Differential distribution of serotonin receptor subtypes in BNSTALG neurons: Modulation by unpredictable shock stress

Neuroscience

Volumn 225, Issue , 2012, Pages 9-21

  Hazra, R ^a,b   Guo, J D ^a,b   Dabrowska, J ^a,b   Rainnie, D G ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT1A; Bed nucleus of the stria terminalis; Chronic stress; Deaf 1; Serotonin receptors; Single cell RT PCR

Indexed keywords

MESSENGER RNA; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BED NUCLEUS OF THE STRIA TERMINALIS; BRAIN FUNCTION; BRAIN LEVEL; BRAIN NERVE CELL; BRAIN NERVE CELL TYPE 1; BRAIN NERVE CELL TYPE 2; BRAIN NERVE CELL TYPE 3; BRAIN NUCLEUS; CELL ACTIVATION; CELL DISRUPTION; CELL FUNCTION; CELL TYPE; CONTROLLED STUDY; DEAF 1 GENE; MALE; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPRESSOR GENE; SEROTONINERGIC SYSTEM; STRESS; STRIA TERMINALIS; UNPREDICTABLE SHOCK STRESS; UPREGULATION;

ACOUSTIC STIMULATION; ANIMALS; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION; MALE; NEURONS; NUCLEAR PROTEINS; PATCH-CLAMP TECHNIQUES; PSYCHOACOUSTICS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, SEROTONIN; RNA, MESSENGER; SENSORY GATING; SEPTAL NUCLEI; STRESS, PSYCHOLOGICAL;

EID: 84866675236     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.08.014     Document Type: Article

References (100)

