Structural and functional neural correlates of visuospatial information processing in normal aging and amnestic mild cognitive impairment

Neurobiology of Aging

Volumn 33, Issue 12, 2012, Pages 2782-2797

  Alichniewicz, Karolina K ^a   Brunner, Florian ^a   Klünemann, Hans H ^a   Greenlee, Mark W ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Aging; Alzheimer's disease; Apolipoprotein E; Functional magnetic resonance imaging; Mild cognitive impairment; Working memory

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; AGED; AGING; ARTICLE; BRAIN REGION; COMPARATIVE ANATOMY; CONTROLLED STUDY; DEPTH PERCEPTION; DISEASE ASSOCIATION; FEMALE; FUNCTIONAL ASSESSMENT; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE FRONTAL GYRUS; MILD COGNITIVE IMPAIRMENT; OCCIPITAL GYRUS; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; RISK FACTOR; SUPERIOR FRONTAL GYRUS; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGING; ANALYSIS OF VARIANCE; ATTENTION; BRAIN; BRAIN MAPPING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PHOTIC STIMULATION; REACTION TIME; SPACE PERCEPTION; YOUNG ADULT;

EID: 84866747081     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.02.010     Document Type: Article

References (125)

1. Adamson M.M., Landy K.M., Duong S., Fox-Bosetti S., Ashford J.W., Murphy G.M., Weiner M., Taylor J.L. Apolipoprotein E ε4 influences on episodic recall and brain structures in aging pilots. Neurobiol. Aging 2010, 31:1059-1063.
2. Alescio-Lautier B., Michel B.F., Herrera C., Elahmadi A., Chambon C., Touzet C., Paban V. Visual and visuospatial short-term memory in mild cognitive impairment and Alzheimer disease: Role of attention. Neuropsychologia 2007, 45:1948-1960.
3. Artero S., Petersen R., Touchon J., Ritchie K. Revised criteria for mild cognitive impairment: validation within a longitudinal population study. Dement. Ger. Cogn. Disord 2006, 22:465-470.
4. Ashburner J., Friston K.J. Voxel-based morphometry-the methods. NeuroImage 2000, 11:805-821.
5. Baddeley A. Working memory: looking back and looking forward. Nat. Rev. Neurosci 2003, 4:829-839.
6. Baddeley A. Working memory. Curr. Biol 2010, 20:R136-R140.
7. Baddeley A.D., Bressi S., Della Sala S., Logie R., Spinnler H. The decline of working memory in Alzheimer's disease. A longitudinal study. Brain 1991, 114:2521-2542.
8. Baddeley A.D., Hitch G. Working memory. The psychology of learning and motivation: advances in research and theory 1974, Volume 8:47-89. Academic Press, New York.
9. Baltes M.M., Carstensen L.L. The process of successful ageing. Ageing & Society 1996, 16:397-422.
10. Bandaru V.V., Troncoso J., Wheeler D., Pletnikova O., Wang J., Conant K., Haughey N.J. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiol. Aging 2009, 30:591-599.
11. Barth S., Schönknecht P., Pantel J., Schröder J. [Mild cognitive impairment and Alzheimer's disease: an investigation of the CERAD-NP test battery]. Fortschritte der Neurologie-Psychiatrie, Neuropsychologische Profile in der Demenzdiagnostik: Eine Untersuchung mit der CERAD-NP-Testbatterie 2005, 73:568-576.
12. Belleville S., Chertkow H., Gauthier S. Working memory and control of attention in persons with alzheimer's disease and mild cognitive impairment. Neuropsychology 2007, 21:458-469.
13. Berman R.A., Colby C.L. Spatial working memory in human extrastriate cortex. Physiol. Behav 2002, 77:621-627.
14. Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet 2007, 39:17-23.
15. Bertram L., Tanzi R.E. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat. Rev. Neurosci 2008, 9:768-778.
16. Bertram L., Tanzi R.E. Genome-wide association studies in Alzheimer's disease. Hum. Mol. Genet 2009, 18:R137-R145.
17. Bishop N.A., Lu T., Yankner B.A. Neural mechanisms of ageing and cognitive decline. Nature 2010, 464:529-535.
18. Bledowski C., Rahm B., Rowe J.B. What "works" in working memory?. separate systems for selection and updating of critical information. J. Neurosci 2009, 29:13735-13741.
