-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBOJ 15:6541-6551.
-
(1996)
EMBOJ
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
1942502268
-
Human skeletal muscle cell differentiation is associated with changes in myogenic markers and enhanced insulin-mediated MAPK and PKB phosphorylation
-
Al-Khalili L, Kramer D, Wretenberg P, Krook A. 2004. Human skeletal muscle cell differentiation is associated with changes in myogenic markers and enhanced insulin-mediated MAPK and PKB phosphorylation. Acta Physiol Scand 180:395-403.
-
(2004)
Acta Physiol Scand
, vol.180
, pp. 395-403
-
-
Al-Khalili, L.1
Kramer, D.2
Wretenberg, P.3
Krook, A.4
-
3
-
-
0036544519
-
Muscle-specific expression of insulin-like growth factor 1 counters muscle decline in mdx mice
-
Barton ER, Morris L, Musaro A, Rosenthal N, Sweeney HL. 2002. Muscle-specific expression of insulin-like growth factor 1 counters muscle decline in mdx mice. J Cell Biol 157:137-148.
-
(2002)
J Cell Biol
, vol.157
, pp. 137-148
-
-
Barton, E.R.1
Morris, L.2
Musaro, A.3
Rosenthal, N.4
Sweeney, H.L.5
-
4
-
-
33745668478
-
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
-
Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR. 2006. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab 4:89-96.
-
(2006)
Cell Metab
, vol.4
, pp. 89-96
-
-
Bouzakri, K.1
Zachrisson, A.2
Al-Khalili, L.3
Zhang, B.B.4
Koistinen, H.A.5
Krook, A.6
Zierath, J.R.7
-
5
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil DP, Hemmings BA. 2001. Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci 26:657-664.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
6
-
-
0033515625
-
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
-
Brodbeck D, Cron P, Hemmings BA. 1999. A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 274:9133-9136.
-
(1999)
J Biol Chem
, vol.274
, pp. 9133-9136
-
-
Brodbeck, D.1
Cron, P.2
Hemmings, B.A.3
-
7
-
-
0032578915
-
Induction of Akt-2 correlates with differentiation in Sol8 muscle cells
-
Calera MR, Pilch PF. 1998. Induction of Akt-2 correlates with differentiation in Sol8 muscle cells. Biochem Biophys Res Commun 251:835-841.
-
(1998)
Biochem Biophys Res Commun
, vol.251
, pp. 835-841
-
-
Calera, M.R.1
Pilch, P.F.2
-
8
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15:2203-2208.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
9
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. 1992. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 89:9267-9271.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
Tsichlis, P.N.7
Testa, J.R.8
-
10
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. 2001a. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276:38349-38352.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
11
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB III, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. 2001b. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292:1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
12
-
-
0034680931
-
Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA
-
Delage-Mourroux R, Martini PG, Choi I, Kraichely DM, Hoeksema J, Katzenellenbogen BS. 2000. Analysis of estrogen receptor interaction with a repressor of estrogen receptor activity (REA) and the regulation of estrogen receptor transcriptional activity by REA. J Biol Chem 275:35848-35856.
-
(2000)
J Biol Chem
, vol.275
, pp. 35848-35856
-
-
Delage-Mourroux, R.1
Martini, P.G.2
Choi, I.3
Kraichely, D.M.4
Hoeksema, J.5
Katzenellenbogen, B.S.6
-
13
-
-
0029907306
-
Growth hormone and the insulin-like growth factor system in myogenesis
-
Florini JR, Ewton DZ, Coolican SA. 1996. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr Rev 17:481-517.
-
(1996)
Endocr Rev
, vol.17
, pp. 481-517
-
-
Florini, J.R.1
Ewton, D.Z.2
Coolican, S.A.3
-
14
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG. 2003. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 112:197-208.
-
(2003)
J Clin Invest
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
15
-
-
0031782480
-
Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
-
Hajduch E, Alessi DR, Hemmings BA, Hundal HS. 1998. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47:1006-1013.
-
(1998)
Diabetes
, vol.47
, pp. 1006-1013
-
-
Hajduch, E.1
Alessi, D.R.2
Hemmings, B.A.3
Hundal, H.S.4
-
16
-
-
33750980971
-
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding
-
Heron-Milhavet L, Franckhauser C, Rana V, Berthenet C, Fisher D, Hemmings BA, Fernandez A, Lamb NJ. 2006. Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol 26:8267-8280.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8267-8280
-
-
Heron-Milhavet, L.1
Franckhauser, C.2
Rana, V.3
Berthenet, C.4
Fisher, D.5
Hemmings, B.A.6
Fernandez, A.7
Lamb, N.J.8
-
17
-
-
0026270993
-
Molecular cloning of a second form of rac protein kinase
-
Jones PF, Jakubowicz T, Hemmings BA. 1991. Molecular cloning of a second form of rac protein kinase. Cell Regul 2:1001-1009.
