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Volumn 7, Issue 9, 2012, Pages 885-899

HSV, axonal transport and Alzheimers disease: In vitro and in vivo evidence for causal relationships

Author keywords

A; Alzheimers disease; amyloid precursor protein; APP; cerebrospinal fluid; CNS; encephalitis; fast axonal transport; HSV; senile plaques; trigeminal ganglion; trigeminal nucleus

Indexed keywords

VIRUS DNA;

EID: 84866708095     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.12.81     Document Type: Review
Times cited : (36)

References (111)
  • 1
    • 0001142641 scopus 로고    scopus 로고
    • Herpes simplex viruses and their replication
    • Fields Virology. Knipe D, Howley P (Eds) Williams & Wilkins, PA, USA
    • Roizman B, Knipe D. Herpes simplex viruses and their replication. In: Fields Virology. Knipe D, Howley P (Eds). Lippincott Williams & Wilkins, PA, USA 2399-2461 (2001).
    • (2001) Lippincott , pp. 2399-2461
    • Roizman, B.1    Knipe, D.2
  • 2
    • 0036932989 scopus 로고    scopus 로고
    • Stability and circularization of herpes simplex virus type 1 genomes in quiescently infected PC12 cultures
    • Su YH, Moxley MJ, Ng AK et al. Stability and circularization of herpes simplex virus type 1 genomes in quiescently infected PC12 cultures. J. Gen. Virol. 83(Pt 12), 2943-2950 (2002).
    • (2002) J. Gen. Virol , vol.83 , Issue.PART 12 , pp. 2943-2950
    • Su, Y.H.1    Moxley, M.J.2    Ng, A.K.3
  • 3
    • 0023267416 scopus 로고
    • Physical state of the latent herpes simplex virus genome in a mouse model system: Evidence suggesting an episomal state
    • Mellerick DM, Fraser NW. Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology 158(2), 265-275 (1987).
    • (1987) Virology , vol.158 , Issue.2 , pp. 265-275
    • Mellerick, D.M.1    Fraser, N.W.2
  • 4
    • 78650661438 scopus 로고    scopus 로고
    • Corneal latency and transmission of herpes simplex virus-1
    • Farooq AV, Shukla D. Corneal latency and transmission of herpes simplex virus-1. Future Virol. 6(1), 101-108 (2011).
    • (2011) Future Virol , vol.6 , Issue.1 , pp. 101-108
    • Farooq, A.V.1    Shukla, D.2
  • 5
    • 7444246101 scopus 로고    scopus 로고
    • Perspectives on herpes-APP interactions
    • Bearer EL. Perspectives on herpes-APP interactions. Aging Cell 3(2), 81-84 (2004).
    • (2004) Aging Cell , vol.3 , Issue.2 , pp. 81-84
    • Bearer, E.L.1
  • 6
    • 84866674561 scopus 로고    scopus 로고
    • Commentary on 'Fast anterograde transport of herpes simplex virus: Role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al
    • Aging Cell 3(2) 79-80 2004
    • Itzhaki RF, Dobson CB, Wozniak MA. Commentary on 'Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease' by Prasanna Satpute-Krishnan et al. Aging Cell 2(6), 305-318 (2003). Aging Cell 3(2), 79-80 (2004).
    • (2003) Aging Cell , vol.2 , Issue.6 , pp. 305-318
    • Itzhaki, R.F.1    Dobson, C.B.2    Wozniak, M.A.3
  • 7
    • 79953315804 scopus 로고    scopus 로고
    • Herpes simplex virus dances with amyloid precursor protein while exiting the cell
    • Cheng SB, Ferland P, Webster P, Bearer EL. Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS One 6(3), e17966 (2011).
    • (2011) PLoS One , vol.6 , Issue.3
    • Cheng, S.B.1    Ferland, P.2    Webster, P.3    Bearer, E.L.4
  • 8
    • 34548668986 scopus 로고    scopus 로고
    • Seroprevalence of herpes simplex virus type 1 in children in the United States
    • Xu F, Lee FK, Morrow RA et al. Seroprevalence of herpes simplex virus type 1 in children in the United States. J. Pediatr. 151(4), 374-377 (2007).
    • (2007) J. Pediatr , vol.151 , Issue.4 , pp. 374-377
    • Xu, F.1    Lee, F.K.2    Morrow, R.A.3
  • 9
    • 33747627183 scopus 로고    scopus 로고
    • Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States
    • Xu F, Sternberg MR, Kottiri BJ et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 296(8), 964-973 (2006).
    • (2006) JAMA , vol.296 , Issue.8 , pp. 964-973
    • Xu, F.1    Sternberg, M.R.2    Kottiri, B.J.3
  • 10
    • 0034973820 scopus 로고    scopus 로고
    • Review of 3200 serially received CSF samples submitted for type-specific HSV detection by PCR in the reference laboratory setting
    • Peter JB, Sevall JS. Review of 3200 serially received CSF samples submitted for type-specific HSV detection by PCR in the reference laboratory setting. Mol. Cell. Probes 15(3), 177-182 (2001).
    • (2001) Mol. Cell. Probes , vol.15 , Issue.3 , pp. 177-182
    • Peter, J.B.1    Sevall, J.S.2
  • 11
    • 0035168546 scopus 로고    scopus 로고
    • Latent HSV 1 virus in trigeminal ganglia: The optimal site for linking prevention of Alzheimer's disease to vaccination
    • discussion 717-719
    • Ball MJ, Mathews R, Steiner I et al. Latent HSV 1 virus in trigeminal ganglia: the optimal site for linking prevention of Alzheimer's disease to vaccination. Neurobiol. Aging 22(5), 705-709; discussion 717-719 (2001).
    • (2001) Neurobiol. Aging , vol.22 , Issue.5 , pp. 705-709
    • Ball, M.J.1    Mathews, R.2    Steiner, I.3
  • 12
    • 0032758643 scopus 로고    scopus 로고
    • Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia
    • Pevenstein SR, Williams RK, McChesney D, Mont EK, Smialek JE, Straus SE. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J. Virol. 73(12), 10514-10518 (1999).