19. Blennow K., Bogdanovic N., Alafuzoff I., Ekman R., Davidsson P. Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele. J. Neural Transm 1996, 103:603-618.
20. Bokde A.L.W., Lopez-Bayo P., Born C., Dong W., Meindl T., Leinsinger G., Teipel S.J., Faltraco F., Reiser M., Möller H.-J., Hampel H. Functional abnormalities of the visual processing system in subjects with mild cognitive impairment: an fMRI study. Psychiatry Res. Neuroimaging 2008, 163:248-259.
21. Bosch B., Bartrés-Faz D., Rami L., Arenaza-Urquijo E.M., Fernández-Espejo D., Junqué C., Solé-Padullés C., Sánchez-Valle R., Bargalló N., Falcón C., Molinuevo J.L. Cognitive reserve modulates task-induced activations and deactivations in healthy elders, amnestic mild cognitive impairment and mild Alzheimer's disease. Cortex 2010, 46:451-461.
22. Cabeza R., Daselaar S.M., Dolcos F., Prince S.E., Budde M., Nyberg L. Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. Cereb. Cortex 2004, 14:364-375.
23. Caine D., Hodges J.R. Heterogeneity of semantic and visuospatial deficits in early Alzheimer's disease. Neuropsychology 2001, 15(2):155-164.
24. Carlson S., Martinkauppi S., Rämä P., Salli E., Korvenoja A., Aronen H.J. Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging. Cereb. Cortex 1998, 8:743-752.
25. Cherbuin N., Anstey K.J., Sachdev P.S., Maller J.J., Meslin C., Mack H.A., Wen W., Easteal S. Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals. J. Gerontol. A Biol. Sci. Med. Sci 2008, 63:501-504.
26. Chertkow H., Massoud F., Nasreddine Z., Belleville S., Joanette Y., Bocti C., Drolet V., Kirk J., Freedman M., Bergman H. Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. CMAJ 2008, 178:1273-1285.
27. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., Roses A.D., Haines J.L., Pericak-Vance M.A. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993, 261:921-923.
28. Corey-Bloom J., Tiraboschi P., Hansen L.A., Alford M., Schoos B., Sabbagh M.N., Masliah E., Thal L.J. E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease. Neurology 2000, 54:403-406.
29. Cornoldi C., Bassani C., Berto R., Mammarella N. Aging and the intrusion superiority effect in visuo-spatial working memory. Aging Neuropsychol. Cogn 2007, 14:1-21.
30. Courchesne E., Chisum H.J., Townsend J., Cowles A., Covington J., Egaas B., Harwood M., Hinds S., Press G.A. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 2000, 216:672-682.
31. Devanand D.P., Pelton G.H., Zamora D., Liu X., Tabert M.H., Goodkind M., Scarmeas N., Braun I., Stern Y., Mayeux R. Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment. Arch. Neurol 2005, 62:975-980.
32. Dickerson B.C., Sperling R.A., Hyman B.T., Albert M.S., Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Arch. Gen. Psychiatry 2007, 64:1443-1450.
33. Dubois B., Feldman H.H., Jacova C., DeKosky S.T., Barberger-Gateau P., Cummings J., Delacourte A., Galasko D., Gauthier S., Jicha G., Meguro K., O'Brien J., Pasquier F., Robert P., Rossor M., Salloway S., Stern Y., Visser P.J., Scheltens P. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007, 6:734-746.
34. Economou A., Papageorgiou S.G., Karageorgiou C., Vassilopoulos D. Nonepisodic memory deficits in amnestic MCI. Cogn. Behav. Neurol 2007, 20:99-106.
35. Égerházi A., Berecz R., Bartók E., Degrell I. Automated neuropsychological test battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:746-751.
36. Ehrensperger M.M., Berres M., Taylor K.I., Monsch A.U. Early detection of Alzheimer's disease with a total score of the German CERAD. J. Int. Neuropsychol. Soc 2010, 16:910-920.
37. Fjell A.M., Walhovd K.B. Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci 2010, 21:187-222.
38. Foster N.L., Chase T.N., Fedio P., Patronas N.J., Brooks R.A., Di Chiro G. Alzheimer's disease: focal cortical changes shown by positron emission tomography. Neurology 1983, 33:961-965.
39. Fox N.C., Warrington E.K., Seiffer A.L., Agnew S.K., Rossor M.N. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study. Brain 1998, 121:1631-1639.
