Herpesviruses in brain and Alzheimer's disease

Journal of Pathology

Volumn 197, Issue 3, 2002, Pages 395-402

  Morrison, M L ^a   McCluggage, W G ^a   Price, G J ^b   Diamond, J ^b   Sheeran, M R M ^b   Mulholland, K M ^b   Walsh, M Y ^c   Montironi, R ^c   Bartels, P H ^d   Thompson, D ^d   Hamilton, P W ^d  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Alzheimer's disease; Brain; Cytomegalovirus; Herpes simplex virus type 2; Human herpesvirus 6; Polymerase chain reaction

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN INJURY; BRAIN TISSUE; CELL CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; FRONTAL LOBE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TEMPORAL LOBE; VIRUS CARRIER; VIRUS STRAIN;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; BRAIN; CASE-CONTROL STUDIES; CYTOMEGALOVIRUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HERPESVIRUS 6, HUMAN; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION;

EID: 0036069904     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1127     Document Type: Article

References (39)

1. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
2. Alzheimer's disease, herpes virus in brain, apolipoprotein E4 and herpes labialis
3. Neurotropic viruses and Alzheimer's disease: A search for varicella zoster virus DNA by the polymerase chain reaction
4. HSV-1 and HSV-2 in herpes simplex encephalitis: A study of sixty-four cases in the United Kingdom
5. Necrotizing herpes simplex encephalitis as the cause of a progressive dementia syndrome
6. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis
7. Detection of herpes simplex virus (types 1 and 2) and human herpes virus 6 DNA in human brain tissue by polymerase chain reaction
8. Detection of herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction
9. The clinical implications of human herpesvirus 6 infection
10. Central nervous system complications in human herpesvirus-6 infection
11. Roseola infantum and other syndromes associated with acute HHV6 infection
12. Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions
13. Neuroinvasion and persistence of human herpesvirus 6 in children
14. Clinical and virological analysis of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications
15. Meningitis caused by human herpesvirus-6
16. Human herpesvirus 6 is associated with focal encephalitis
17. Encephalitis in immunocompetent patients due to herpes simplex virus type 1 or 2 as determined by type-specific polymerase chain reaction and antibody assays of cerebrospinal fluid
18. Cytomegalo-virus encephalitis
19. Cytomegalovirus infections of the nervous system
20. Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains
21. Sensitive non-isotopic DNA hybridisation assay or immediate-early antigen detection for rapid identification of human cytomegalovirus in urine
22. Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives
23. A multiplex PCR assay for the simultaneous detection of human herpesvirus 6 and human herpesvirus 7, with typing of HHV-6 by enzyme cleavage of PCR products
24. Use of recombinant plasmids to investigate the structure of the human cytomegalo-virus genome
25. The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases
26. Herpes simplex virus type 1 sequences are present in aged normal and Alzheimer's disease brain but absent in lymphocytes
27. Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type
28. Association of human herpesvirus 6 with the demyelinative lesions of progressive multifocal leukoencephalopathy
29. The HHV6 paradox: Ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach
30. Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS
31. Human herpesvirus-6 infection may predispose cells to superinfection by other viruses
32. Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer
33. Possible role of HHV-6 in the enhanced severity of HSV-1 keratitis
34. Differences in attachment between herpes simplex type 1 and type 2 viruses to neurons and glial cells
35. Differences in the role of glycoprotein C of HSV-1 and HSV-2 in viral binding may contribute to serotype differences in cell tropism
36. Identification of structural features of heparan sulfate required for herpes simplex virus adsorption to cells
37. Cytomegalovirus infection of the CNS in non-compromised patients
38. Herpesvirus DNA detection in cerebral spinal fluid: Differences in clinical presentation between alpha-, beta-, and gamma-herpesviruses