1. Ahima R.S., Harlan R.E. Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system. Neuroscience 1990, 39:579-604.
2. Albert P.R., Le Francois B., Millar A.M. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Mol Brain 2011, 4:21.
3. Albert P.R., Lemonde S. 5-HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist 2004, 10:575-593.
4. Alves F.H., Crestani C.C., Gomes F.V., Guimaraes F.S., Correa F.M., Resstel L.B. Cannabidiol injected into the bed nucleus of the stria terminalis modulates baroreflex activity through 5-HT1A receptors. Pharmacol Res 2010, 62:228-236.
5. Bonaventure P., Schotte A., Cras P., Leysen J.E. Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand. Receptors Channels 1997, 5:225-230.
6. Bota M., Sporns O., Swanson L.W. Neuroinformatics analysis of molecular expression patterns and neuron populations in gray matter regions: the rat BST as a rich exemplar. Brain Res 2012, 1450:174-193.
7. Bouwknecht J.A., Hijzen T.H., van der Gugten J., Dirks A., Maes R.A., Hen R., Geyer M.A., Olivier B. Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice. Neuroreport 2000, 11:4097-4102.
8. Casada J.H., Dafny N. Restraint and stimulation of bed nucleus of the stria terminalis produce similar stress-like behaviors. Brain Res Bull 1991, 27:207-212.
9. Chaouloff F. Serotonin, stress and corticoids. J Psychopharmacol 2000, 14:139-151.
10. Chaouloff F., Berton O., Mormede P. Serotonin and stress. Neuropsychopharmacology 1999, 21:28S-32S.
11. Choi D.C., Furay A.R., Evanson N.K., Ostrander M.M., Ulrich-Lai Y.M., Herman J.P. Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputs. J Neurosci 2007, 27:2025-2034.
12. Christianson J.P., Jennings J.H., Ragole T., Flyer J.G., Benison A.M., Barth D.S., Watkins L.R., Maier S.F. Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis. Biol Psychiatry 2011, 70:458-464.
13. Cloez-Tayarani I., Cardona A., Rousselle J.C., Massot O., Edelman L., Fillion G. Autoradiographic characterization of [3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT1B receptors. Proc Natl Acad Sci USA 1997, 94:9899-9904.
14. Cloez-Tayarani I., Cardona A., Sarhan H., Rousselle J.C., Massot O., Edelman L., Fillion G. Mapping of 5-HT-moduline binding sites in guinea-pig brain by film and digital autoradiography. Brain Res 1998, 798:311-315.
15. Conrad K.L., Louderback K.M., Gessner C.P., Winder D.G. Stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis. Physiol Behav 2011, 104:248-256.
16. Costall B., Naylor R.J. 5-HT3 receptors. Curr Drug Targets CNS Neurol Disord 2004, 3:27-37.
17. Crayton J.W., Joshi I., Gulati A., Arora R.C., Wolf W.A. Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex. Brain Res 1996, 728:260-262.
18. Crestani C.C., Alves F.H., Correa F.M., Guimaraes F.S., Joca S.R. Acute reversible inactivation of the bed nucleus of stria terminalis induces antidepressant-like effect in the rat forced swimming test. Behav Brain Funct 2010, 6:30.
19. Dabrowska J., Rainnie D.G. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Neuroscience 2010, 171:721-733.
20. Davis M., Walker D.L., Miles L., Grillon C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 2010, 35:105-135.
21. De Olmos JS, Alheid GF, Beltramino CA (1985) Amygdala. In: The rat nervous system: forebrain and midbrain, vol. 1 (Paxinos G, ed). New york: Academic press., p. 223.
22. Dekeyne A., Mannoury la Cour C., Gobert A., Brocco M., Lejeune F., Serres F., Sharp T., Daszuta A., Soumier A., Papp M., Rivet J.M., Flik G., Cremers T.I., Muller O., Lavielle G., Millan M.J. S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology 2008, 199:549-568.
23. Delgado M., Caicoya A.G., Greciano V., Benhamu B., Lopez-Rodriguez M.L., Fernandez-Alfonso M.S., Pozo M.A., Manzanares J., Fuentes J.A. Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors. Eur J Pharmacol 2005, 511:9-19.
24. Dilts R.P., Boadle-Biber M.C. Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound. Neurosci Lett 1995, 199:78-80.
25. Dunn J.D. Plasma corticosterone responses to electrical stimulation of the bed nucleus of the stria terminalis. Brain Res 1987, 407:327-331.
26. Dunn J.D., Williams T.J. Cardiovascular responses to electrical stimulation of the bed nucleus of the stria terminalis. J Comp Neurol 1995, 352:227-234.
27. Farber L., Haus U., Spath M., Drechsler S. Physiology and pathophysiology of the 5-HT3 receptor. Scand J Rheumatol Suppl 2004, 119:2-8.
28. Ferguson S.M., Sandygren N.A., Neumaier J.F. Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine. Eur J Neurosci 2009, 30:1576-1584.
29. Fernandes C., McKittrick C.R., File S.E., McEwen B.S. Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. Psychoneuroendocrinology 1997, 22:477-491.
30. Ferretti C., Blengio M., Gamalero S.R., Ghi P. Biochemical and behaviour changes induced by acute stress in a chronic variate stress model of depression: the effect of amitriptyline. Eur J Pharmacol 1995, 280:19-26.
31. Forray M.I., Gysling K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis. Brain Res Brain Res Rev 2004, 47:145-160.
32. Funada M., Hara C. Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats. Brain Res 2001, 901:247-251.
33. Gomes F.V., Resstel L.B., Guimaraes F.S. The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors. Psychopharmacology 2011, 213:465-473.
34. Gordon J.A., Lacefield C.O., Kentros C.G., Hen R. State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice. J Neurosci 2005, 25:6509-6519.