40. Frank G., Hennig-Fast K., Klünemann H.H., Schmitz G., Greenlee M.W. Differential impact of ApoE ε4 on cortical activation during famous face recognition in cognitively intact individuals and patients with amnestic mild cognitive impairment. Alzheimer Dis. Assoc. Disord 2011, 25:250-261.
41. Freund A.M. Successful aging as management of resources: the role of selection, optimization, and compensation. Res. Hum. Dev 2008, 5:94-106.
42. Freund A.M., Baltes P.B. Selection, optimization, and compensation as strategies of life management: correlations with subjective indicators of successful aging. Psychol. Aging 1998, 13:531-543.
43. Frisoni G.B., Pievani M., Testa C., Sabattoli F., Bresciani L., Bonetti M., Beltramello A., Hayashi K.M., Toga A.W., Thompson P.M. The topography of grey matter involvement in early and late onset Alzheimer's disease. Brain 2007, 130:720-730.
44. Friston K.J., Holmes A.P., Worsley K.J., Poline J.-P., Frith C.D., Frackowiak R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp 1994, 2:189-210.
45. Good C.D., Johnsrude I.S., Ashburner J., Henson R.N., Friston K.J., Frackowiak R.S. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 2001, 14:21-36.
46. Greicius M.D., Srivastava G., Reiss A.L., Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:4637-4642.
47. Grieve S.M., Clark C.R., Williams L.M., Peduto A.J., Gordon E. Preservation of limbic and paralimbic structures in aging. Hum. Brain Mapp 2005, 25:391-401.
48. Hämäläinen A., Grau-Olivares M., Tervo S., Niskanen E., Pennanen C., Huuskonen J., Kivipelto M., Hänninen T., Tapiola M., Vanhanen M., Hallikainen M., Helkala E.L., Nissinen A., Vanninen R.L., Soininen H. Apolipoprotein E epsilon 4 allele is associated with increased atrophy in progressive mild cognitive impairment: a voxel-based morphometric study. Neurodegener. Dis 2008, 5:186-189.
49. Hardt J., Gerbershagen H.U., Franke P. The symptom check-list, SCL-90-R: its use and characteristics in chronic pain patients. Eur. J. Pain 2000, 4:137-148.
50. Haug H., Eggers R. Morphometry of the human cortex cerebri and corpus striatum during aging. Neurobiol. Aging 1991, 12:336-338.
51. Haxby J.V., Duara R., Grady C.L., Cutler N.R., Rapoport S.I. Relations between neuropsychological and cerebral metabolic asymmetries in early Alzheimer's disease. J. Cerebral Blood Flow Metab 1985, 5:193-200.
52. Hedden T., Gabrieli J.D. Insights into the ageing mind: a view from cognitive neuroscience. Nat. Rev. Neurosci 2004, 5:87-96.
53. Hindmarch I., Lehfeld H., de Jongh P., Erzigkeit H. The Bayer Activities of Daily Living Scale (B-ADL). Dement. Geriatr. Cogn. Disord 1998, 9(suppl 2):20-26.
54. Iachini T., Iavarone A., Senese V.P., Ruotolo F., Ruggiero G. Visuospatial memory in healthy elderly, AD and MCI: a review. Curr. Aging Sci 2009, 2:43-59.
55. Jack C.R., Albert M.S., Knopman D.S., McKhann G.M., Sperling R.A., Carrillo M.C., Thies B., Phelps C.H. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:257-262.
56. Johnson D.K., Storandt M., Morris J.C., Galvin J.E. Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch. Neurol 2009, 66:1254-1259.
57. Johnson S.C., Saykin A.J., Baxter L.C., Flashman L.A., Santulli R.B., McAllister T.W., Mamourian A.C. The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and Alzheimer disease. NeuroImage 2000, 11:179-187.
58. Kalpouzos G., Chételat G., Baron J.C., Landeau B., Mevel K., Godeau C., Barré L., Constans J.M., Viader F., Eustache F., Desgranges B. Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging. Neurobiol. Aging 2009, 30:112-124.
59. Kamboh M.I., Minster R.L., Kenney M., Ozturk A., Desai P.P., Kammerer C.M., DeKosky S.T. Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease. Neurobiol. Aging 2006, 27:1435-1439.
60. Karas G.B., Scheltens P., Rombouts S.A., Visser P.J., van Schijndel R.A., Fox N.C., Barkhof F. Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. NeuroImage 2004, 23:708-716.
