메뉴 건너뛰기




Volumn 125, Issue 18, 2012, Pages 3312-3317

Type 2 epithelial mesenchymal transition in vivo: Truth or pitfalls?

Author keywords

Epithelial mesenchymal transition; Fibroblast; Tissue fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; AQUAPORIN; CALVASCULIN; CLAUDIN 2; CYTOKERATIN; DESMIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; HEAT SHOCK PROTEIN 47; INTEGRIN LINKED KINASE; PROTEIN ZO1; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

EID: 84866648876     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2012.18.021     Document Type: Article
Times cited : (11)

References (31)
  • 1
    • 0034112481 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    • Strutz F, Zeisberg M, Hemmerlein B, Sattler B, Hummel K, Becker V, et al. Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int 2000; 57: 1521-1538.
    • (2000) Kidney Int , vol.57 , pp. 1521-1538
    • Strutz, F.1    Zeisberg, M.2    Hemmerlein, B.3    Sattler, B.4    Hummel, K.5    Becker, V.6
  • 2
    • 33845973760 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats
    • Broekema M, Harmsen MC, van Luyn MJ, Koerts JA, Petersen AH, van Kooten TG, et al. Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J Am Soc Nephrol 2007; 18: 165-175.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 165-175
    • Broekema, M.1    Harmsen, M.C.2    van Luyn, M.J.3    Koerts, J.A.4    Petersen, A.H.5    van Kooten, T.G.6
  • 3
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 2006; 103: 13180-13185.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6
  • 4
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 2009; 119: 1438-1449.
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 5
    • 84863183146 scopus 로고    scopus 로고
    • New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis
    • Lee K, Nelson CM. New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int Rev Cell Mol Biol 2012; 294: 171-221.
    • (2012) Int Rev Cell Mol Biol , vol.294 , pp. 171-221
    • Lee, K.1    Nelson, C.M.2
  • 6
    • 84856706398 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers
    • Lomas NJ, Watts KL, Akram KM, Forsyth NR, Spiteri MA. Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers. Int J Clin Exp Pathol 2012; 5: 58-71.
    • (2012) Int J Clin Exp Pathol , vol.5 , pp. 58-71
    • Lomas, N.J.1    Watts, K.L.2    Akram, K.M.3    Forsyth, N.R.4    Spiteri, M.A.5
  • 7
    • 84865805629 scopus 로고    scopus 로고
    • Induction of a mesenchymal expression program in lung epithelial cells by Wnt/beta-catenin requires the presence of c-Jun N-terminal kinase 1
    • Epub ahead of print
    • van der Velden JL, Guala AS, Leggett SE, Sluimer J, Badura EC, Janssen-Heininger YM. Induction of a mesenchymal expression program in lung epithelial cells by Wnt/beta-catenin requires the presence of c-Jun N-terminal kinase 1. Am J Respir Cell Mol Biol 2012; Epub ahead of print.
    • (2012) Am J Respir Cell Mol Biol
    • van der Velden, J.L.1    Guala, A.S.2    Leggett, S.E.3    Sluimer, J.4    Badura, E.C.5    Janssen-Heininger, Y.M.6
  • 8
    • 67650752133 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    • Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009; 180: 122-133.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 122-133
    • Hackett, T.L.1    Warner, S.M.2    Stefanowicz, D.3    Shaheen, F.4    Pechkovsky, D.V.5    Murray, L.A.6
  • 9
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005; 166: 1321-1332.
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    du Bois, R.M.6
  • 10
    • 77953769774 scopus 로고    scopus 로고
    • Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    • Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010; 285: 20202-20212.
    • (2010) J Biol Chem , vol.285 , pp. 20202-20212
    • Flier, S.N.1    Tanjore, H.2    Kokkotou, E.G.3    Sugimoto, H.4    Zeisberg, M.5    Kalluri, R.6
  • 11
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007; 282: 23337-23347.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 12
    • 73949096744 scopus 로고    scopus 로고
    • Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    • Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176: 85-97.
    • (2010) Am J Pathol , vol.176 , pp. 85-97
    • Humphreys, B.D.1    Lin, S.L.2    Kobayashi, A.3    Hudson, T.E.4    Nowlin, B.T.5    Bonventre, J.V.6
  • 13
    • 77956158103 scopus 로고    scopus 로고
    • Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice
    • Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, et al. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 2010; 139: 987-998.
    • (2010) Gastroenterology , vol.139 , pp. 987-998
