Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors

European Journal of Pharmacology

Volumn 511, Issue 1, 2005, Pages 9-19

  Delgado, Mercedes ^a   Caicoya, Anne G ^a   Greciano, Virginia ^b   Benhamú, Bellinda ^c   López Rodríguez, María Luz ^c   Fernández Alfonso, María Soledad ^b   Pozo, Miguel A ^a   Manzanares, Jorge ^a,d   Fuentes, José A ^a,b  

^a INSTITUTO PLURIDISCIPLINAR   (Spain)

^b Facultad de Farmacia   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

5 HT1A receptor agonist; 5 HT2A receptor antagonist; 5 HT3 receptor antagonist; Anxiety; Serotonin

Indexed keywords

1 METHYL 3 INDAZOLECARBOXYLIC ACID N TROPANYLAMIDE; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2 METHYLSEROTONIN; 2 [[4 (NAPHTH 1 YL)PIPERAZIN 1 YL]METHYL] 1,4 DIOXOPERHYDROPYRROLO[1,2 A]PYRAZINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ADENYLATE CYCLASE; BUTACLAMOL; CINANSERIN; CSP 2503; DIAZEPAM; FLUNITRAZEPAM; FLUOXETINE; FORSKOLIN; KETANSERIN; LIGAND; PAROXETINE; PHENTOLAMINE; SEROTONIN 1 AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR; SPIPERONE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRADYCARDIA; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ELECTRIC ACTIVITY; ENZYME ACTIVITY; EXPERIMENTAL TEST; GENETIC TRANSFECTION; GUINEA PIG; HEAD TWITCH; HELA CELL; HUMAN; HUMAN CELL; HYPOTHALAMUS; ILEUM CONTRACTION; LIGHT DARK CYCLE; MALE; MOUSE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; RECTUM TEMPERATURE; REFLEX; SOCIAL INTERACTION; TRANQUILIZING ACTIVITY;

EID: 15044344529     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.01.032     Document Type: Article

References (40)

1. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
2. K. Bunce, M. Tyers, and P. Beranek Clinical evaluation of 5-HT3 receptor antagonists as anti-emetics Trends Pharmacol. Sci. 12 1991 46 48
3. G.F. Busatto, and R.W. Kerwin Perspectives on the role of serotonergic mechanisms in the pharmacology of schizophrenia J. Psychopharmacol. 11 1997 3 12
4. 50) of an enzymatic reaction Biochem. Pharmacol. 22 1973 3099 3108
5. B. Costall, and R.J. Naylor Anxiolytic effects of 5-HT3 antagonists in animals R.J. Rodgers S.J. Cooper 5-HT1A agonists, 5-HT3 antagonists and benzodiazepines, their comparative behavioural pharmacology 1991 CRC Boca Raton 133 157
6. B. Costall, and R.J. Naylor Neuropharmacology of 5-HT3 receptor ligands H.G. Baumgarten M. Göthert Serotoninergic neurons and 5-HT Receptors in the CNS 1997 Springer Berlin 409 438
7. B. Costall, and R.J. Naylor 5-HT3 receptors Curr. Drug Targets. CNS Neurol. Disord. 3 2004 27 37
8. J.N. Crawley, and F.K. Goodwin Preliminary report of a simple animal behavior model for the anxyolitic effects of benzodiazepines Pharmacol. Biochem. Behav. 13 1980 167 170
9. N.A. Darmani, and C.F. Gerdes Temporal differential adaptation of head-twitch and ear-scratch responses following administration of challenge doses of DOI Pharmacol. Biochem. Behav. 50 1995 545 550
10. N.A. Darmani, J. Shaddy, and C.F. Gerdes Differential ontogenesis of three DOI-induced behaviors in mice Physiol. Behav. 60 1996 1495 1500
11. J. De Vry 5-HT1A receptor agonists: recent developments and controversial issues Psychopharmacology (Berl.) 121 1995 1 26
12. W.C. Drevets, E. Frank, J.C. Price, D.J. Kupfer, D. Holt, P.J. Greer, Y. Huang, C. Gautier, and C. Mathis PET imaging of serotonin 1A receptor binding in depression Biol. Psychiatry 46 1999 1375 1387
13. S.E. File The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs J. Neurosci. Methods 2 1980 219 238
14. J. Fozard, and M. Host Selective inhibition of the von Bezold-Jarisch effect of 5-HT in the rat by antagonists of neuronal 5-HT receptors Br. J. Pharmacol. 77 1982 (520 pp.)
15. D.R. Gehlert, S.L. Gackenheimer, D.T. Wong, and D.W. Robertson Localization of 5-HT3 receptors in the rat brain using [3H]LY278584 Brain Res. 553 1991 149 154
16. G.M. Goodwin, R.J. De Souza, and A.R. Green The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). A model of presynaptic 5-HT1 function Neuropharmacology 24 1985 1187 1194
17. G. Griebel 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research Pharmacol. Ther. 65 1995 319 395
18. M. Hamon Neuropharmacology of anxiety: perspectives and prospects Trends Pharmacol. Sci. 15 1994 36 39
19. J.G. Hensler, R.C. Ferry, D.M. Labow, G.B. Kovachich, and A. Frazer Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus Synapse 17 1994 1 15
20. T. Jolas, R. Schreiber, A.M. Laporte, M. Chastanet, J. De Vry, T. Glaser, J. Adrien, and M. Hamon Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272 1995 920 929
21. S. Lemonde, G. Turecki, D. Bakish, L. Du, P.D. Hrdina, C.D. Bown, A. Sequeira, N. Kushwaha, S.J. Morris, A. Basak, X.M. Ou, and P.R. Albert Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide J. Neurosci. 23 2003 8788 8799
22. K.P. Lesch, Y. Zeng, A. Reif, and L. Gutknecht Anxiety-related traits in mice with modified genes of the serotonergic pathway Eur. J. Pharmacol. 480 2003 185 204
23. M.L. Lopez-Rodriguez, M.L. Rosado, B. Benhamu, M.J. Morcillo, E. Fernandez, and K.J. Schaper Synthesis and structure-activity relationships of a new model of arylpiperazines: 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models J. Med. Chem. 40 1997 1648 1656
24. M.L. Lopez-Rodriguez, B. Vicente, X. Deupi, S. Barrondo, M. Olivella, M.J. Morcillo, B. Behamu, J.A. Ballesteros, J. Salles, and L. Pardo Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor Mol. Pharmacol. 62 2002 15 21
25. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
26. T. Matsuda, P. Somboonthum, M. Suzuki, S. Asano, and A. Baba Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice Eur. J. Pharmacol. 280 1995 235 238
27. Y. Nagakura, M. Kadowaki, K. Tokoro, M. Tomoi, J. Mori, and M. Kohsaka Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist J. Pharmacol. Exp. Ther. 265 1993 752 758
28. A. Neumeister, E. Bain, A.C. Nugent, R.E. Carson, O. Bonne, D.A. Luckenbaugh, W. Eckelman, P. Herscovitch, D.S. Charney, and W.C. Drevets Reduced serotonin type 1A receptor binding in panic disorder J. Neurosci. 24 2004 589 591
29. D.H. Overstreet, R.C. Commissaris, G.R. De La, S.E. File, D.J. Knapp, and L.S. Seiden Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models Stress 6 2003 101 110
30. G. Patxinos, and C. Watson The rat brain in stereotaxic coordinates 1982 Academic Press London
31. P.J. Pauwels, P. Van Gompel, and J.E. Leysen Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells Biochem. Pharmacol. 45 1993 375 383
32. G. Pineyro, and P. Blier Autoregulation of serotonin neurons: role in antidepressant drug action Pharmacol. Rev. 51 1999 533 591
33. S.M. Sorensen, J.H. Kehne, G.M. Fadayel, T.M. Humphreys, H.J. Ketteler, C.K. Sullivan, V.L. Taylor, and C.J. Schmidt Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies J. Pharmacol. Exp. Ther. 266 1993 684 691
34. R.G.D. Steel, and J.H. Torrie Principles and procedures of statistics 1979 McGraw Hill New York
35. A. Strobel, L. Gutknecht, C. Rothe, A. Reif, R. Mossner, Y. Zeng, B. Brocke, and K.P. Lesch Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits J. Neural Transm. 110 2003 1445 1453
36. S. Sugita, K.Z. Shen, and R.A. North 5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala Neuron 8 1992 199 203
37. J. Tiihonen, A. Keski-Rahkonen, M. Lopponen, M. Muhonen, J. Kajander, T. Allonen, K. Nagren, J. Hietala, and A. Rissanen Brain serotonin 1A receptor binding in bulimia nervosa Biol. Psychiatry 55 2004 871 873
38. M. Toth 5-HT1A receptor knockout mouse as a genetic model of anxiety Eur. J. Pharmacol. 463 2003 177 184
39. J.H. Ye, R. Ponnudurai, and R. Schaefer Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders CNS Drug Rev. 7 2001 199 213
40. E. Zifa, and G. Fillion 5-Hydroxytryptamine receptors Pharmacol. Rev. 44 1992 401 458