61. Kemps E., Newson R. Comparison of adult age differences in verbal and visuo-spatial memory: the importance of "pure", parallel and validated measures. J. Clin. Exp. Neuropsychol 2006, 28:341-356.
62. Kensinger E.A., Shearer D.K., Locascio J.J., Growdon J.H., Corkin S. Working memory in mild Alzheimer's disease and early Parkinson's disease. Neuropsychology 2003, 17:230-239.
63. Kim S., Swaminathan S., Shen L., Risacher S.L., Nho K., Foroud T., Shaw L.M., Trojanowski J.Q., Potkin S.G., Huentelman M.J., Craig D.W., DeChairo B.M., Aisen P.S., Petersen R.C., Weiner M.W., Saykin A.J. Genome-wide association study of CSF biomarkers Aβ1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology 2011, 76:69-79. Alzheimer's Disease Neuroimaging Initiative.
64. Kochan N.A., Breakspear M., Slavin M.J., Valenzuela M., McCraw S., Brodaty H., Sachdev P.S. Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge. Dement. Geriatr. Cogn. Disord 2010, 30:553-568.
65. Kühner C., Bürger C., Keller F., Hautzinger M. Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples [in German]. Nervenarzt 2007, 78:651-656.
66. LaBar K.S., Gitelman D.R., Parrish T.B., Mesulam M. Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects. NeuroImage 1999, 10:695-704.
67. Lahiri D.K., Sambamurti K., Bennett D.A. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Neurobiol. Aging 2004, 25:651-660.
68. Lee C.-U., Lim H.-K. Altered visuospatial working memory process in patients with Alzheimer's disease: fMRI investigation. Alzheimers Dement 2010, 6. S285-S285.
69. Lemaître H., Crivello F., Dufouil C., Grassiot B., Tzourio C., Alpérovitch A., Mazoyer B. No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects. NeuroImage 2005, 24:1205-1213.
70. Lopez O.L., Becker J.T., Jagust W.J., Fitzpatrick A., Carlson M.C., DeKosky S.T., Breitner J., Lyketsos C.G., Jones B., Kawas C., Kuller L.H. Neuropsychological characteristics of mild cognitive impairment subgroups. J. Neurol. Neurosurg. Psychiatry 2006, 77:159-165.
71. Maldjian J.A., Laurienti P.J., Kraft R.A., Burdette J.H. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 2003, 19:1233-1239.
72. Marquis S., Moore M.M., Howieson D.B., Sexton G., Payami H., Kaye J.A., Camicioli R. Independent predictors of cognitive decline in healthy elderly persons. Arch. Neurol 2002, 59:601-606.
73. Martin A., Brouwers P., Lalonde F., Cox C., Teleska P., Fedio P., Foster N.L., et al. Towards a behavioral typology of Alzheimer's patients. J. Clin. Exp. Neuropsychology 1986, 8:594-610.
74. McGuinness B., Barrett S.L., Craig D., Lawson J., Passmore A.P. Executive functioning in Alzheimer's disease and vascular dementia. Int. J. Geriatr. Psychiatry 2010, 25:562-568.
75. Mesulam M.M., Nobre A.C., Kim Y.H., Parrish T.B., Gitelman D.R. Heterogeneity of cingulate contributions to spatial attention. NeuroImage 2001, 13(6 Pt 1):1065-1072. 10.1006/nimg.2001.0768.
76. Michels L., Moazami-Goudarzi M., Jeanmonod D., Sarnthein J. EEG alpha distinguishes between cuneal and precuneal activation in working memory. NeuroImage 2008, 40:1296-1310.
77. Morris J.C. Clinical Dementia Rating: a reliable and valid diagnostic and staging measure for dementia of the alzheimer type. Int. Psychogeriatr. 1997, 9(Suppl):173-176.
78. Nagel I.E., Preuschhof C., Li S.C., Nyberg L., Bäckman L., Lindenberger U., Heekeren H.R. Performance level modulates adult age differences in brain activation during spatial working memory. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:22552-22557.
79. Nestor P.J., Caine D., Fryer T.D., Clarke J., Hodges J.R. The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET. Journal Of Neurology Neurosurgery And Psychiatry 2003, 74(11):1521-1529.