35. Grahn R.E., Maswood S., McQueen M.B., Watkins L.R., Maier S.F. Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus. Behav Brain Res 1999, 99:153-167.
36. Grahn R.E., Will M.J., Hammack S.E., Maswood S., McQueen M.B., Watkins L.R., Maier S.F. Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res 1999, 826:35-43.
37. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 1995, 65:319-395.
38. Groenink L., van Bogaert M.J., van der Gugten J., Oosting R.S., Olivier B. 5-HT1A receptor and 5-HT1B receptor knockout mice in stress and anxiety paradigms. Behav Pharmacol 2003, 14:369-383.
39. Gross C., Santarelli L., Brunner D., Zhuang X., Hen R. Altered fear circuits in 5-HT(1A) receptor KO mice. Biol Psychiatry 2000, 48:1157-1163.
40. Guo J.D., Hammack S.E., Hazra R., Levita L., Rainnie D.G. Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes. Neuroscience 2009, 164:1776-1793.
41. Guo J.D., Rainnie D.G. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 2010, 165:1390-1401.
42. Guscott M., Bristow L.J., Hadingham K., Rosahl T.W., Beer M.S., Stanton J.A., Bromidge F., Owens A.P., Huscroft I., Myers J., Rupniak N.M., Patel S., Whiting P.J., Hutson P.H., Fone K.C., Biello S.M., Kulagowski J.J., McAllister G. Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression. Neuropharmacology 2005, 48:492-502.
43. Hammack S.E., Guo J.D., Hazra R., Dabrowska J., Myers K.M., Rainnie D.G. The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:1309-1320.
44. Hammack S.E., Mania I., Rainnie D.G. Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis. J Neurophysiol 2007, 98:638-656.
45. Harada K., Aota M., Inoue T., Matsuda R., Mihara T., Yamaji T., Ishibashi K., Matsuoka N. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Eur J Pharmacol 2006, 553:171-184.
46. Hazra R., Guo J.D., Ryan S.J., Jasnow A.M., Dabrowska J., Rainnie D.G. A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis. Mol Cell Neurosci 2011, 46:699-709.
47. Hedlund P.B. The 5-HT7 receptor and disorders of the nervous system: an overview. Psychopharmacology 2009, 206:345-354.
48. Hedlund P.B., Huitron-Resendiz S., Henriksen S.J., Sutcliffe J.G. 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern. Biol Psychiatry 2005, 58:831-837.
49. Heim C., Nemeroff C.B. Neurobiology of early life stress: clinical studies. Semin Clin Neuropsychiatry 2002, 7:147-159.
50. Heisler L.K., Zhou L., Bajwa P., Hsu J., Tecott L.H. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes Brain Behav 2007, 6:491-496.
51. Iyo A.H., Kieran N., Chandran A., Albert P.R., Wicks I., Bissette G., Austin M.C. Differential regulation of the serotonin 1 A transcriptional modulators five prime repressor element under dual repression-1 and nuclear-deformed epidermal autoregulatory factor by chronic stress. Neuroscience 2009, 163:1119-1127.
52. Ju G., Swanson L.W., Simerly R.B. Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: II. Chemoarchitecture. J Comp Neurol 1989, 280:603-621.
53. Katagiri H., Kagaya A., Nakae S., Morinobu S., Yamawaki S. Modulation of serotonin2A receptor function in rats after repeated treatment with dexamethasone and L-type calcium channel antagonist nimodipine. Prog Neuropsychopharmacol Biol Psychiatry 2001, 25:1269-1281.
54. Kieran N., Ou X.M., Iyo A.H. Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex. Neurosci Lett 2010, 469:380-384.
55. Kimura A., Stevenson P.L., Carter R.N., Maccoll G., French K.L., Paul Simons J., Al-Shawi R., Kelly V., Chapman K.E., Holmes M.C. Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity. Eur J Neurosci 2009, 30:299-306.
56. Kuwaki T. Orexin links emotional stress to autonomic functions. Auton Neurosci 2011, 161:20-27.
57. Lemonde S., Turecki G., Bakish D., Du L., Hrdina P.D., Bown C.D., Sequeira A., Kushwaha N., Morris S.J., Basak A., Ou X.M., Albert P.R. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003, 23:8788-8799.
58. Levita L., Hammack S.E., Mania I., Li X.Y., Davis M., Rainnie D.G. 5-Hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies. Neuroscience 2004, 128:583-596.
59. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
60. Lopez J.F., Chalmers D.T., Little K.Y., Watson S.J. A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol Psychiatry 1998, 43:547-573.
61. Lowry C.A. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol 2002, 14:911-923.
62. Lowry C.A., Rodda J.E., Lightman S.L., Ingram C.D. Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J Neurosci 2000, 20:7728-7736.
63. Lupien S.J., McEwen B.S., Gunnar M.R., Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 2009, 10:434-445.
64. Maier S.F., Watkins L.R. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev 2005, 29:829-841.
65. Maines L.W., Keck B.J., Smith J.E., Lakoski J.M. Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse 1999, 32:58-66.
66. Martin E.I., Ressler K.J., Jasnow A.M., Dabrowska J., Hazra R., Rainnie D.G., Nemeroff C.B., Owens M.J. A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biol Psychiatry 2010, 67:1212-1216.
67. McKittrick C.R., Blanchard D.C., Blanchard R.J., McEwen B.S., Sakai R.R. Serotonin receptor binding in a colony model of chronic social stress. Biol Psychiatry 1995, 37:383-393.
68. Millan M.J., Veiga S., Girardon S., Brocco M. Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes. Psychopharmacology 2003, 168:397-409.
69. Moberg C.A., Curtin J.J. Alcohol selectively reduces anxiety but not fear: startle response during unpredictable versus predictable threat. J Abnorm Psychol 2009, 118:335-347.
