Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 230-239

  Kumar, Amit ^a   Wonganan, Piyanuch ^a   Sandoval, Michael A ^a   Li, Xinran ^a   Zhu, Saijie ^a   Cui, Zhengrong ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Antibodies response; Antigen gene expression; Cytokines; Skin permeation; Splenocyte proliferation

Indexed keywords

ANTIGEN GENES; ANTIGEN PRESENTING CELLS; CATIONIC NANOPARTICLES; CHARGED NANOPARTICLES; CYTOKINES; IMMUNE RESPONSE; IN-VITRO; IN-VIVO; INTRAMUSCULAR INJECTIONS; MICRONEEDLES; MUCOSAL IMMUNITY; PLASMID DNA; PLGA NANOPARTICLES; POSITIVELY CHARGED; SKIN PERMEATION; SPLENOCYTE PROLIFERATION; TRANSCUTANEOUS;

ANTIGENS; GENE EXPRESSION; IMMUNIZATION; IMMUNOLOGY; NANOPARTICLES; NEEDLES;

BIOMOLECULES;

CATION; NANOPARTICLE; PLASMID DNA; POLYGLACTIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IN VIVO STUDY; MICRONEEDLE MEDIATED TRANSCUTANEOUS IMMUNIZATION; MOUSE; MUCOSAL IMMUNITY; NEEDLE; NONHUMAN; PRIORITY JOURNAL; SKIN PERMEABILITY; SURFACE PROPERTY; TH1 CELL; TH2 CELL; UPREGULATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; BETA-GALACTOSIDASE; BONE MARROW CELLS; CELL LINE; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; DNA; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE TRANSFER TECHNIQUES; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LACTIC ACID; MICE; MICE, HAIRLESS; MICE, INBRED BALB C; MICE, INBRED C57BL; NANOPARTICLES; NEEDLES; PLASMIDS; POLYGLYCOLIC ACID; QUATERNARY AMMONIUM COMPOUNDS; SPLEEN;

EID: 84866662937     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.011     Document Type: Article

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