-
(1991)
Cell Regul
, vol.2
, pp. 1001-1009
-
-
Jones, P.F.1
Jakubowicz, T.2
Hemmings, B.A.3
-
18
-
-
0037189574
-
Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter
-
Kaneko S, Feldman RI, Yu L, Wu Z, Gritsko T, Shelley SA, Nicosia SV, Nobori T, Cheng JQ. 2002. Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter. J Biol Chem 277:23230-23235.
-
(2002)
J Biol Chem
, vol.277
, pp. 23230-23235
-
-
Kaneko, S.1
Feldman, R.I.2
Yu, L.3
Wu, Z.4
Gritsko, T.5
Shelley, S.A.6
Nicosia, S.V.7
Nobori, T.8
Cheng, J.Q.9
-
19
-
-
33845970253
-
Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2
-
Kasashima K, Ohta E, Kagawa Y, Endo H. 2006. Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. J Biol Chem 281:36401-36410.
-
(2006)
J Biol Chem
, vol.281
, pp. 36401-36410
-
-
Kasashima, K.1
Ohta, E.2
Kagawa, Y.3
Endo, H.4
-
20
-
-
0032555944
-
The muscle regulatory factors MyoD and myf-5 undergo distinct cell cycle-specific expression in muscle cells
-
Kitzmann M, Carnac G, Vandromme M, Primig M, Lamb NJ, Fernandez A. 1998. The muscle regulatory factors MyoD and myf-5 undergo distinct cell cycle-specific expression in muscle cells. J Cell Biol 142:1447-1459.
-
(1998)
J Cell Biol
, vol.142
, pp. 1447-1459
-
-
Kitzmann, M.1
Carnac, G.2
Vandromme, M.3
Primig, M.4
Lamb, N.J.5
Fernandez, A.6
-
21
-
-
2642511664
-
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases
-
Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. 2004. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem 279:24834-24843.
-
(2004)
J Biol Chem
, vol.279
, pp. 24834-24843
-
-
Kurtev, V.1
Margueron, R.2
Kroboth, K.3
Ogris, E.4
Cavailles, V.5
Seiser, C.6
-
22
-
-
0030727172
-
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
-
Meier R, Alessi DR, Cron P, Andjelkovic M, Hemmings BA. 1997. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem 272:30491-30497.
-
(1997)
J Biol Chem
, vol.272
, pp. 30491-30497
-
-
Meier, R.1
Alessi, D.R.2
Cron, P.3
Andjelkovic, M.4
Hemmings, B.A.5
-
23
-
-
0030219748
-
Defining the regulatory networks for muscle development
-
Molkentin JD, Olson EN. 1996. Defining the regulatory networks for muscle development. Curr Opin Genet Dev 6:445-453.
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 445-453
-
-
Molkentin, J.D.1
Olson, E.N.2
-
24
-
-
0033536054
-
An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
-
Montano MM, Ekena K, DeJage-Mourroux R, Chang W, Martini P, Katzenelfenbogen BS. 1999. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. Proc Natl Acad Sci USA 96:6947-6952.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6947-6952
-
-
Montano, M.M.1
Ekena, K.2
DeJage-Mourroux, R.3
Chang, W.4
Martini, P.5
Katzenelfenbogen, B.S.6
-
25
-
-
0036161635
-
The mitochondrial PHB complex: Roles in mitochondrial respiratory complex assembly, ageing and degenerative disease
-
Nijtmans LG, Artal SM, Grivell LA, Coates PJ. 2002. The mitochondrial PHB complex: Roles in mitochondrial respiratory complex assembly, ageing and degenerative disease. Cell Mol Life Sci 59:143-155.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 143-155
-
-
Nijtmans, L.G.1
Artal, S.M.2
Grivell, L.A.3
Coates, P.J.4
-
26
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. 2003. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2, Genes Dev 17:1352-1365.
-
(2003)
Genes Dev
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
Xu, P.Z.2
Chen, M.L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
Sundararajan, D.7
Chen, W.S.8
Crawford, S.E.9
Coleman, K.G.10
Hay, N.11
-
27
-
-
4644352422
-
Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy
-
Rochat A, Fernandez A, Vandromme M, Moles JP, Bouschet T, Carnac G, Lamb NJ. 2004. Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell 15:4544-4555.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4544-4555
-
-
Rochat, A.1
Fernandez, A.2
Vandromme, M.3
Moles, J.P.4
Bouschet, T.5
Carnac, G.6
Lamb, N.J.7
-
28
-
-
0037862006
-
Unravelling the activation mechanisms of protein kinase B/Akt
-
Scheid MP, Woodgett JR. 2003. Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 546:108-112.
