Peripheral chemoreceptor activation enhances 5-hydroxytryptamine release in the locus coeruleus of conscious rats

Neuroscience Letters

Volumn 289, Issue 1, 2000, Pages 17-20

  Singewald, Nicolas ^a   Kouvelas, Dimitrios ^b   Kaehler, Stefan T ^a   Sinner, Catrin ^a   Philippu, Athineos ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

5 Hydroxytryptamine; Blood pressure; Chemoreflex; Cyanide; Push pull superfusion; Respiration; Sinoaortic denervation

Indexed keywords

POTASSIUM CYANIDE;

ANIMAL MODEL; ARTICLE; BREATHING RATE; CHEMORECEPTOR; CONTROLLED STUDY; LOCUS CERULEUS; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL;

ANIMALS; AROUSAL; BLOOD PRESSURE; CHEMORECEPTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LOCUS COERULEUS; MALE; POTASSIUM CYANIDE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; STEREOTAXIC TECHNIQUES; TIME FACTORS;

EID: 0034726018     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01241-6     Document Type: Article

References (21)

1. Coplan J.D., Lydiard R.B. Brain circuits in panic disorder. Biol. Psychiatry. 44:1998;1264-1276.
2. Elam M., Yao T., Thoren P., Svensson T.H. Hypercapnia and hypoxia: chemoreceptor -mediated control of locus coeruleus neurons and splanchnic, sympathetic nerves. Brain Res. 222:1981;373-381.
3. Erickson J.T., Millhorn D.E. Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J. Comp. Neurol. 348:1994;161-182.
4. Franchini K.G., Krieger E.M. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J. Autonom. Nerv. Syst. 42:1993;63-70.
5. Guyenet P.G., Koshiya N., Huangfu D., Verberne A.J.M., Riley T.A. Central respiratory control of A5 and A6 pontine noradrenergic neurons. Am. J. Physiol. 264:1993;R1035-R1044.
6. Haibara A.S., Colombari E., Chianca D.A., Bonagamba L.G.H., Machado B.H. NMDA receptors in NTS are involved in bradycardic but not pressor response of chemoreflex. Am. J. Physiol. 269:1995;H1421-H1427. in press.
7. Hayward L.F., Johnson A.K., Felder R.B. Arterial chemoreflex in conscious normotensive and hypertensive adult rats. Am. J. Physiol. 276:1999;H1215-H1222.
8. Hirooka Y., Polson J.W., Potts P.D., Dampney R.A. Hypoxia-induced Fos expression in neurons projecting to the pressor region in the rostral ventrolateral medulla. Neuroscience. 80:1997;1209-1224.
9. Kaehler S.T., Singewald N., Philippu A. The release of catecholamines in hypothalamus and locus coeruleus is modulated by peripheral chemoreceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 360:1999;428-434.
10. Kobayashi M., Cheng Z.B., Tanaka K., Nosaka S. Is the aortic depressor nerve involved in arterial chemoreflexes in rats? J. Autonom. Nerv. Syst. 78:1999;38-48.
11. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1998;Academic Press, Sydney.
12. 2-adrenoreceptors. Neurosci. Lett. 249:1998;37-40.
13. Pineda J., Aghajanian G.K. Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience. 77:1997;723-743.
14. 3 receptors in the nucleus tractus solitarii on the carotid chemoreflex. Am. J. Physiol. 272:1997;H1250-H1259.
15. Singewald N., Philippu A. Release of neurotransmitters in the locus coeruleus. Prog. Neurobiol. 56:1998;237-267.
16. Singewald N., Kaehler S.T., Hemeida R., Philippu A. Release of serotonin in the rat locus coeruleus: effects of cardiovascular, stressful and noxious stimuli. Eur. J. Neurosci. 9:1997;556-562.
17. Singewald N., Kaehler S.T., Hemeida R., Philippu A. Influence of excitatory amino acids on basal and sensory stimuli-induced release of 5-HT in the locus coeruleus. Br. J. Pharmacol. 123:1998;746-752.
18. Smoller J.W., Pollack M.H., Otto M.W., Rosenbaum J.F. Panic anxiety, dyspnea, and respiratory disease. Am. J. Respir. Crit. Care. Med. 154:1996;6-17.
19. Sun M.K., Reis D.J. Evidence that nitric oxide mediates the vasodepressor response to hypoxia in sino-denervated rats. Life Sci. 50:1992;555-565.
20. Van Bockstaele E.J., Peoples J., Telegan P. Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: evidence for a monosynaptic pathway. J. Comp. Neurol. 412:1999;410-428.
21. Vasquez E.C., Meyrelles S.S., Mauad H., Cabral A.M. Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex. Braz. J. Med. Biol. Res. 30:1997;521-532.