    • Scholten, D.1    Osterreicher, C.H.2    Scholten, A.3    Iwaisako, K.4    Gu, G.5    Brenner, D.A.6
  • 14
    • 84874435425 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte pulmonary fibrosis
    • Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, et al. Lineage tracing demonstrates no evidence of cholangiocyte pulmonary fibrosis. Annu Rev Physiol 2011; 73: 413-435.
    • (2011) Annu Rev Physiol , vol.73 , pp. 413-435
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6
  • 15
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 16
    • 78649436817 scopus 로고    scopus 로고
    • Contribution of epithelial plasticity to renal transplantation-associated fibrosis
    • Hertig A, Flier SN, Kalluri R. Contribution of epithelial plasticity to renal transplantation-associated fibrosis. Transplant Proc 2010; 42 (9 Suppl): S7-S12.
    • (2010) Transplant Proc , vol.42 , Issue.9 SUPPL.
    • Hertig, A.1    Flier, S.N.2    Kalluri, R.3
  • 17
    • 84860531411 scopus 로고    scopus 로고
    • V-ATPase promotes transforming growth factor-beta-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells
    • Cao X, Yang Q, Qin J, Zhao S, Li X, Fan J, et al. V-ATPase promotes transforming growth factor-beta-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells. Am J Physiol Renal Physiol 2012; 302: F1121-F1132.
    • (2012) Am J Physiol Renal Physiol , vol.302
    • Cao, X.1    Yang, Q.2    Qin, J.3    Zhao, S.4    Li, X.5    Fan, J.6
  • 18
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15: 1-12.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 19
    • 84859413955 scopus 로고    scopus 로고
    • Role of TGF-beta in chronic kidney disease: An integration of tubular, glomerular and vascular effects
    • Lopez-Hernandez FJ, Lopez-Novoa JM. Role of TGF-beta in chronic kidney disease: an integration of tubular, glomerular and vascular effects. Cell Tissue Res 2012; 347: 141-154.
    • (2012) Cell Tissue Res , vol.347 , pp. 141-154
    • Lopez-Hernandez, F.J.1    Lopez-Novoa, J.M.2
  • 20
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005; 6: 56.
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 21
    • 36148956552 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells
    • Kim JH, Jang YS, Eom KS, Hwang YI, Kang HR, Jang SH, et al. Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells. J Korean Med Sci 2007; 22: 898-904.
    • (2007) J Korean Med Sci , vol.22 , pp. 898-904
    • Kim, J.H.1    Jang, Y.S.2    Eom, K.S.3    Hwang, Y.I.4    Kang, H.R.5    Jang, S.H.6
  • 22
    • 79951797048 scopus 로고    scopus 로고
    • The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
    • Caja L, Bertran E, Campbell J, Fausto N, Fabregat I. The transforming growth factor-beta (TGF-beta) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol 2011; 226: 1214-1223.
    • (2011) J Cell Physiol , vol.226 , pp. 1214-1223
    • Caja, L.1    Bertran, E.2    Campbell, J.3    Fausto, N.4    Fabregat, I.5
  • 23
    • 33747362847 scopus 로고    scopus 로고
    • Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands
    • Del Castillo G, Murillo MM, Alvarez-Barrientos A, Bertran E, Fernandez M, et al. Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands. Exp Cell Res 2006; 312: 2860-2871.
    • (2006) Exp Cell Res , vol.312 , pp. 2860-2871
    • Del Castillo, G.1    Murillo, M.M.2    Alvarez-Barrientos, A.3    Bertran, E.4    Fernandez, M.5
  • 25
    • 20544462075 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis
    • Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 2005; 5: 1367-1374.
    • (2005) Am J Transplant , vol.5 , pp. 1367-1374
    • Vongwiwatana, A.1    Tasanarong, A.2    Rayner, D.C.3    Melk, A.4    Halloran, P.F.5
  • 26
    • 41549108935 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Aberrant recapitulation of developmental programs?
    • Selman M, Pardo A, Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 2008; 5: e62.
    • (2008) PLoS Med , vol.5
    • Selman, M.1    Pardo, A.2    Kaminski, N.3
  • 28
    • 52049087551 scopus 로고    scopus 로고
    • Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
    • Zeisberg M, Kalluri R. Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis. Front Biosci 2008; 13: 6991-6998.
    • (2008) Front Biosci , vol.13 , pp. 6991-6998
    • Zeisberg, M.1    Kalluri, R.2
  • 29
    • 36849021771 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    • Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007; 117: 3810-3820.
    • (2007) J Clin Invest , vol.117 , pp. 3810-3820
    • Higgins, D.F.1    Kimura, K.2    Bernhardt, W.M.3    Shrimanker, N.4    Akai, Y.5    Hohenstein, B.6
  • 31
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.