    • (1999) J. Virol. , vol.73 , Issue.12 , pp. 10514-10518
    • Pevenstein, S.R.1    Williams, R.K.2    McChesney, D.3    Mont, E.K.4    Smialek, J.E.5    Straus, S.E.6
  • 13
    • 49149130501 scopus 로고    scopus 로고
    • The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender
    • Hill JM, Ball MJ, Neumann DM et al. The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender. J. Virol. 82(16), 8230-8234 (2008).
    • (2008) J. Virol , vol.82 , Issue.16 , pp. 8230-8234
    • Hill, J.M.1    Ball, M.J.2    Neumann, D.M.3
  • 14
    • 0026732704 scopus 로고
    • Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type
    • Jamieson GA, Maitland NJ, Wilcock GK, Yates CM, Itzhaki RF. Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type. J. Pathol. 167(4), 365-368 (1992).
    • (1992) J. Pathol , vol.167 , Issue.4 , pp. 365-368
    • Jamieson, G.A.1    Maitland, N.J.2    Wilcock, G.K.3    Yates, C.M.4    Itzhaki, R.F.5
  • 15
    • 0042344877 scopus 로고    scopus 로고
    • Herpesviruses in brains in Alzheimer's and Parkinson's diseases
    • Hemling N, Roytta M, Rinne J et al. Herpesviruses in brains in Alzheimer's and Parkinson's diseases. Ann. Neurol. 54(2), 267-271 (2003).
    • (2003) Ann. Neurol , vol.54 , Issue.2 , pp. 267-271
    • Hemling, N.1    Roytta, M.2    Rinne, J.3
  • 16
    • 3042743250 scopus 로고    scopus 로고
    • Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease
    • Mori I, Kimura Y, Naiki H et al. Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease. J. Med. Virol. 73(4), 605-611 (2004).
    • (2004) J. Med. Virol , vol.73 , Issue.4 , pp. 605-611
    • Mori, I.1    Kimura, Y.2    Naiki, H.3
  • 18
    • 0000295597 scopus 로고
    • Distribution of herpes simplex virus type 1 DNA in selected areas of normal and Alzheimer's disease brains: A PCR study
    • Bertrand P, Guillaume D, Hellauer K et al. Distribution of herpes simplex virus type 1 DNA in selected areas of normal and Alzheimer's disease brains: a PCR study. Neurodegeneration 2, 201-208 (1993).
    • (1993) Neurodegeneration , vol.2 , pp. 201-208
    • Bertrand, P.1    Guillaume, D.2    Hellauer, K.3
  • 19
    • 0036179097 scopus 로고    scopus 로고
    • Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients
    • Lin WR, Wozniak MA, Wilcock GK, Itzhaki RF. Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients. Neurobiol. Dis. 9(1), 82-87 (2002).
    • (2002) Neurobiol. Dis. , vol.9 , Issue.1 , pp. 82-87
    • Lin, W.R.1    Wozniak, M.A.2    Wilcock, G.K.3    Itzhaki, R.F.4
  • 20
    • 58449130099 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques
    • Wozniak MA, Mee AP, Itzhaki RF. Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. J. Pathol. 217(1), 131-138 (2009).
    • (2009) J. Pathol , vol.217 , Issue.1 , pp. 131-138
    • Wozniak, M.A.1    Mee, A.P.2    Itzhaki, R.F.3
  • 21
    • 0030805566 scopus 로고    scopus 로고
    • Presence of herpes simplex DNA in surgical tissue from human epileptic seizure foci detected by polymerase chain reaction: Preliminary study
    • Sanders VJ, Felisan SL, Waddell AE et al. Presence of herpes simplex DNA in surgical tissue from human epileptic seizure foci detected by polymerase chain reaction: preliminary study. Arch. Neurol. 54(8), 954-960 (1997).
    • (1997) Arch. Neurol , vol.54 , Issue.8 , pp. 954-960
    • Sanders, V.J.1    Felisan, S.L.2    Waddell, A.E.3
  • 22
    • 0029814261 scopus 로고    scopus 로고
    • Detection of herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction
    • Sanders VJ, Felisan S, Waddell A, Tourtellotte WW. Detection of herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction. J. Neurovirol. 2(4), 249-258 (1996).
    • (1996) J. Neurovirol , vol.2 , Issue.4 , pp. 249-258
    • Sanders, V.J.1    Felisan, S.2    Waddell, A.3    Tourtellotte, W.W.4
  • 24
    • 84864041221 scopus 로고    scopus 로고
    • Polymorphisms in TLR3 confers natural resistance to HSV-2 infection
    • Svensson A, Tunback P, Nordstrom I, Padyukov L, Eriksson K. Polymorphisms in TLR3 confers natural resistance to HSV-2 infection. J. Gen. Virol. 93(Pt 8), 1717-1724 (2012).
    • (2012) J. Gen. Virol , vol.93 , Issue.PART 8 , pp. 1717-1724
    • Svensson, A.1    Tunback, P.2    Nordstrom, I.3    Padyukov, L.4    Eriksson, K.5
  • 25
    • 84860337633 scopus 로고    scopus 로고
    • Host genetic factors in susceptibility to herpes simplex type 1 virus infection: Contribution of polymorphic genes at the interface of innate and adaptive immunity
    • Moraru M, Cisneros E, Gomez-Lozano N et al. Host genetic factors in susceptibility to herpes simplex type 1 virus infection: contribution of polymorphic genes at the interface of innate and adaptive immunity. J. Immunol. 188(9), 4412-4420 (2012).
    • (2012) J. Immunol , vol.188 , Issue.9 , pp. 4412-4420
    • Moraru, M.1    Cisneros, E.2    Gomez-Lozano, N.3
  • 26
    • 80054862386 scopus 로고    scopus 로고
    • Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk
    • Demontis D, Nyegaard M, Buttenschon HN et al. Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B(8), 913-922 (2011).
    • (2011) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.156 B , Issue.8 , pp. 913-922
    • Demontis, D.1    Nyegaard, M.2    Buttenschon, H.N.3
  • 27
    • 78049400346 scopus 로고    scopus 로고
    • A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women
    • Chatterjee K, Dandara C, Gyllensten U et al. A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women. J. Med. Virol. 82(12), 2082-2086 (2010).