70. Morikawa H., Manzoni O.J., Crabbe J.C., Williams J.T. Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors. Mol Pharmacol 2000, 58:1271-1278.
71. Mullins U.L., Gianutsos G., Eison A.S. Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus. Neuropsychopharmacology 1999, 21:352-367.
72. Ossowska G., Nowa G., Kata R., Klenk-Majewska B., Danilczuk Z., Zebrowska-Lupina I. Brain monoamine receptors in a chronic unpredictable stress model in rats. J Neural Transm 2001, 108:311-319.
73. Ou X.M., Jafar-Nejad H., Storring J.M., Meng J.H., Lemonde S., Albert P.R. Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene. J Biol Chem 2000, 275:8161-8168.
74. Ou X.M., Storring J.M., Kushwaha N., Albert P.R. Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene. J Biol Chem 2001, 276:14299-14307.
75. Parks C.L., Robinson P.S., Sibille E., Shenk T., Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA 1998, 95:10734-10739.
76. Parks C.L., Shenk T. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem 1996, 271:4417-4430.
77. Peyron C., Petit J.M., Rampon C., Jouvet M., Luppi P.H. Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience 1998, 82:443-468.
78. Pietranera L., Saravia F.E., McEwen B.S., Lucas L.L., Johnson A.K., De Nicola A.F. Changes in Fos expression in various brain regions during deoxycorticosterone acetate treatment: relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor. Neuroendocrinology 2001, 74:396-406.
79. Rainnie DG, Guo J, Hazra R, Dabrowska J, Ressler KJ (2010) Characterization of the physiological and genetic phenotype of CRF expressing neuron in the bed nucleus of the stria terminalis. In: 40th annual meeting of society for neuroscience, San Diego, CA.
80. Roberts A.J., Krucker T., Levy C.L., Slanina K.A., Sutcliffe J.G., Hedlund P.B. Mice lacking 5-HT receptors show specific impairments in contextual learning. Eur J Neurosci 2004, 19:1913-1922.
81. Robinson O.J., Overstreet C., Allen P.S., Pine D.S., Grillon C. Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis?. Neuropsychopharmacology 2012, 37:1963-1971.
82. Savitz J., Lucki I., Drevets W.C. 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 2009, 88:17-31.
83. Shaikh M.B., Brutus M., Siegel H.E., Siegel A. Regulation of feline aggression by the bed nucleus of stria terminalis. Brain Res Bull 1986, 16:179-182.
84. Shepard J.D., Schulkin J., Myers D.A. Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duress. Behav Brain Res 2006, 174:193-196.
85. Sibille E., Hen R. Serotonin(1A) receptors in mood disorders: a combined genetic and genomic approach. Behav Pharmacol 2001, 12:429-438.
86. Singewald N., Kouvelas D., Kaehler S.T., Sinner C., Philippu A. Peripheral chemoreceptor activation enhances 5-hydroxytryptamine release in the locus coeruleus of conscious rats. Neurosci Lett 2000, 289:17-20.
87. Sink K.S., Walker D.L., Yang Y., Davis M. Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structures. J Neurosci 2011, 31:1802-1810.
88. Sleight A.J., Carolo C., Petit N., Zwingelstein C., Bourson A. Identification of 5-hydroxytryptamine7 receptor binding sites in rat hypothalamus: sensitivity to chronic antidepressant treatment. Mol Pharmacol 1995, 47:99-103.
89. Summers C.H., Kampshoff J.L., Ronan P.J., Lowry C.A., Prestbo A.A., Korzan W.J., Renner K.J. Monoaminergic activity in subregions of raphe nuclei elicited by prior stress and the neuropeptide corticotropin-releasing factor. J Neuroendocrinol 2003, 15:1122-1133.
90. Swanson L.W., Sawchenko P.E., Rivier J., Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 1983, 36:165-186.
91. Szewczyk B., Albert P.R., Burns A.M., Czesak M., Overholser J.C., Jurjus G.J., Meltzer H.Y., Konick L.C., Dieter L., Herbst N., May W., Rajkowska G., Stockmeier C.A., Austin M.C. Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharmacol 2009, 12:155-168.
92. Takao K., Nagatani T., Kitamura Y., Yamawaki S. Effects of corticosterone on 5-HT1A and 5-HT2 receptor binding and on the receptor-mediated behavioral responses of rats. Eur J Pharmacol 1997, 333:123-128.
93. Takase L.F., Nogueira M.I., Baratta M., Bland S.T., Watkins L.R., Maier S.F., Fornal C.A., Jacobs B.L. Inescapable shock activates serotonergic neurons in all raphe nuclei of rat. Behav Brain Res 2004, 153:233-239.
94. Vyas A., Bernal S., Chattarji S. Effects of chronic stress on dendritic arborization in the central and extended amygdala. Brain Res 2003, 965:290-294.
95. Walker D.L., Davis M. Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear. J Neurosci 1997, 17:9375-9383.
96. Walker D.L., Davis M. The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol Biochem Behav 2002, 71:379-392.
97. Walker D.L., Miles L.A., Davis M. Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:1291-1308.
98. Walker D.L., Toufexis D.J., Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 2003, 463:199-216.
99. Weisstaub N.V., Zhou M., Lira A., Lambe E., Gonzalez-Maeso J., Hornung J.P., Sibille E., Underwood M., Itohara S., Dauer W.T., Ansorge M.S., Morelli E., Mann J.J., Toth M., Aghajanian G., Sealfon S.C., Hen R., Gingrich J.A. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 2006, 313:536-540.
100. Xu Y., Zhang C., Wang R., Govindarajan S.S., Barish P.A., Vernon M.M., Fu C., Acharya A.P., Chen L., Boykin E., Yu J., Pan J., O'Donnell J.M., Ogle W.O. Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience 2011, 182:71-81.