Correlation of iron and zinc levels with lesion depth in newly formed atherosclerotic lesions

Free Radical Biology and Medicine

Volumn 34, Issue 6, 2003, Pages 746-752

  Minqin, Ren ^a   Watt, Frank ^a   Huat, Benny Tan Kwong ^a   Halliwell, Barry ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Atherosclerosis; Free radicals; Iron; Iron chelator desferal; Lesion size; Nuclear microscopy

Indexed keywords

DEFEROXAMINE MESYLATE; IRON; IRON CHELATING AGENT; ZINC;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; CONTROLLED STUDY; CORRELATION ANALYSIS; IRON CHELATION; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RABBIT; SCANNING TRANSMISSION ELECTRON MICROSCOPY; SPECTROMETRY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0037443734     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01427-2     Document Type: Article

References (23)

1. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340:1999;115-126.
2. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 321:1989;1196-1197.
3. Parthasarathy S., Santanam N., Ramachandran S., Meilhac O. Potential role of oxidized lipids and lipoproteins in antioxidant defense. Free Radic. Res. 33:2000;197-215.
4. Dean R.T. Beyond Schuh early studies on the oxidation of LDL and other lipoproteins and its role in atherosclerosis . Redox Rep. 5:2000;251-255.
5. Smith C., Mitchinson M.J., Aruoma O.I., Halliwell B. Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. Biochem. J. 286:1992;901-905.
6. Sullivan J.L. The iron paradigm of ischemic heart disease. Am. Heart J. 117:1989;1177-1188.
7. Ponka P., Beaumont C., Richardson D.R. Function and regulation of transferrin and ferritin. Semin. Hematol. 35:1998;35-54.
8. Salonen J.T., Korpela H., Nyyssonen K., Porkkala E., Tuomainen T.P., Belcher J.D., Jacobs D.R. Jr., Salonen R. Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins a randomized cross-over trial in male smokers . J. Intern. Med. 237:1995;161-168.
9. Rossi E., McQuillan B.M., Hung J., Thompson P.L., Kuek C., Beilby J.P. Serum ferritin and C282Y mutation in the hemochromatosis gene as predictors of asymptomatic carotid atherosclerosis in a community population. Stroke. 31:2000;3015-3020.
10. Danesh J., Appleby P. Coronary heart disease and iron status meta-analysis of prospective studies . Circulation. 99:1999;852-854.
11. Halliwell B., Gutteridge J.M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219:1984;1-14.
12. Halliwell B., Gutteridge J.M. Free radicals in biology and medicine. 1999;Oxford University Press, New York.
13. Ponraj D., Makjanic J., Thong P.S.P., Tan B.K.H., Watt F. The onset of atherosclerotic lesion formation in hypercholesterolemic rabbits is delayed by iron depletion. FEBS Lett. 459:1999;218-222.
14. Hennig B., Toborek M., McClain C.J. Antiatherogenic properties of zinc implications in endothelial cell metabolism . Nutrition. 12:1996;711-717.
15. Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant. Free Radic. Biol. Med. 8:1990;281-291.
16. Halliwell B. Protection against tissue damage in vivo by desferrioxamine what is its mechanism of action . Free Radic. Biol. Med. 7:1989;645-651.
17. Horwitz L.D., Rosenthal E.A. Iron-mediated cardiovascular injury. Vasc. Med. 4:1999;93-99.
18. Sullivan J.L. Stored iron and myocardial perfusion deficits. Am. Heart J. 143:2002;193-195.
19. Sanan S., Sharma G., Malhotra R., Sanan D.P., Jain P., Vadhera P. Protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic phase of clinical haemorrhagic shock in dogs correlation with improved survival rate and recovery . Free Radic. Res. Commun. 6:1989;29-38.
20. Persijin J.P., van der Slik W., Riethorst A. Determination of serum iron and latent iron-binding capacity (LIBC). Clin. Chim. Acta. 35:1971;91-98.
21. Drabkin D.L., Austin J.H. Spectrophotometric studies, II preparation from washed blood cells; nitric oxide, hemoglobin and sulfhemoglobin . J. Biol. Chem. 112:1935;51-65.
22. Siedel J., Hagele E.O., Wahlefeld A.W. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin. Chem. 29:1983;1075-1080.
23. Watt F., Orlic I., Loh K.K., Sow C.H., Thong P., Liew S.C., Osipowicz T., Choo T.F., Tang S.M. The National University of Singapore nuclear microscopy facility. Nucl. Instrum. Methods. B85:1994;708-715.