Does iron inhibit calcification during atherosclerosis?

Free Radical Biology and Medicine

Volumn 53, Issue 9, 2012, Pages 1675-1679

  Rajendran, Reshmi ^a   Minqin, Ren ^a   Ronald, John A ^b   Rutt, Brian K ^b   Halliwell, Barry ^a   Watt, Frank ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Atherosclerosis; Calcium; Free radicals; Iron; PIXE; RBS; STIM

Indexed keywords

CALCIUM; IRON;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; DISEASE COURSE; MALE; NONHUMAN; OXIDATIVE STRESS; PARTICLE INDUCED X RAY EMISSION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABBIT; RUTHERFORD BACKSCATTERING SPECTROMETRY; SCANNING TRANSMISSION ION MICROSCOPY; STAINING; TISSUE FIXATION;

ANIMALS; AORTA; ATHEROSCLEROSIS; CALCIUM; DIET, HIGH-FAT; IRON; MALE; ORGAN SPECIFICITY; PLAQUE, ATHEROSCLEROTIC; RABBITS; SPECTROMETRY, X-RAY EMISSION; VASCULAR CALCIFICATION;

ORYCTOLAGUS CUNICULUS;

EID: 84866662687     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.014     Document Type: Article

References (23)

1. S. Fu, M.J. Davies, R. Stocker, and R.T. Dean Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque Biochem. J. 333 1998 519 525
2. B. Halliwell, and J.M.C. Gutteridge Free Radicals in Biology and Medicine 4th edition 2007 Oxford University Press London
3. S. Chrissobolis, and F.M. Faraci The role of oxidative stress and NADPH oxidase in cerebrovascular disease Trends Mol. Med. 14 2008 495 502
4. N. Mody, F. Parhami, T.A. Sarafin, and L.L. Demer Oxidative stress modulates osteoblastic differentiation of vascular and bone cells Free Radic. Biol. Med. 31 2001 509 519
5. C.H. Byon, A. Javed, Q. Dai, J.C. Kappes, T.L. Clemens, V.M. Darley-Usmar, J.M. McDonald, and Y. Chen Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signalling J. Biol. Chem. 283 2008 15319 15327
6. F.T. Tang, S.R. Chen, X.Q. Wu, T.Q. Wang, J.W. Chen, J. Li, L.P. Bao, H.Q. Huang, and P.Q. Liu Hypercholesterolemia accelerates vascular calcification induced by excessive vitamin D via oxidative stress Calcif. Tissue Int. 79 2006 326 339
7. S.J. Daley, K.F. Klemp, J.R. Guyton, and K.A. Rogers Cholesterol fed and casein fed rabbit models of atherosclerosis. Part 2. Differing morphological severity of atherogenesis despite matched plasma cholesterol levels Arterioscler. Thromb. 14 1994 105 141
8. F. Watt, R. Rajendran, M.Q. Ren, B.K.H. Tan, and B. Halliwell A nuclear microscopy study of trace elements Ca, Fe, Zn and Cu in atherosclerosis Nucl. Instrum. Methods Phys. Res. B 249 2006 646 662
9. C.W. Adams, N. Miller, R.S. Morgan, and S.N. Rao Lipoprotein levels and tissue lipids in fatty-fibrous atherosclerosis induced in rabbits by two years cholesterol feeding at a low level Atherosclerosis 44 1982 1 8
10. J.A. Ronald, M.S.R. Walcarius, J.F. Robinson, R.A. Hegele, B.K. Rutt, and K.A. Rogers MRI of early and late stage arterial remodelling in a low level cholesterol-fed rabbit model of atherosclerosis J. Magn. Reson. Imaging 26 2007 1010 1019
11. G. Finking, and H. Hanke Nikolaj Nikolajewitsch Anitschkow (1885-1964) established the cholesterol-fed rabbit as a model for atherosclerosis research Atherosclerosis 135 1997 1 7
12. L.R. Doolittle A semiautomatic algorithm for Rutherford backscattering analysis Nucl. Instrum. Methods Phys. Res. B 15 1986 227 231
13. S.A.E. Johansson, J.L. Campbell, and K.G. Malmqvist Particle Induced X-ray Emission Spectrometry (PIXE) 1995 Wiley London
14. Mayer, M. SIMNRA Users Guide Technical Report IPP 9/113. Garching, Germany: Max-Planck-Insitut fur Plasmaphysik; 1996.
15. J.A. Maxwell, J.L. Campbell, and W.J. Tesdale The Guelph PIXE software package Nucl. Instrum. Methods Phys. Res. B 43 1988
16. H.Z. Jerrold Biostatistical Analysis 1984 Prentice Hall Upper Saddle River, NJ
17. M.Q. Ren, F. Watt, B.K.H. Tan, and B. Halliwell Correlation of iron and zinc levels with lesion depth in newly formed atherosclerotic lesions Free Radic. Biol. Med. 34 2003 746 752
18. H. Kudo, S. Suzuki, A. Watanabe, H. Kikuch, S. Sassa, and S. Sakamoto Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats Toxicology 246 2008 143 147
19. L.F. Huitmea, P.R. van Weeren, A. Barneveld, C.H. van de Lest, J.B. Helms, and A.B. Vaandrager Iron derived from the nitric oxide donor sodium nitroprusside inhibits mineralization Eur. J. Pharmacol. 542 2006 48 53
20. M.Q. Ren, R. Rajendran, P. Ning, B.K.H. Tan, W.-Y. Ong, F. Watt, and B. Halliwell The iron chelator desferioxamine inhibits atherosclerotic lesion development and decreases lesion iron concentrations in the cholesterol-fed rabbit Free Radic. Biol. Med. 38 2005 1206 1211
21. O. Saeed, F. Otsuka, R. Polavarapu, V. Karmali, D. Weiss, T. Davis, B. Rostad, K. Pachura, L. Adams, J. Elliott, W.R. Taylor, J. Narula, F. Kolodgie, R. Virmani, C.C. Hong, and A.V. Finn Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 32 2012 299 307
22. 2 channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy Nat. Med. 9 2003 1187 1194
23. 2 channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1 Nat. Med. 13 2007 448 454