    • (2010) J. Med. Virol , vol.82 , Issue.12 , pp. 2082-2086
    • Chatterjee, K.1    Dandara, C.2    Gyllensten, U.3
  • 28
    • 80155188581 scopus 로고    scopus 로고
    • C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: Description of a cold sore susceptibility gene
    • Kriesel JD, Jones BB, Matsunami N et al. C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene. J. Infect. Dis. 204(11), 1654-1662 (2011).
    • (2011) J. Infect. Dis. , vol.204 , Issue.11 , pp. 1654-1662
    • Kriesel, J.D.1    Jones, B.B.2    Matsunami, N.3
  • 30
    • 84862989850 scopus 로고    scopus 로고
    • Aging-related neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice
    • Guzman-Sanchez F, Valdivieso F, Burgos JS. Aging-related neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice. J. Alzheimers Dis. 30(4), 779-790 (2012).
    • (2012) J. Alzheimers Dis. , vol.30 , Issue.4 , pp. 779-790
    • Guzman-Sanchez, F.1    Valdivieso, F.2    Burgos, J.S.3
  • 31
    • 0035135076 scopus 로고    scopus 로고
    • Herpes simplex encephalitis: Involvement of apolipoprotein E. J. Neurol. Neurosurg
    • Lin W-R, Wozniak MA, Esiri MM, Klenerman P, Itzhaki RF. Herpes simplex encephalitis: involvement of apolipoprotein E. J. Neurol. Neurosurg. Psychiatry 70, 117-119 (2001).
    • (2001) Psychiatry , vol.70 , pp. 117-119
    • Lin, W.-R.1    Wozniak, M.A.2    Esiri, M.M.3    Klenerman, P.4    Itzhaki, R.F.5
  • 35
    • 31644446108 scopus 로고    scopus 로고
    • Herpes simplex virus type 1, apolipoprotein E, and cholesterol: A dangerous liaison in Alzheimer's disease and other disorders
    • Itzhaki RF, Wozniak MA. Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders. Prog. Lipid Res. 45(1), 73-90 (2006).
    • (2006) Prog. Lipid Res. , vol.45 , Issue.1 , pp. 73-90
    • Itzhaki, R.F.1    Wozniak, M.A.2
  • 36
    • 34249748515 scopus 로고    scopus 로고
    • Does apolipoprotein e determine outcome of infection by varicella zoster virus and by Epstein Barr virus?
    • Wozniak MA, Shipley SJ, Dobson CB et al. Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus? Eur. J. Hum. Genet. 15(6), 672-678 (2007).
    • (2007) Eur. J. Hum. Genet , vol.15 , Issue.6 , pp. 672-678
    • Wozniak, M.A.1    Shipley, S.J.2    Dobson, C.B.3
  • 37
    • 29144468943 scopus 로고    scopus 로고
    • Investigating the presence of human herpesvirus 7 and 8 in multiple sclerosis and normal control brain tissue
    • Opsahl ML, Kennedy PG. Investigating the presence of human herpesvirus 7 and 8 in multiple sclerosis and normal control brain tissue. J. Neurol. Sci. 240(1-2), 37-44 (2006).
    • (2006) J. Neurol. Sci. , vol.240 , Issue.1-2 , pp. 37-44
    • Opsahl, M.L.1    Kennedy, P.G.2
  • 38
    • 67649962189 scopus 로고    scopus 로고
    • Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease?
    • Honjo K, Van Reekum R, Verhoeff NP. Alzheimer's disease and infection: do infectious agents contribute to progression of Alzheimer's disease? Alzheimers Dement. 5(4), 348-360 (2009).
    • (2009) Alzheimers Dement , vol.5 , Issue.4 , pp. 348-360
    • Honjo, K.1    Van Reekum, R.2    Verhoeff, N.P.3
  • 39
    • 84855666303 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy: Clinical and molecular aspects
    • Tavazzi E, White MK, Khalili K. Progressive multifocal leukoencephalopathy: clinical and molecular aspects. Rev. Med. Virol. 22(1), 18-32 (2012).
    • (2012) Rev. Med. Virol. , vol.22 , Issue.1 , pp. 18-32
    • Tavazzi, E.1    White, M.K.2    Khalili, K.3
  • 40
    • 79961122181 scopus 로고    scopus 로고
    • Alzheimer's disease - A neurospirochetosis Analysis of the evidence following Koch's and Hill's criteria
    • Miklossy J. Alzheimer's disease-a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria. J. Neuroinflammation 8, 90 (2011).
    • (2011) J. Neuroinflammation , vol.8 , pp. 90
    • Miklossy, J.1
  • 41
    • 12844250088 scopus 로고    scopus 로고
    • Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease
    • discussion 673-681
    • Miklossy J, Khalili K, Gern L et al. Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. J. Alzheimers Dis. 6(6), 639-649; discussion 673-681 (2004).
    • (2004) J. Alzheimers Dis. , vol.6 , Issue.6 , pp. 639-649
    • Miklossy, J.1    Khalili, K.2    Gern, L.3
  • 42
    • 33846885661 scopus 로고    scopus 로고
    • Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus
    • Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y. Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. 9(2), 142-149 (2007).
    • (2007) Microbes Infect , vol.9 , Issue.2 , pp. 142-149
    • Ushijima, Y.1    Luo, C.2    Goshima, F.3    Yamauchi, Y.4    Kimura, H.5    Nishiyama, Y.6
  • 43
    • 77951457573 scopus 로고    scopus 로고
    • Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations
    • Szpara ML, Parsons L, Enquist LW. Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations. J. Virol. 84(10), 5303-5313 (2010).
    • (2010) J. Virol , vol.84 , Issue.10 , pp. 5303-5313
    • Szpara, M.L.1    Parsons, L.2    Enquist, L.W.3
  • 44
    • 0026333513 scopus 로고
    • Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2
    • McGeoch DJ, Cunningham C, Mcintyre G, Dolan A. Comparative sequence analysis of the long repeat regions and adjoining parts of the long unique regions in the genomes of herpes simplex viruses types 1 and 2. J. Gen. Virol. 72 (Pt 12), 3057-3075 (1991).
