Electrical stimulation ameliorates light-induced photoreceptor degeneration in vitro via suppressing the proinflammatory effect of microglia and enhancing the neurotrophic potential of Müller cells

Experimental Neurology

Volumn 238, Issue 2, 2012, Pages 192-208

  Zhou, Wen ting ^a   Ni, Ying qin ^a   Jin, Zi bing ^b   Zhang, Meng ^a   Wu, Ji hong ^a   Zhu, Ying ^a   Xu, Ge zhi ^a   Gan, De kang ^a  

^a EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Electrical stimulation; Light induced photoreceptor degeneration; Microglia activation; M ller cell reactive gliosis; Neurotrophic factor; Proinflammatory cytokine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ASSAY; CELL COUNT; CELL DEATH; CELL PROTECTION; CELL SHAPE; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ELECTROSTIMULATION; GLIOSIS; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MICROGLIA; MUELLER CELL; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTROPISM; NEWBORN; NICK END LABELING; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, CD; APOPTOSIS; CALCIUM-BINDING PROTEINS; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; ECTODYSPLASINS; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; LIGHT; MICROFILAMENT PROTEINS; MICROGLIA; NERVE GROWTH FACTORS; PHOTORECEPTOR CELLS, VERTEBRATE; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DEGENERATION; RNA, MESSENGER; TIME FACTORS;

EID: 84866704929     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.08.029     Document Type: Article

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