • Cui L, Chan W, Wu JL, Jiang ZH, Chan K, Cai ZW. High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen. Talanta. 2008;75:1002-1007.
    • (2008) Talanta. , vol.75 , pp. 1002-1007
    • Cui, L.1    Chan, W.2    Wu, J.L.3    Jiang, Z.H.4    Chan, K.5    Cai, Z.W.6
  • 18
    • 38349137338 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of lithospermic acid by LC-MS/MS in rats
    • Wang L, Zhang Q, Li XC, et al. Pharmacokinetics and metabolism of lithospermic acid by LC-MS/MS in rats. Int J Pharm. 2008;350: 240-246.
    • (2008) Int J Pharm. , vol.350 , pp. 240-246
    • Wang, L.1    Zhang, Q.2    Li, X.C.3
  • 19
    • 0030779190 scopus 로고    scopus 로고
    • Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines
    • Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997;14:1431-1436.
    • (1997) Pharm Res. , vol.14 , pp. 1431-1436
    • Calvo, P.1    Remunan-Lopez, C.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 20
    • 77949916194 scopus 로고    scopus 로고
    • Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery
    • Wang Q, Zhang L, Hu W, et al. Norcantharidin-associated galactosylated chitosan nanoparticles for hepatocyte-targeted delivery. Nanomed Nanotechnol Biol Med. 2010;6:371-381.
    • (2010) Nanomed Nanotechnol Biol Med. , vol.6 , pp. 371-381
    • Wang, Q.1    Zhang, L.2    Hu, W.3
  • 21
    • 77954287550 scopus 로고    scopus 로고
    • Two modelling data analytical methods applied to optimise the preparation of norcantharidin chitosan nanoparticles
    • Zhang W, Liu Y, Chen XY, et al. Two modelling data analytical methods applied to optimise the preparation of norcantharidin chitosan nanoparticles. J Exp Nanosci. 2010;5(3):271-284.
    • (2010) J Exp Nanosci. , vol.5 , Issue.3 , pp. 271-284
    • Zhang, W.1    Liu, Y.2    Chen, X.Y.3
  • 22
    • 79953084395 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice
    • Gannon SA, Johnson T, Nabb DL, Serex TL, Buck RC, Loveless SE. Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice. Toxicology. 2011;283:55-62.
    • (2011) Toxicology. , vol.283 , pp. 55-62
    • Gannon, S.A.1    Johnson, T.2    Nabb, D.L.3    Serex, T.L.4    Buck, R.C.5    Loveless, S.E.6
  • 23
    • 0034608989 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution, and metabolism of flumequine in channel catfish (Ictalurus punctatus)
    • Plakas SM, Said KR, Musser SM. Pharmacokinetics, tissue distribution, and metabolism of flumequine in channel catfish (Ictalurus punctatus). Aquaculture. 2000;187:1-14.
    • (2000) Aquaculture. , vol.187 , pp. 1-14
    • Plakas, S.M.1    Said, K.R.2    Musser, S.M.3
  • 24
    • 77649236913 scopus 로고    scopus 로고
    • Chitosan filler effects on the experimental characterization, spectroscopic investigation and thermal studies of PVA/PVP blend films
    • Abdelrazek EM, Elashmawi IS, Labeeb S. Chitosan filler effects on the experimental characterization, spectroscopic investigation and thermal studies of PVA/PVP blend films. Physica B. 2010;405(8): 2021-2027.
    • (2010) Physica B. , vol.405 , Issue.8 , pp. 2021-2027
    • Abdelrazek, E.M.1    Elashmawi, I.S.2    Labeeb, S.3
  • 25
    • 33750311400 scopus 로고    scopus 로고
    • 2 submicron particles via microwave irradiation
    • 2 submicron particles via microwave irradiation. Mater Lett. 2006;60: 3714-3717.
    • (2006) Mater Lett. , vol.60 , pp. 3714-3717
    • Yang, H.M.1    Huang, C.H.2    Su, X.H.3
  • 26
    • 10644232971 scopus 로고    scopus 로고
    • Studies on the liver targeting of norcantharindin microemulsion
    • Zhang L, Xiang D, Zheng H, Zhang ZR. Studies on the liver targeting of norcantharindin microemulsion. Acta Pharmaceutica Sinica. 2004;39(8):650-655.
    • (2004) Acta Pharmaceutica Sinica. , vol.39 , Issue.8 , pp. 650-655
    • Zhang, L.1    Xiang, D.2    Zheng, H.3    Zhang, Z.R.4
  • 27
    • 68449098284 scopus 로고    scopus 로고
    • Pharmacokinetics of norcantharidin in human by urinary excretion method
    • Wei CM, Wang BJ, Yuan GY. Pharmacokinetics of norcantharidin in human by urinary excretion method. Chin Pharm J. 2009;44: 1019-1021.
    • (2009) Chin Pharm J. , vol.44 , pp. 1019-1021
    • Wei, C.M.1    Wang, B.J.2    Yuan, G.Y.3
  • 28
    • 77950933847 scopus 로고    scopus 로고
    • Analysis of cyclosporine A and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry
    • Fang ZG, You BG, Chen YG, et al. Analysis of cyclosporine A and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry. J Chromatogr B. 2010;878:1153-1162.
    • (2010) J Chromatogr B. , vol.878 , pp. 1153-1162
    • Fang, Z.G.1    You, B.G.2    Chen, Y.G.3
  • 29
    • 79957843199 scopus 로고    scopus 로고
    • Separation and identification of norcantharidin metabolites in vivo by GC-method
    • Wei CM, Teng YN, Wang BJ, et al. Separation and identification of norcantharidin metabolites in vivo by GC-method. J Chromatogr B. 2011;879:1741-1747.
    • (2011) J Chromatogr B. , vol.879 , pp. 1741-1747
    • Wei, C.M.1    Teng, Y.N.2    Wang, B.J.3
  • 31
    • 21744446564 scopus 로고    scopus 로고
    • Preparation of nanoparticles composed of poly (s-glutamic acid)-poly (lactide) block copolymers and evaluation of their uptake by HepG2 cells
    • Liang HF, Yang TF, Huang CT, Chen MC, Sung HW. Preparation of nanoparticles composed of poly (s-glutamic acid)-poly (lactide) block copolymers and evaluation of their uptake by HepG2 cells. J Control Release. 2005;105:213-225.
    • (2005) J Control Release. , vol.105 , pp. 213-225
    • Liang, H.F.1    Yang, T.F.2    Huang, C.T.3    Chen, M.C.4    Sung, H.W.5
  • 32
    • 3042697876 scopus 로고    scopus 로고
    • 177 Polycationic liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice
    • Wu J, Liu L, Yen RD, Le HT, et al. 177 Polycationic liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology. 2004;40:195-204.
    • (2004) Hepatology. , vol.40 , pp. 195-204
    • Wu, J.1    Liu, L.2    Yen, R.D.3    Le, H.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.