    • (1991) J. Gen. Virol , vol.72 , Issue.PART 12 , pp. 3057-3075
    • McGeoch, D.J.1    Cunningham, C.2    McIntyre, G.3    Dolan, A.4
  • 45
    • 0023056480 scopus 로고
    • Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1
    • Mcgeoch DJ, Dolan A, Donald S, Brauer DH. Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1. Nucleic Acids Res. 14(4), 1727-1745 (1986).
    • (1986) Nucleic Acids Res. , vol.14 , Issue.4 , pp. 1727-1745
    • McGeoch, D.J.1    Dolan, A.2    Donald, S.3    Brauer, D.H.4
  • 46
    • 0027337788 scopus 로고
    • Herpes simplex encephalitis. Early diagnosis and immune activation in the acute stage and during long-term follow-up
    • Aurelius E. Herpes simplex encephalitis. Early diagnosis and immune activation in the acute stage and during long-term follow-up. Scand. J. Infect. Dis. Suppl. 89, 3-62 (1993).
    • (1993) Scand. J. Infect. Dis. Suppl , vol.89 , pp. 3-62
    • Aurelius, E.1
  • 48
    • 43249130506 scopus 로고    scopus 로고
    • Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts
    • Cohrs RJ, Mehta SK, Schmid DS, Gilden DH, Pierson DL. Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. J. Med. Virol. 80(6), 1116-1122 (2008).
    • (2008) J. Med. Virol , vol.80 , Issue.6 , pp. 1116-1122
    • Cohrs, R.J.1    Mehta, S.K.2    Schmid, D.S.3    Gilden, D.H.4    Pierson, D.L.5
  • 49
    • 80052220153 scopus 로고    scopus 로고
    • Persistence of varicella zoster virus DNA in saliva after herpes zoster
    • Nagel MA, Choe A, Cohrs RJ et al. Persistence of varicella zoster virus DNA in saliva after herpes zoster. J. Infect. Dis. 204(6), 820-824 (2011).
    • (2011) J. Infect. Dis. , vol.204 , Issue.6 , pp. 820-824
    • Nagel, M.A.1    Choe, A.2    Cohrs, R.J.3
  • 51
    • 0018251481 scopus 로고
    • Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine
    • Fyfe JA, Keller PM, Furman PA, Miller RL, Elion GB. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine. J. Biol. Chem. 253(24), 8721-8727 (1978).
    • (1978) J. Biol. Chem. , vol.253 , Issue.24 , pp. 8721-8727
    • Fyfe, J.A.1    Keller, P.M.2    Furman, P.A.3    Miller, R.L.4    Elion, G.B.5
  • 52
    • 0017811137 scopus 로고
    • 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group
    • Schaeffer HJ, Beauchamp L, De Miranda P, Elion GB, Bauer DJ, Collins P. 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature 272(5654), 583-585 (1978).
    • (1978) Nature , vol.272 , Issue.5654 , pp. 583-585
    • Schaeffer, H.J.1    Beauchamp, L.2    De Miranda, P.3    Elion, G.B.4    Bauer, D.J.5    Collins, P.6
  • 53
    • 0027754719 scopus 로고
    • Acyclovir: Discovery, mechanism of action, and selectivity
    • Elion GB. Acyclovir: discovery, mechanism of action, and selectivity. J. Med. Virol. (Suppl. 1), 2-6 (1993).
    • (1993) J. Med. Virol. , Issue.SUPPL. 1 , pp. 2-6
    • Elion, G.B.1
  • 54
    • 0017743644 scopus 로고
    • Anti-herpes activity of deoxythymidine analogues: Specific dependence on virus-induced deoxythymidine kinase
    • De Clercq E, Krajewska E, Descamps J, Torrence PF. Anti-herpes activity of deoxythymidine analogues: specific dependence on virus-induced deoxythymidine kinase. Mol. Pharmacol. 13(5), 980-984 (1977).
    • (1977) Mol. Pharmacol. , vol.13 , Issue.5 , pp. 980-984
    • De Clercq, E.1    Krajewska, E.2    Descamps, J.3    Torrence, P.F.4
  • 55
    • 84857082958 scopus 로고    scopus 로고
    • The use of antiviral drugs during the neonatal period
    • Whitley RJ. The use of antiviral drugs during the neonatal period. Clin. Perinatol. 39(1), 69-81 (2012).
    • (2012) Clin. Perinatol , vol.39 , Issue.1 , pp. 69-81
    • Whitley, R.J.1
  • 57
    • 77954390093 scopus 로고    scopus 로고
    • Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child
    • Brown WD, Bearer EL, Donahue JE. Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child. J. Child Neurol. 25(7), 901-908 (2010).
    • (2010) J. Child Neurol , vol.25 , Issue.7 , pp. 901-908
    • Brown, W.D.1    Bearer, E.L.2    Donahue, J.E.3
  • 58
    • 80053514321 scopus 로고    scopus 로고
    • Oral acyclovir suppression and neurodevelopment after neonatal herpes
    • Kimberlin DW, Whitley RJ, Wan W et al. Oral acyclovir suppression and neurodevelopment after neonatal herpes. N. Engl. J. Med. 365(14), 1284-1292 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.14 , pp. 1284-1292
    • Kimberlin, D.W.1    Whitley, R.J.2    Wan, W.3
  • 59
    • 29644440011 scopus 로고    scopus 로고
    • Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease
    • Jankowsky JL, Slunt HH, Gonzales V et al. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2(12), e355 (2005).
    • (2005) PLoS Med. , vol.2 , Issue.12
    • Jankowsky, J.L.1    Slunt, H.H.2    Gonzales, V.3
  • 60
    • 0034608952 scopus 로고    scopus 로고
    • Retrograde axonal transport of herpes simplex virus: Evidence for a single mechanism and a role for tegument
    • Bearer EL, Breakefield XO, Schuback D, Reese TS, Lavail JH. Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Proc. Natl Acad. Sci. USA 97(14), 8146-8150 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.14 , pp. 8146-8150
    • Bearer, E.L.1    Breakefield, X.O.2    Schuback, D.3    Reese, T.S.4    Lavail, J.H.5
  • 61
    • 0035986706 scopus 로고    scopus 로고
    • The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: Tracks, motors, and polymerization machines
    • Bearer EL, Satpute-Krishnan P. The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines. Curr. Drug Targets Infect. Disord. 2(3), 247-264 (2002).
