Synergistic effects of the combination of β-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells

Investigational New Drugs

Volumn 30, Issue 4, 2012, Pages 1449-1459

  Huang, Chin Shiu ^a   Lyu, Shih Chieh ^b   Hu, Miao Lin ^b  

^a ASIA UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Ionone; Focal adhesion kinase; Metastasis; Sorafenib; Tissue inhibitor matrix metalloproteinase

Indexed keywords

BETA IONONE; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; RAC1 PROTEIN; RHO KINASE; SORAFENIB; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; CELL ADHESION; CELL INVASION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SELECTIVITY; HEPATOMA CELL; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZENESULFONATES; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DRUG SYNERGISM; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; LIVER NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NORISOPRENOIDS; PHOSPHORYLATION; PYRIDINES; RAC1 GTP-BINDING PROTEIN; RHO GTP-BINDING PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84866735029     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9727-0     Document Type: Article

References (40)

1. Lopez PM, Villanueva A, Llovet JM. (2006) Systematic review: evidence-based management of hepatocellular carcinoma-an updated analysis of randomized controlled trials. Aliment Pharmacol Ther 23:1535-1547
2. Yu YM, Lin HC, Chang WC. (2008) Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9. Br J Nutr 100:731-738
3. Huang CS, Liao JW, Hu ML. (2008) Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice. J Nutr 138:538-543
4. Park SY, Lim SS, Kim JK, Kang IJ, Kim JS, Lee C, Kim J, Park JH. (2010) Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells. Br J Nutr 104:1272-1282
5. Yam JW, Tse EY, Ng IO. (2009) Role and significance of focal adhesion proteins in hepatocellular carcinoma. J Gastroenterol Hepatol 24:520-530
6. Zhao J, Guan JL. (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28:35-49
7. Chen JS, Huang XH, Wang Q, Chen XL, Fu XH, Tan HX, Zhang LJ, Li W, Bi J. (2010) FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin Exp Metastasis 27:71-82
8. Itoh T, Hayashi Y, Kanamaru T, Morita Y, Suzuki S, Wang W, Zhou L, Rui JA, Yamamoto M, Kuroda Y, Itoh H. (2000) Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma. J Gastroenterol Hepatol 15:422-430
9. Etienne-Manneville S, Hall A. (2002) Rho GTPases in cell biology. Nature 420:629-635
10. Huang CS, Shih MK, Chuang CH, Hu ML. (2005) Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J Nutr 135:2119-2123
11. Keating GM, Santoro A. (2009) Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 69:223-240
12. Palmer DH. (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:2498-2499
13. Chen KF, Yu HC, Liu TH, Lee SS, Chen PJ, Cheng AL. (2010) Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol 52:88-95
14. Ou DL, Shen YC, Liang JD, Liou JY, Yu SL, Fan HH, Wang DS, Lu YS, Hsu C, Cheng AL. (2009) Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinoma. Clin Cancer Res 15:5820-5828
15. Zhao JD, Liu J, Ren ZG, Gu K, Zhou ZH, Li WT, Chen Z, Xu ZY, Liu LM, Jiang GL. (2010) Maintenance of Sorafenib following combined therapy of three-dimensional conformal radiation therapy/intensity-modulated radiation therapy and transcatheter arterial chemoembolization in patients with locally advanced hepatocellular carcinoma: a phase I/II study. Radiat Oncol 5:12
16. Yang J, Liu RH. (2009) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J Agric Food Chem 57:8581-8586
17. Shiau RJ, Chen KY, Wen YD, Chuang CH, Yeh SL. (2010) Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. Eur J Nutr 49:19-25
18. Wu XZ, Shi PC, Hu P, Chen Y, Ding SS. (2006)N-all-trans-retinoyl-Lproline inhibits metastatic potential of hepatocellular carcinoma cells. Cell Biol Int 30:672-680
19. Roy Choudhury S, Karmakar S, Banik NL, Ray SK. (2010) Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplification. Invest New Drugs 28:812-824
20. Ganslmayer M, Ocker M, Zopf S, Leitner S, Hahn EG, Schuppan D, Herold C. (2004) A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells. Oncol Rep 11:943-950
21. KimMO, Moon DO, Kang CH, Kwon TK, Choi YH, KimGY(2010) beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity. Mol Cancer Ther 9:833-843
22. Liu JR, Sun XR, Dong HW, Sun CH, Sun WG, Chen BQ, Song YQ, Yang BF. (2008) beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int J Cancer 122:2689-2698
23. Cardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS. (2011) Chemopreventive effects of beta-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 22:130-135
24. Lin JR, Chen BQ, Yang YM, Sun XR, Dong H, Wang Q, Yang B. (2005) Inhibitory effect of potential metastasis in SGC-7901 cells induced by beta-ionone. Wei Sheng Yan Jiu 34:435-438
25. Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. (1997) Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol 74:111-122
26. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
27. Phillips HJ. (1973) Dye exclusion tests for cell viability. In: Tissue culture in method and applications. pp. 406-408. Academic. Press, London
28. Repesh LA. (1989) A new in vitro assay for quantitating tumor cell invasion. Invas Metast 9:192-208
29. Yang CM, Liu YZ, Liao JW, Hu ML. (2010) The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis 27:341-349
30. Huang CS, Fan YE, Lin CY, Hu ML. (2007) Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein, J Nutr Biochem 18:449-456
31. Chuang CH, Huang CS, Hu ML. (2010) Vitamin E and rutin synergistically inhibit expression of vascular endothelial growth factor through down-regulation of binding activity of activator protein-1 in human promyelocytic leukemia. (HL-60) cells. Chem Biol Interact 183:434-441
32. Stahl W, Junghans A, de Boer B, Driomina ES, Briviba K, Sies H. (1998) Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett 427:305-308
33. Pong RC, Roark R, Ou JY, Fan J, Stanfield J, Frenkel E, Sagalowsky A, Hsieh JT. (2006) Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application. Cancer Res 66:8822-8828
34. Libra M, Scalisi A, Vella N, Clementi S, Sorio R, Stivala F, Spandidos DA, Mazzarino C. (2009) Uterine cervical carcinoma: role of matrix metalloproteinases. (review). Int J Oncol 34:897-903
35. Ramer R, Eichele K, Hinz B. (2007) Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells. Oncogene 26:5822-5827
36. Gouyer V, Conti M, Devos P, Zerimech F, Copin MC, Créme E, Wurtz A, Porte H, Huet G. (2005) Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Cancer 103:1676-1684
37. Hsu YL, Wu LY, Hou MF, Tsai EM, Lee JN, Liang HL, Jong YJ, Hung CH, Kuo PL. (2011) Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB- 231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Mol Nutr Food Res 55:318-327
38. Meng XN, Jin Y, Yu Y, Bai J, Liu GY, Zhu J, Zhao YZ, Wang Z, Chen F, Lee KY, Fu SB. (2009) Characterisation of fibronectinmediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 101:327-334
39. Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390:632-636
40. Guo W, Giancotti FG. (2004) Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5:816-826