80. Nickl-Jockschat T., Kleiman A., Schulz J., Schneider F., Laird A., Fox P., Eickhoff S., Reetz K. Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: a meta-analysis. Brain Struct. Funct 2012, 217:115-125.
81. Ouwehand C., de Ridder D.T.D., Bensing J.M. A review of successful aging models: proposing proactive coping as an important additional strategy. Clin. Psychol. Review 2007, 27:873-884.
82. Owen A.M., McMillan K.M., Laird A.R., Bullmore E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp 2005, 25:46-59.
83. Parasuraman R., Greenwood P.M., Sunderland T. The Apolipoprotein E gene, attention, and brain function. Neuropsychology 2002, 16:254-274.
84. Patalong-Ogiewa M.B., Siuda J.S., Opala G.M. Working and episodic memory in the MCI group. J. Neurol. Sci 2009, 283. 291-291.
85. Petersen R. Mild cognitive impairment as a diagnostic entity. J. Intern. Med 2004, 256:183-194.
86. Petersen R.C. The current status of mild cognitive impairment-what do we tell our patients?. Nat. Clin. Pract. Neurol 2007, 3:60-61.
87. Petersen R.C., Jack C.R. Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment. Clin. Pharmacol. Ther 2009, 86:438-441.
88. Postle B.R., D'Esposito M. "What"-Then-Where" in visual working memory: an event-related fMRI study. J. Cogn. Neurosci 1999, 11:585-597.
89. Prvulovic D., Van de Ven V., Sack A.T., Maurer K., Linden D.E.J. Functional activation imaging in aging and dementia. Psychiatry Res. Neuroimaging 2005, 140:97-113.
90. Raber J., Huang Y., Ashford J.W. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol. Aging 2004, 25:641-650.
91. Raczkowski D., Kalat J.W., Nebes R. Reliability and validity of some handedness questionnaire items. Neuropsychologia 1974, 12:43-47.
92. Raz N., Lindenberger U., Rodrigue K.M., Kennedy K.M., Head D., Williamson A., Dahle C., Gerstorf D., Acker J.D. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex 2005, 15:1676-1689.
93. Reinvang I., Winjevoll I.L., Rootwelt H., Espeseth T. Working memory deficits in healthy APOE epsilon 4 carriers. Neuropsychologia 2010, 48:566-573.
94. Reischies F.M., Wertenauer F. Early diagnosis of dementia [in German]. Wien. Med. Wochenschr 2002, 152:66-71.
95. Resnick S.M., Pham D.L., Kraut M.A., Zonderman A.B., Davatzikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J. Neurosci 2003, 23:3295-3301.
96. Rombouts S.A., Barkhof F., Goekoop R., Stam C.J., Scheltens P. Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study. Hum. Brain Mapp 2005, 26:231-239.
97. Rombouts S.A., Damoiseaux J.S., Goekoop R., Barkhof F., Scheltens P., Smith S.M., Beckmann C.F. Model-free group analysis shows altered BOLD FMRI networks in dementia. Hum. Brain Mapp 2009, 30:256-266.
98. Rosen V.M., Bergeson J.L., Putnam K., Harwell A., Sunderland T. Working memory and apolipoprotein E: What's the connection?. Neuropsychologia 2002, 40:2226-2233.
99. Rozzini L., Chilovi B.V., Conti M., Bertoletti E., Delrio I., Trabucchi M., Padovani A. Conversion of amnestic mild cognitive impairment to dementia of Alzheimer type is independent to memory deterioration. Int. J. Geriatr. Psychiatry 2007, 22:1217-1222.
100. Sastre M., Klockgether T., Heneka M.T. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int. J. Dev. Neurosci 2006, 24:167-176.
101. Saunders N.L., Summers M.J. Attention and working memory deficits in mild cognitive impairment. J. Clin. Exp. Neuropsychol 2010, 32:350-357.
102. Saykin A.J., Wishart H.A., Rabin L.A., Flashman L.A., McHugh T.L., Mamourian A.C., Santulli R.B. Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Brain 2004, 127:1574-1583.
103. Scheff S.W., Price D.A., Schmitt F.A., Mufson E.J. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol. Aging 2006, 27:1372-1384.
104. Schönknecht P., Pantel J., Kruse A., Schröder J. Prevalence and natural course of aging-associated cognitive decline in a population-based sample of young-old subjects. Am. J. Psychiatry 2005, 162:2071-2077.
105. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
106. Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., Sabatini B.L. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci 2007, 27:2866-2875.