    • (2002) Curr. Drug Targets Infect. Disord , vol.2 , Issue.3 , pp. 247-264
    • Bearer, E.L.1    Satpute-Krishnan, P.2
  • 62
    • 2542424286 scopus 로고    scopus 로고
    • Fast anterograde transport of herpes simplex virus: Role for the amyloid precursor protein of alzheimer's disease
    • Satpute-Krishnan P, Degiorgis JA, Bearer EL. Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease. Aging Cell 2(6), 305-318 (2003).
    • (2003) Aging Cell , vol.2 , Issue.6 , pp. 305-318
    • Satpute-Krishnan, P.1    Degiorgis, J.A.2    Bearer, E.L.3
  • 63
    • 34547133482 scopus 로고    scopus 로고
    • A herpes simplex virus gD-YFP fusion glycoprotein is transported separately from viral capsids in neuronal axons
    • Snyder A, Bruun B, Browne HM, Johnson DC. A herpes simplex virus gD-YFP fusion glycoprotein is transported separately from viral capsids in neuronal axons. J. Virol. 81(15), 8337-8340 (2007).
    • (2007) J. Virol , vol.81 , Issue.15 , pp. 8337-8340
    • Snyder, A.1    Bruun, B.2    Browne, H.M.3    Johnson, D.C.4
  • 64
    • 55249103906 scopus 로고    scopus 로고
    • Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons
    • Snyder A, Polcicova K, Johnson DC. Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons. J. Virol. 82(21), 10613-10624 (2008).
    • (2008) J. Virol , vol.82 , Issue.21 , pp. 10613-10624
    • Snyder, A.1    Polcicova, K.2    Johnson, D.C.3
  • 65
    • 33750742492 scopus 로고    scopus 로고
    • Herpes simplex virus capsids are transported in neuronal axons without an envelope containing the viral glycoproteins
    • Snyder A, Wisner TW, Johnson DC. Herpes simplex virus capsids are transported in neuronal axons without an envelope containing the viral glycoproteins. J. Virol. 80(22), 11165-11177 (2006).
    • (2006) J. Virol , vol.80 , Issue.22 , pp. 11165-11177
    • Snyder, A.1    Wisner, T.W.2    Johnson, D.C.3
  • 66
    • 78649434392 scopus 로고    scopus 로고
    • Resolving the assembly state of herpes simplex virus during axon transport by live-cell imaging
    • Antinone SE, Zaichick SV, Smith GA. Resolving the assembly state of herpes simplex virus during axon transport by live-cell imaging. J. Virol. 84(24), 13019-13030 (2010).
    • (2010) J. Virol , vol.84 , Issue.24 , pp. 13019-13030
    • Antinone, S.E.1    Zaichick, S.V.2    Smith, G.A.3
  • 67
    • 78649438708 scopus 로고    scopus 로고
    • Ultrastructural analysis of virion formation and intraaxonal transport of herpes simplex virus type 1 in primary rat neurons
    • Negatsch A, Granzow H, Maresch C et al. Ultrastructural analysis of virion formation and intraaxonal transport of herpes simplex virus type 1 in primary rat neurons. J. Virol. 84(24), 13031-13035 (2010).
    • (2010) J. Virol , vol.84 , Issue.24 , pp. 13031-13035
    • Negatsch, A.1    Granzow, H.2    Maresch, C.3
  • 68
    • 0032889509 scopus 로고    scopus 로고
    • Intracellular traff?ic of herpes simplex virus glycoprotein gE: Characterization of the sorting signals required for its trans-Golgi network localization
    • Alconada A, Bauer U, Sodeik B, Hoflack B. Intracellular traff?ic of herpes simplex virus glycoprotein gE: characterization of the sorting signals required for its trans-Golgi network localization. J. Virol. 73, 377-387 (1999).
    • (1999) J. Virol. , vol.73 , pp. 377-387
    • Alconada, A.1    Bauer, U.2    Sodeik, B.3    Hoflack, B.4
  • 69
    • 84855255301 scopus 로고    scopus 로고
    • Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons
    • Ibiricu I, Huiskonen JT, Dohner K, Bradke F, Sodeik B, Grunewald K. Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons. PLoS Pathog. 7(12), e1002406 (2011).
    • (2011) PLoS Pathog , vol.7 , Issue.12
    • Ibiricu, I.1    Huiskonen, J.T.2    Dohner, K.3    Bradke, F.4    Sodeik, B.5    Grunewald, K.6
  • 70
    • 77957652501 scopus 로고    scopus 로고
    • Plus-and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures
    • Radtke K, Kieneke D, Wolfstein A et al. Plus-and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. PLoS Pathog. 6(7), e1000991 (2010).
    • (2010) PLoS Pathog , vol.6 , Issue.7
    • Radtke, K.1    Kieneke, D.2    Wolfstein, A.3
  • 71
    • 21644443202 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress
    • Turcotte S, Letellier J, Lippe R. Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress. J. Virol. 79(14), 8847-8860 (2005).
    • (2005) J. Virol , vol.79 , Issue.14 , pp. 8847-8860
    • Turcotte, S.1    Letellier, J.2    Lippe, R.3
  • 72
    • 33748856035 scopus 로고    scopus 로고
    • The cycle of human herpes simplex virus infection: Virus transport and immune control
    • Cunningham AL, Diefenbach RJ, Miranda-Saksena M et al. The cycle of human herpes simplex virus infection: virus transport and immune control. J. Infect. Dis. 194 Suppl 1, S11-18 (2006).
    • (2006) J. Infect. Dis. , vol.194 , Issue.SUPPL. 1
    • Cunningham, A.L.1    Diefenbach, R.J.2    Miranda-Saksena, M.3
  • 74
    • 0005599756 scopus 로고    scopus 로고
    • Anterograde transport of herpes simplex virus proteins in axons of peripheral human fetal neurons: An immunoelectron microscopy study
    • Holland DJ, Miranda-Saksena M, Boadle RA, Armati P, Cunningham AL. Anterograde transport of herpes simplex virus proteins in axons of peripheral human fetal neurons: an immunoelectron microscopy study. J. Virol. 73(10), 8503-8511 (1999).
