The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2

Chemistry and Biology

Volumn 19, Issue 9, 2012, Pages 1093-1104

  Polier, Gernot ^a   Neumann, Jennifer ^a   Thuaud, Frédéric ^b   Ribeiro, Nigel ^b   Gelhaus, Christoph ^c   Schmidt, Hendrik ^c   Giaisi, Marco ^a   Köhler, Rebecca ^a   Müller, Wolfgang W ^a   Proksch, Peter ^d   Leippe, Matthias ^c   Janssen, Ottmar ^c   Désaubry, Laurent ^b   Krammer, Peter H ^a   Li Weber, Min ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Faculté de Pharmacie   (France)

^c UNIVERSITY OF KIEL   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D3; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROHIBITIN; PROHIBITIN 1; PROHIBITIN 2; RAF PROTEIN; ROCAGLAMIDE; SERINE; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

AGLAIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOFURANS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HELA CELLS; HUMANS; JURKAT CELLS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; PROTO-ONCOGENE PROTEINS C-RAF; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866661335     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.07.012     Document Type: Article

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