107. Small S.A., Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008, 60:534-542.
108. Sperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., Iwatsubo T., Jack C.R., Kaye J., Montine T.J., Park D.C., Reiman E.M., Rowe C.C., Siemers E., Stern Y., Yaffe K., Carrillo M.C., Thies B., Morrison-Bogorad M., Wagster M.V., Phelps C.H. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:280-292.
109. St. George-Hyslop P.H., Haines J.L., Farrer L.A., Polinsky R., Van Broeckhoven C., Goate A., McLachlan D.R., Orr H., Bruni A.C., Sorbi S., Rainero I., Foncin J.F., Pollen D., Cantu J.M., Tupler R., Voskresenskaya N., Mayeux R., Growden J., Fried V.A., Myers R.H., Nee L., Backhovens H., Martin J.J., Rossor M., Owen M.J., Mullan M., Percy M.E., Karlinsky H., Rich S., Heston L., Montesi M., Mortilla M., Nacmias N., Hardy J.F., Gusella J.A. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature 1990, 347:194-197. FAD Collaborative Study Group, et al.
110. Staff R.T., Murray A.D., Deary I.J., Whalley L.J. Generality and specificity in cognitive aging: a volumetric brain analysis. NeuroImage 2006, 30:1433-1440.
111. Tabert M.H., Manly J.J., Liu X., Pelton G.H., Rosenblum S., Jacobs M., Zamora D., Goodkind M., Bell K., Stern Y., Devanand D.P. Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch. Gen. Psychiatry 2006, 63:916-924.
112. Tanzi R.E., Bertram L. New frontiers in Alzheimer's disease genetics. Neuron 2001, 32:181-184.
113. Thulborn K.R., Martin C., Voyvodic J.T. Functional MR imaging using a visually guided saccade paradigm for comparing activation patterns in patients with probable Alzheimer's disease and in cognitively able elderly volunteers. AJNR Am. J. Neuroradiol 2000, 21:524-531.
114. Tisserand D.J., van Boxtel M.P., Pruessner J.C., Hofman P., Evans A.C., Jolles J. A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time. Cereb. Cortex 2004, 14:966-973.
115. Toepper M., Beblo T., Thomas C., Driessen M. Early detection of Alzheimer's disease: a new working memory paradigm. Int. J. Geriatr. Psychiatry 2008, 23:272-278.
116. Traykov L., Raoux N., Latour F., Gallo L., Hanon O., Baudic S., Bayle C., Wenisch E., Remy P., Rigaud A.S. Executive functions deficit in mild cognitive impairment. Cogn. Behav. Neurol 2007, 20:219-224.
117. Van Broeckhoven C., Genthe A.M., Vandenberghe A., Horsthemke B., Backhovens H., Raeymaekers P., Van Hul W., Wehnert A., Gheuens J., Cras P., et al. Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature 1987, 329:153-155.
118. Vogt B.A., Finch D.M., Olson C.R. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cerebral Cortex 1992, 2(6):435-443.
119. Whitwell J.L. Voxel-based morphometry: an automated technique for assessing structural changes in the brain. J. Neurosci 2009, 29:9661-9664.
120. Whitwell J.L., Petersen R.C., Negash S., Weigand S.D., Kantarci K., Ivnik R.J., Knopman D.S., Boeve B.F., Smith G.E., Jack C.R. Patterns of atrophy differ among specific subtypes of mild cognitive impairment. Arch. Neurol 2007, 64:1130-1138.
121. Wisdom N.M., Callahan J.L., Hawkins K.A. The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis. Neurobiol. Aging 2011, 32:63-74.
122. Wishart H.A., Saykin A.J., Rabin L.A., Santulli R.B., Flashman L.A., Guerin S.J., Mamourian A.C., Belloni D.R., Rhodes C.H., McAllister T.W. Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele. Am. J. Psychiatry 2006, 163:1603-1610.
123. Wolf S.A. Neuropsychologische Differenzialdiagnostik degenerativer Demenzen 2009, Thieme, Stuttgart, Germany.
124. Wolk D.A., Dickerson B.C. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:10256-10261. Alzheimer's Disease Neuroimaging Initiative.
125. Yetkin F.Z., Rosenberg R.N., Weiner M.F., Purdy P.D., Cullum C.M. FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer's disease. Eur. Radiol 2006, 16:193-206.