    • (1999) J. Virol , vol.73 , Issue.10 , pp. 8503-8511
    • Holland, D.J.1    Miranda-Saksena, M.2    Boadle, R.A.3    Armati, P.4    Cunningham, A.L.5
  • 75
    • 0033937283 scopus 로고    scopus 로고
    • Anterograde transport of herpes simplex virus type 1 in cultured, dissociated human and rat dorsal root ganglion neurons
    • Miranda-Saksena M, Armati P, Boadle RA, Holland DJ, Cunningham AL. Anterograde transport of herpes simplex virus type 1 in cultured, dissociated human and rat dorsal root ganglion neurons. J. Virol. 74(4), 1827-1839 (2000).
    • (2000) J. Virol , vol.74 , Issue.4 , pp. 1827-1839
    • Miranda-Saksena, M.1    Armati, P.2    Boadle, R.A.3    Holland, D.J.4    Cunningham, A.L.5
  • 76
    • 0028285180 scopus 로고
    • Axonal transport of herpes simplex virions to epidermal cells: Evidence for a specialized mode of virus transport and assembly
    • Penfold ME, Armati P, Cunningham AL. Axonal transport of herpes simplex virions to epidermal cells: evidence for a specialized mode of virus transport and assembly. Proc. Natl Acad. Sci. USA 91(14), 6529-6533 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , Issue.14 , pp. 6529-6533
    • Penfold, M.E.1    Armati, P.2    Cunningham, A.L.3
  • 77
    • 0022531958 scopus 로고
    • Neuritic transport of herpes simplex virus in rat sensory neurons in vitro. Effects of substances interacting with microtubular function and axonal flow [nocodazole, taxol and erythro-9-3-(2-hydroxynonyl)adenine]
    • Kristensson K, Lycke E, Roytta M, Svennerholm B, Vahlne A. Neuritic transport of herpes simplex virus in rat sensory neurons in vitro. Effects of substances interacting with microtubular function and axonal flow [nocodazole, taxol and erythro-9-3-(2-hydroxynonyl)adenine]. J. Gen. Virol. 67 (Pt 9), 2023-2028 (1986).
    • (1986) J. Gen. Virol , vol.67 , Issue.PART 9 , pp. 2023-2028
    • Kristensson, K.1    Lycke, E.2    Roytta, M.3    Svennerholm, B.4    Vahlne, A.5
  • 78
    • 0023772685 scopus 로고
    • Herpes simplex virus infection of the human sensory neuron. An electron microscopy study
    • Lycke E, Hamark B, Johansson M, Krotochwil A, Lycke J, Svennerholm B. Herpes simplex virus infection of the human sensory neuron. An electron microscopy study. Arch. Virol. 101(1-2), 87-104 (1988).
    • (1988) Arch. Virol , vol.101 , Issue.1-2 , pp. 87-104
    • Lycke, E.1    Hamark, B.2    Johansson, M.3    Krotochwil, A.4    Lycke, J.5    Svennerholm, B.6
  • 79
    • 0021320804 scopus 로고
    • Uptake and transport of herpes simplex virus in neurites of rat dorsal root ganglia cells in culture
    • Lycke E, Kristensson K, Svennerholm B, Vahlne A, Ziegler R. Uptake and transport of herpes simplex virus in neurites of rat dorsal root ganglia cells in culture. J. Gen. Virol. 65 (Pt 1), 55-64 (1984).
    • (1984) J. Gen. Virol , vol.65 , Issue.PART 1 , pp. 55-64
    • Lycke, E.1    Kristensson, K.2    Svennerholm, B.3    Vahlne, A.4    Ziegler, R.5
  • 80
    • 34247847742 scopus 로고    scopus 로고
    • Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid
    • Lavail JH, Tauscher AN, Sucher A, Harrabi O, Brandimarti R. Viral regulation of the long distance axonal transport of herpes simplex virus nucleocapsid. Neuroscience 146(3), 974-985 (2007).
    • (2007) Neuroscience , vol.146 , Issue.3 , pp. 974-985
    • Lavail, J.H.1    Tauscher, A.N.2    Sucher, A.3    Harrabi, O.4    Brandimarti, R.5
  • 81
    • 33646168140 scopus 로고    scopus 로고
    • Reconstitution of herpes simplex virus microtubule-dependent trafficking in vitro
    • Lee GE, Murray JW, Wolkoff AW, Wilson DW. Reconstitution of herpes simplex virus microtubule-dependent trafficking in vitro. J. Virol. 80(9), 4264-4275 (2006).
    • (2006) J. Virol. , vol.80 , Issue.9 , pp. 4264-4275
    • Lee, G.E.1    Murray, J.W.2    Wolkoff, A.W.3    Wilson, D.W.4
  • 82
    • 33750823234 scopus 로고    scopus 로고
    • A peptide zipcode sufficient for anterograde transport within amyloid precursor protein. Proc
    • Satpute-Krishnan P, Degiorgis JA, Conley MP, Jang M, Bearer EL. A peptide zipcode sufficient for anterograde transport within amyloid precursor protein. Proc. Natl Acad. Sci. USA 103(44), 16532-16537 (2006).
    • (2006) Natl Acad. Sci. USA , vol.103 , Issue.44 , pp. 16532-16537
    • Satpute-Krishnan, P.1    Degiorgis, J.A.2    Conley, M.P.3    Jang, M.4    Bearer, E.L.5
  • 83
    • 69249219334 scopus 로고    scopus 로고
    • Anterograde spread of herpes simplex virus type 1 requires glycoprotein e and glycoprotein i but not Us9
    • Mcgraw HM, Awasthi S, Wojcechowskyj JA, Friedman HM. Anterograde spread of herpes simplex virus type 1 requires glycoprotein E and glycoprotein I but not Us9. J. Virol. 83(17), 8315-8326 (2009).