-
(2003)
FEBS Lett
, vol.546
, pp. 108-112
-
-
Scheid, M.P.1
Woodgett, J.R.2
-
29
-
-
0036173144
-
Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts
-
Sumitani S, Goya K, Testa JR, Kouhara H, Kasayama S. 2002. Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts. Endocrinology 143:820-828.
-
(2002)
Endocrinology
, vol.143
, pp. 820-828
-
-
Sumitani, S.1
Goya, K.2
Testa, J.R.3
Kouhara, H.4
Kasayama, S.5
-
30
-
-
4344575079
-
Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
-
Sun L, Liu L, Yang XJ, Wu Z. 2004. Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J Cell Sci 117:3021-3029.
-
(2004)
J Cell Sci
, vol.117
, pp. 3021-3029
-
-
Sun, L.1
Liu, L.2
Yang, X.J.3
Wu, Z.4
-
31
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, Frahm J, Hemmings BA. 2005. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132:2943-2954.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
32
-
-
0035914338
-
Insulin-like growth factor-mediated muscle differentiation: Collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenin
-
Tureckova J, Wilson EM, Cappalonga JL, Rotwein P. 2001. Insulin-like growth factor-mediated muscle differentiation: Collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenin. J Biol Chem 276:39264-39270.
-
(2001)
J Biol Chem
, vol.276
, pp. 39264-39270
-
-
Tureckova, J.1
Wilson, E.M.2
Cappalonga, J.L.3
Rotwein, P.4
-
33
-
-
0032570815
-
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
-
Ueki K, Yamamoto-Honda R, Kaburagi Y, Yamauchi T, Tobe K, Burgering BM, Coffer PJ, Komuro I, Akanuma Y, Yazaki Y, Kadowaki T. 1998. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem 273:5315-5322.
-
(1998)
J Biol Chem
, vol.273
, pp. 5315-5322
-
-
Ueki, K.1
Yamamoto-Honda, R.2
Kaburagi, Y.3
Yamauchi, T.4
Tobe, K.5
Burgering, B.M.6
Coffer, P.J.7
Komuro, I.8
Akanuma, Y.9
Yazaki, Y.10
Kadowaki, T.11
-
34
-
-
0026727855
-
Serum response factor p67SRF is expressed and required during myogenic differentiation of both mouse C2 and rat L6 muscle cell lines
-
Vandromme M, Gauthier-Rouviere C, Carnac G, Lamb N, Fernandez A. 1992. Serum response factor p67SRF is expressed and required during myogenic differentiation of both mouse C2 and rat L6 muscle cell lines. J Cell Biol 118:1489-1500.
-
(1992)
J Cell Biol
, vol.118
, pp. 1489-1500
-
-
Vandromme, M.1
Gauthier-Rouviere, C.2
Carnac, G.3
Lamb, N.4
Fernandez, A.5
-
35
-
-
0035896630
-
Protein kinase B beta/Akt2 plays a specific role in muscle differentiation
-
Vandromme M, Rochat A, Meier R, Carnac G, Besser D, Hemmings BA, Fernandez A, Lamb NJ. 2001. Protein kinase B beta/Akt2 plays a specific role in muscle differentiation. J Biol Chem 276:8173-8179.
-
(2001)
J Biol Chem
, vol.276
, pp. 8173-8179
-
-
Vandromme, M.1
Rochat, A.2
Meier, R.3
Carnac, G.4
Besser, D.5
Hemmings, B.A.6
Fernandez, A.7
Lamb, N.J.8
-
36
-
-
0037028209
-
Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression
-
Wang S, Fusaro G, Padmanabhan J, Chellappan SP. 2002. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene 21:8388-8396.
-
(2002)
Oncogene
, vol.21
, pp. 8388-8396
-
-
Wang, S.1
Fusaro, G.2
Padmanabhan, J.3
Chellappan, S.P.4
-
37
-
-
34247171304
-
Selective control of muscle differentiation by Akt
-
Wilson EM, Rotwein P. 2007. Selective control of muscle differentiation by Akt. J Biol Chem 282:5106-5110.
-
(2007)
J Biol Chem
, vol.282
, pp. 5106-5110
-
-
Wilson, E.M.1
Rotwein, P.2
-
38
-
-
0742305350
-
Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation
-
Wilson EM, Tureckova J, Rotwein P. 2004. Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation. Mol Biol Cell 15:497-505.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 497-505
-
-
Wilson, E.M.1
Tureckova, J.2
Rotwein, P.3
-
39
-
-
0042357084
-
Protein kinase B alpha/Akt1 regulates placental development and fetal growth
-
Yang ZZ, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings BA. 2003. Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem 278:32124-32131.
-
(2003)
J Biol Chem
, vol.278
, pp. 32124-32131
-
-
Yang, Z.Z.1
Tschopp, O.2
Hemmings-Mieszczak, M.3
Feng, J.4
Brodbeck, D.5
Perentes, E.6
Hemmings, B.A.7
|