Separation and identification of norcantharidin metabolites in vivo by GC-MS method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 20, 2011, Pages 1741-1747

  Wei, Chunmin ^a,b   Teng, Yanni ^a   Wang, Benjie ^a   Zhang, Xiumei ^b   Yuan, Guiyan ^a   Liu, Xiaoyan ^a   Li, Rong ^a   Guo, Ruichen ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Derivate; GC MS; Metabolism; Metabolites; Norcantharidin

Indexed keywords

BIOLOGICAL SAMPLES; CANTHARIDIN; CARBONYL GROUPS; CHROMATOGRAM COMPARISON; DERIVATE; FIVE PHASE; FRAGMENTATION PATTERNS; GC-MS; HUMAN CANCER; HUMAN TUMOR CELLS; HYDROLYZED PRODUCTS; IN-VIVO; NORCANTHARIDIN; PHASE II; SEPARATION AND IDENTIFICATION; SIDE EFFECT;

BIOMOLECULES; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; DRUG INTERACTIONS; METABOLITES; PHYSIOLOGY;

METABOLISM;

(1,2,3,4) 7 OXABICYCLO[2,2,1]HEPTANE 2,3 DICARBOXYLIC ACID; 2,3 BIS(HYDROXYMETHYL)SUCCINIC ACID; 3,4 FURANDICARBOXYLIC ACID; 3,6 DIHYDROXYCYCLOHEXANE 1,2 DICARBOXYLIC ACID; 3,6 DIMETHOXY 4,5 DIMETHYLCYCLO HEXANE 1,2 DICARBOXYLIC ACID; CARBONYL DERIVATIVE; DRUG METABOLITE; HYDROXYL GROUP; NORCANTHARIDIN; NORCANTHARIDIN GLUCURONIC ACID CONJUGATE; NORCANTHARIDIN GLUTATHIONE CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG STRUCTURE; IN VIVO STUDY; MASS FRAGMENTOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BILE; DRUGS, CHINESE HERBAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 79957843199     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.04.019     Document Type: Article

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