    • (2009) J. Virol. , vol.83 , Issue.17 , pp. 8315-8326
    • McGraw, H.M.1    Awasthi, S.2    Wojcechowskyj, J.A.3    Friedman, H.M.4
  • 84
    • 33845985558 scopus 로고    scopus 로고
    • A conserved region of the herpes simplex virus type 1 tegument protein VP22 facilitates interaction with the cytoplasmic tail of glycoprotein e (gE)
    • O'Regan KJ, Bucks MA, Murphy MA, Wills JW, Courtney RJ. A conserved region of the herpes simplex virus type 1 tegument protein VP22 facilitates interaction with the cytoplasmic tail of glycoprotein E (gE). Virology 358(1), 192-200 (2007).
    • (2007) Virology , vol.358 , Issue.1 , pp. 192-200
    • O'Regan, K.J.1    Bucks, M.A.2    Murphy, M.A.3    Wills, J.W.4    Courtney, R.J.5
  • 85
    • 0033912099 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 glycoprotein e domains involved in virus spread and disease
    • Saldanha CE, Lubinski J, Martin C et al. Herpes simplex virus type 1 glycoprotein E domains involved in virus spread and disease. J. Virol. 74(15), 6712-6719 (2000).
    • (2000) J. Virol , vol.74 , Issue.15 , pp. 6712-6719
    • Saldanha, C.E.1    Lubinski, J.2    Martin, C.3
  • 86
    • 27144440815 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins
    • Wang F, Tang W, McGraw HM, Bennett J, Enquist LW, Friedman HM. Herpes simplex virus type 1 glycoprotein E is required for axonal localization of capsid, tegument, and membrane glycoproteins. J. Virol. 79(21), 13362-13372 (2005).
    • (2005) J. Virol , vol.79 , Issue.21 , pp. 13362-13372
    • Wang, F.1    Tang, W.2    McGraw, H.M.3    Bennett, J.4    Enquist, L.W.5    Friedman, H.M.6
  • 87
    • 77955654733 scopus 로고    scopus 로고
    • Herpes simplex virus type 2 glycoprotein e is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons
    • Wang F, Zumbrun EE, Huang J, Si H, Makaroun L, Friedman HM. Herpes simplex virus type 2 glycoprotein E is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons. Virology 405(2), 269-279 (2010).
    • (2010) Virology , vol.405 , Issue.2 , pp. 269-279
    • Wang, F.1    Zumbrun, E.E.2    Huang, J.3    Si, H.4    Makaroun, L.5    Friedman, H.M.6
  • 88
    • 0028849767 scopus 로고
    • Glycoproteins e and i facilitate neuron-to-neuron spread of herpes simplex virus
    • Dingwell KS, Doering LC, Johnson DC. Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus. J. Virol. 69(11), 7087-7098 (1995).
    • (1995) J. Virol , vol.69 , Issue.11 , pp. 7087-7098
    • Dingwell, K.S.1    Doering, L.C.2    Johnson, D.C.3
  • 89
    • 33645221124 scopus 로고    scopus 로고
    • Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread
    • Farnsworth A, Johnson DC. Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread. J. Virol. 80(7), 3167-3179 (2006).
    • (2006) J. Virol , vol.80 , Issue.7 , pp. 3167-3179
    • Farnsworth, A.1    Johnson, D.C.2
  • 90
    • 33845775712 scopus 로고    scopus 로고
    • Cytoplasmic residues of herpes simplex virus glycoprotein gE required for secondary envelopment and binding of tegument proteins VP22 and UL11 to gE and gD
    • Farnsworth A, Wisner TW, Johnson DC. Cytoplasmic residues of herpes simplex virus glycoprotein gE required for secondary envelopment and binding of tegument proteins VP22 and UL11 to gE and gD. J. Virol. 81(1), 319-331 (2007).
    • (2007) J. Virol , vol.81 , Issue.1 , pp. 319-331
    • Farnsworth, A.1    Wisner, T.W.2    Johnson, D.C.3
  • 91
    • 0036097682 scopus 로고    scopus 로고
    • Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread
    • Huber MT, Tomazin R, Wisner T, Boname J, Johnson DC. Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread. J. Virol. 76(11), 5748-5758 (2002).
    • (2002) J. Virol , vol.76 , Issue.11 , pp. 5748-5758
    • Huber, M.T.1    Tomazin, R.2    Wisner, T.3    Boname, J.4    Johnson, D.C.5
  • 92
    • 35148896264 scopus 로고    scopus 로고
    • Pseudorabies virus Us9 directs axonal sorting of viral capsids
    • Lyman MG, Feierbach B, Curanovic D, Bisher M, Enquist LW. Pseudorabies virus Us9 directs axonal sorting of viral capsids. J. Virol. 81(20), 11363-11371 (2007).
    • (2007) J. Virol , vol.81 , Issue.20 , pp. 11363-11371
    • Lyman, M.G.1    Feierbach, B.2    Curanovic, D.3    Bisher, M.4    Enquist, L.W.5
  • 93
    • 84860505055 scopus 로고    scopus 로고
    • Visualization of an alphaherpesvirus membrane protein that is essential for anterograde axonal spread of infection in neurons
    • pii: e00063-12
    • Taylor MP, Kramer T, Lyman MG, Kratchmarov R, Enquist LW. Visualization of an alphaherpesvirus membrane protein that is essential for anterograde axonal spread of infection in neurons. MBio 3(2), pii: e00063-12 (2012).
    • (2012) MBio , vol.3 , Issue.2
    • Taylor, M.P.1    Kramer, T.2    Lyman, M.G.3    Kratchmarov, R.4    Enquist, L.W.5
  • 94
    • 78649757007 scopus 로고    scopus 로고
    • APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells
    • De Chiara G, Marcocci ME, Civitelli L et al. APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells. PLoS One 5(11), e13989 (2010).
    • (2010) PLoS One , vol.5 , Issue.11
    • De Chiara, G.1    Marcocci, M.E.2    Civitelli, L.3
  • 95
    • 80053646131 scopus 로고    scopus 로고
    • HSV-1 promotes Ca2+-mediated APP phosphorylation and Abeta accumulation in rat cortical neurons
    • Piacentini R, Civitelli L, Ripoli C et al. HSV-1 promotes Ca2+-mediated APP phosphorylation and Abeta accumulation in rat cortical neurons. Neurobiol. Aging 32(12), 2323.e13-e26 (2011).
    • (2011) Neurobiol. Aging , vol.32 , Issue.12
    • Piacentini, R.1    Civitelli, L.2    Ripoli, C.3
  • 96
    • 82755189739 scopus 로고    scopus 로고
    • Herpes simplex virus type i induces the accumulation of intracellular beta-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells
    • e19-e33
    • Santana S, Recuero M, Bullido MJ, Valdivieso F, Aldudo J. Herpes simplex virus type I induces the accumulation of intracellular beta-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells. Neurobiol. Aging 33(2), 430 e19-e33 (2012).
    • (2012) Neurobiol. Aging , vol.33 , Issue.2 , pp. 430
    • Santana, S.1    Recuero, M.2    Bullido, M.J.3    Valdivieso, F.4    Aldudo, J.5
  • 97
    • 36348931527 scopus 로고    scopus 로고
    • Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation
    • Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB. Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci. Lett. 429(2-3), 95-100 (2007).
    • (2007) Neurosci. Lett. , vol.429 , Issue.2-3 , pp. 95-100
    • Wozniak, M.A.1    Itzhaki, R.F.2    Shipley, S.J.3    Dobson, C.B.4
  • 98
    • 75249090200 scopus 로고    scopus 로고
    • Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?
    • Muresan V, Muresan Z. Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? Future Neurol. 4(6), 761-773 (2009).
    • (2009) Future Neurol , vol.4 , Issue.6 , pp. 761-773
    • Muresan, V.1    Muresan, Z.2
  • 99
    • 63849105306 scopus 로고    scopus 로고
    • The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites
    • Muresan V, Varvel NH, Lamb BT, Muresan Z. The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J. Neurosci. 29(11), 3565-3578 (2009).
    • (2009) J. Neurosci , vol.29 , Issue.11 , pp. 3565-3578
    • Muresan, V.1    Varvel, N.H.2    Lamb, B.T.3    Muresan, Z.4
  • 101
    • 84868095485 scopus 로고    scopus 로고
    • Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons
    • doi:10.1016/j. neurobiolaging.2012.02.031 Epub ahead of print
    • Braak H, Thal DR, Matschke J, Ghebremedhin E, Del Tredici K. Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons. Neurobiol. Aging doi:10.1016/j. neurobiolaging.2012.02.031 (2012) (Epub ahead of print).
    • (2012) Neurobiol. Aging
    • Braak, H.1    Thal, D.R.2    Matschke, J.3    Ghebremedhin, E.4    Del Tredici, K.5
  • 102
    • 40949152073 scopus 로고    scopus 로고
    • Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades
    • Carter CJ. Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological- signalling cascades. Neurochem. Int. 52(6), 920-934 (2008).
    • (2008) Neurochem. Int. , vol.52 , Issue.6 , pp. 920-934
    • Carter, C.J.1
  • 103
    • 80053918451 scopus 로고    scopus 로고
    • Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1
    • Wozniak MA, Frost AL, Preston CM, Itzhaki RF. Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One 6(10), e25152 (2011).
    • (2011) PLoS One , vol.6 , Issue.10
    • Wozniak, M.A.1    Frost, A.L.2    Preston, C.M.3    Itzhaki, R.F.4
  • 104
    • 84555191341 scopus 로고    scopus 로고
    • Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels
    • Feart C, Helmer C, Fleury H et al. Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels. PLoS One 6(12), e29480 (2011).
    • (2011) PLoS One , vol.6 , Issue.12
    • Feart, C.1    Helmer, C.2    Fleury, H.3
  • 105
    • 77949830350 scopus 로고    scopus 로고
    • The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide
    • Soscia SJ, Kirby JE, Washicosky KJ et al. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One 5(3), e9505 (2010).
    • (2010) PLoS One , vol.5 , Issue.3
    • Soscia, S.J.1    Kirby, J.E.2    Washicosky, K.J.3
  • 106
    • 84856390353 scopus 로고    scopus 로고
    • Emerging roles of pathogens in Alzheimer disease
    • Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev. Mol. Med. 13, e30 (2011).
    • (2011) Expert Rev. Mol. Med. , vol.13
    • Miklossy, J.1
  • 107
    • 79955865565 scopus 로고    scopus 로고
    • Monoclonal antibodies against beta-amyloid (Abeta) for the treatment of Alzheimer's disease: The Abeta target at a crossroads
    • Panza F, Frisardi V, Imbimbo BP, Seripa D, Solfrizzi V, Pilotto A. Monoclonal antibodies against beta-amyloid (Abeta) for the treatment of Alzheimer's disease: the Abeta target at a crossroads. Expert Opin. Biol. Ther. 11(6), 679-686 (2011).
    • (2011) Expert Opin. Biol. Ther. , vol.11 , Issue.6 , pp. 679-686
    • Panza, F.1    Frisardi, V.2    Imbimbo, B.P.3    Seripa, D.4    Solfrizzi, V.5    Pilotto, A.6
  • 108
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488(7409), 96-99(2012).
    • (2012) Nature , vol.488 , Issue.7409 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 109
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill AB. The environment and disease: association or causation? Proc. R. Soc. Med. 58, 295-300 (1965).
    • (1965) Proc. R. Soc. Med. , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 110
    • 0030060689 scopus 로고    scopus 로고
    • Sequence-based identification of microbial pathogens: A reconsideration of Koch's postulates
    • Fredericks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin. Microbiol. Rev. 9(1), 18-33 (1996).
    • (1996) Clin. Microbiol. Rev. , vol.9 , Issue.1 , pp. 18-33
    • Fredericks, D.N.1    Relman, D.A.2
  • 111
    • 56149113571 scopus 로고    scopus 로고
    • Seropositivity to herpes simplex virus antibodies and risk of alzheimer's disease: A population-based cohort study
    • Letenneur L, Peres K, Fleury H et al. Seropositivity to herpes simplex virus antibodies and risk of Alzheimer's disease: a population-based cohort study. PLoS One 3(11), e3637 (2008).
    • (2008) PLoS One , vol.3 , Issue.11
    • Letenneur, L.1    Peres, K.2    Fleury, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.